SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 4 HIS A 667
LEU A 442
LEU A 525
LEU A 530
None
0.99A 1a4lD-5f56A:
undetectable
1a4lD-5f56A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
3 / 4 VAL A 439
TRP A 465
TRP A 663
SO4  A 801 (-3.8A)
None
SO4  A 801 (-4.4A)
1.37A 1gmkA-5f56A:
undetectable
1gmkB-5f56A:
undetectable
1gmkA-5f56A:
2.35
1gmkB-5f56A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 LEU A 215
LEU A 218
GLY A 219
ALA A 193
LEU A 197
None
0.99A 1gs4A-5f56A:
undetectable
1gs4A-5f56A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 10 GLU A 208
GLU A 202
ALA A 199
LEU A  51
GLY A 191
None
1.32A 1mjqG-5f56A:
undetectable
1mjqH-5f56A:
undetectable
1mjqG-5f56A:
9.45
1mjqH-5f56A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
3 / 3 ASP A 158
HIS A 397
ASP A 223
None
None
MN  A 805 (-2.6A)
0.76A 1nw5A-5f56A:
3.5
1nw5A-5f56A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 10 HIS A 159
ALA A 401
VAL A 381
TYR A 114
PHE A 394
MN  A 805 (-3.4A)
None
None
None
None
1.20A 2d06B-5f56A:
undetectable
2d06B-5f56A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 6 LEU A 442
LEU A 512
PRO A  30
VAL A  31
None
1.17A 2dqyC-5f56A:
undetectable
2dqyC-5f56A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 6 ARG A  15
TRP A 665
PRO A  12
ALA A 683
None
1.45A 2ejfB-5f56A:
4.3
2ejfB-5f56A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 7 ARG A  15
TRP A 665
PRO A  12
ALA A 683
None
1.33A 2ejgA-5f56A:
3.1
2ejgA-5f56A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 8 ARG A 422
TYR A 363
THR A 375
ILE A 378
None
0.97A 2f9wA-5f56A:
2.2
2f9wB-5f56A:
undetectable
2f9wA-5f56A:
17.02
2f9wB-5f56A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 LEU A 215
LEU A 218
GLY A 219
ALA A 193
LEU A 197
None
1.06A 2oz7A-5f56A:
undetectable
2oz7A-5f56A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 11 LEU A 196
LEU A 197
LEU A 212
ILE A  64
VAL A 102
None
1.15A 2qd3A-5f56A:
4.6
2qd3A-5f56A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 11 ALA A 216
THR A 220
ARG A 184
GLU A  50
LEU A 187
None
1.30A 2v0mD-5f56A:
undetectable
2v0mD-5f56A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 10 GLY A 249
MET A 242
LEU A 291
LEU A 290
ILE A 275
None
1.17A 3kvrB-5f56A:
3.1
3kvrB-5f56A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 11 LEU A 291
ILE A 275
THR A 220
ALA A 190
ALA A  82
None
1.01A 3mdtB-5f56A:
undetectable
3mdtB-5f56A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 9 GLY A 249
MET A 242
LEU A 291
LEU A 290
ILE A 275
None
1.13A 3nbqA-5f56A:
3.3
3nbqA-5f56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 9 GLY A 249
MET A 242
LEU A 291
LEU A 290
ILE A 275
None
1.16A 3nbqD-5f56A:
3.5
3nbqD-5f56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 10 LEU A 464
VAL A 431
LEU A 530
PHE A 486
PHE A 488
None
1.18A 3tbgC-5f56A:
undetectable
3tbgC-5f56A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 4 ASP A  81
ASP A  83
GLY A  78
THR A  90
MN  A 804 (-1.9A)
MN  A 805 (-3.3A)
None
None
1.39A 3tl9B-5f56A:
undetectable
3tl9B-5f56A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 6 LEU A 212
LEU A 215
SER A  86
THR A  88
None
1.09A 4d7bB-5f56A:
undetectable
4d7bB-5f56A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
3 / 3 LEU A 250
MET A 254
ASP A 223
None
None
MN  A 805 (-2.6A)
0.79A 4j7xB-5f56A:
3.2
4j7xB-5f56A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
3 / 3 HIS A 124
GLY A 115
ILE A 116
None
0.63A 4k50A-5f56A:
undetectable
4k50A-5f56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 VAL A 681
ALA A 679
TYR A 682
VAL A 689
PHE A 624
None
1.16A 4mm4B-5f56A:
undetectable
4mm4B-5f56A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 10 TYR A  80
GLY A 395
SER A 404
GLY A 370
ASP A  79
None
None
None
None
MN  A 804 (-3.2A)
1.23A 4mmcA-5f56A:
undetectable
4mmcA-5f56A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 ASN A 460
LEU A  45
LEU A 450
LEU A 512
ALA A 510
None
1.17A 4rtbA-5f56A:
undetectable
4rtbA-5f56A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 LEU A 325
LEU A 337
ALA A 328
THR A 375
VAL A 350
None
1.14A 4x1yB-5f56A:
3.3
4x1yB-5f56A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
3 / 3 GLU A 143
LYS A 145
ASN A 140
None
1.07A 4y1dA-5f56A:
undetectable
4y1dD-5f56A:
undetectable
4y1dA-5f56A:
12.29
4y1dD-5f56A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 6 HIS A 108
GLY A 113
GLU A 112
ASN A 111
None
0.93A 4zbqA-5f56A:
undetectable
4zbqA-5f56A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 4 ALA A 400
PRO A 226
LEU A 187
HIS A 159
None
None
None
MN  A 805 (-3.4A)
1.49A 5eskA-5f56A:
0.8
5eskA-5f56A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 4 LEU A 634
LEU A 626
GLY A 601
GLU A 569
None
1.04A 5hhjA-5f56A:
undetectable
5hhjA-5f56A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 7 ARG A  15
GLU A 605
LEU A  18
LEU A  19
None
0.67A 5jq7A-5f56A:
undetectable
5jq7A-5f56A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 5 LEU A 685
PHE A 624
LEU A 612
TRP A 665
None
1.23A 5m10A-5f56A:
undetectable
5m10A-5f56A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 4 GLU A  50
THR A  52
THR A 220
LEU A 213
None
1.49A 5v96B-5f56A:
2.4
5v96B-5f56A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
5 / 12 LEU A  91
THR A 220
ALA A 199
LEU A 234
LEU A  57
None
1.23A 6ie8A-5f56A:
undetectable
6ie8A-5f56A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans)
4 / 8 ASP A 179
ARG A 184
GLU A  43
GLU A  50
None
1.06A 6mn4D-5f56A:
undetectable
6mn4D-5f56A:
18.31