SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.58A 1n6cA-5f59A:
13.5		 1n6cA-5f59A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.95A 2einN-5f59A:
undetectable
2einW-5f59A:
undetectable		 2einN-5f59A:
13.20
2einW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 10 GLY A4782
LEU A4783
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.3A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.33A 2h21A-5f59A:
7.2		 2h21A-5f59A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4782
LEU A4783
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.3A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.36A 2h21B-5f59A:
7.1		 2h21B-5f59A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4782
LEU A4783
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.3A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.39A 2h21C-5f59A:
7.9		 2h21C-5f59A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.33A 2r3aA-5f59A:
13.6		 2r3aA-5f59A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.80A 2r3aA-5f59A:
13.6		 2r3aA-5f59A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.97A 2zxwN-5f59A:
undetectable
2zxwW-5f59A:
undetectable		 2zxwN-5f59A:
13.20
2zxwW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 5 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.99A 3abkN-5f59A:
undetectable
3abkW-5f59A:
undetectable		 3abkN-5f59A:
13.20
3abkW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.93A 3ag1N-5f59A:
undetectable
3ag1W-5f59A:
undetectable		 3ag1N-5f59A:
13.20
3ag1W-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.00A 3ag2N-5f59A:
undetectable
3ag2W-5f59A:
undetectable		 3ag2N-5f59A:
13.20
3ag2W-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.95A 3ag4N-5f59A:
undetectable
3ag4W-5f59A:
undetectable		 3ag4N-5f59A:
13.20
3ag4W-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 8 MET A4765
LEU A4882
LEU A4785
ILE A4847
 None
 0.95A 3nbqB-5f59A:
undetectable		 3nbqB-5f59A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		7 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.50A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.44A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.41A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.70A 3opeA-5f59A:
16.1		 3opeA-5f59A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.42A 3rq4A-5f59A:
10.8		 3rq4A-5f59A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4823
HIS A4849
TYR A4886
PHE A4888
CYH A4899
 None
SAH  A5002 (-4.6A)
None
None
ZN  A5001 ( 2.0A)
 1.04A 3rq4A-5f59A:
10.8		 3rq4A-5f59A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.47A 3s8pA-5f59A:
10.6		 3s8pA-5f59A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.02A 3wg7A-5f59A:
undetectable
3wg7J-5f59A:
undetectable		 3wg7A-5f59A:
13.20
3wg7J-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.03A 3wg7N-5f59A:
undetectable
3wg7W-5f59A:
undetectable		 3wg7N-5f59A:
13.20
3wg7W-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.48A 4bupA-5f59A:
10.0		 4bupA-5f59A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.49A 4e47A-5f59A:
13.7		 4e47A-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.48A 4e47B-5f59A:
12.0		 4e47B-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.56A 4e47C-5f59A:
13.6		 4e47C-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.49A 4jdsA-5f59A:
10.8		 4jdsA-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.48A 4jdsB-5f59A:
13.8		 4jdsB-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.54A 4jdsC-5f59A:
13.7		 4jdsC-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.54A 4jlgA-5f59A:
13.6		 4jlgA-5f59A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 GLU A4858
PHE A4862
LYS A4758
TYR A4762
 None
 1.46A 4uciB-5f59A:
undetectable		 4uciB-5f59A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.30A 4ynmA-5f59A:
16.2		 4ynmA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.58A 4ynmB-5f59A:
17.3		 4ynmB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.50A 4ynpA-5f59A:
16.2		 4ynpA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.47A 4ynpA-5f59A:
16.2		 4ynpA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 10 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.21A 4ynpB-5f59A:
17.2		 4ynpB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 10 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.59A 4ynpB-5f59A:
17.2		 4ynpB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.66A 4ypaA-5f59A:
16.1		 4ypaA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.27A 4ypaB-5f59A:
16.4		 4ypaB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.32A 4ypaC-5f59A:
16.5		 4ypaC-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.51A 4ypaD-5f59A:
16.8		 4ypaD-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.76A 4ypeA-5f59A:
15.9		 4ypeA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.72A 4ypeB-5f59A:
16.6		 4ypeB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.49A 4ypeB-5f59A:
16.6		 4ypeB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.65A 4ypuA-5f59A:
16.0		 4ypuA-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.53A 4ypuB-5f59A:
17.1		 4ypuB-5f59A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 ILE A4780
GLY A4782
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-4.3A)
SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.54A 5ayfA-5f59A:
13.7		 5ayfA-5f59A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		3 / 3 GLY A4902
CYH A4906
CYH A4851
 None
ZN  A5001 (-2.4A)
ZN  A5001 (-2.1A)
 0.94A 5inzB-5f59A:
undetectable		 5inzB-5f59A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.96A 5iy5A-5f59A:
undetectable
5iy5J-5f59A:
undetectable		 5iy5A-5f59A:
13.20
5iy5J-5f59A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.65A 5jhnA-5f59A:
13.5		 5jhnA-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.68A 5jhnB-5f59A:
13.2		 5jhnB-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.74A 5jinA-5f59A:
13.5		 5jinA-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.72A 5jinB-5f59A:
13.2		 5jinB-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.70A 5jiyA-5f59A:
13.1		 5jiyA-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.73A 5jiyB-5f59A:
13.2		 5jiyB-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5jj0A-5f59A:
13.4		 5jj0A-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.31A 5jj0B-5f59A:
13.2		 5jj0B-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4846
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.9A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.38A 5kklB-5f59A:
5.9		 5kklB-5f59A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.65A 5lsuA-5f59A:
16.1		 5lsuA-5f59A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		3 / 3 ASN A4848
TYR A4886
CYH A4899
 SAH  A5002 (-2.7A)
None
ZN  A5001 ( 2.0A)
 0.19A 5lsuB-5f59A:
16.2		 5lsuB-5f59A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.64A 5t0kA-5f59A:
13.3		 5t0kA-5f59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.27A 5t0kB-5f59A:
13.4		 5t0kB-5f59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5t0mA-5f59A:
13.4		 5t0mA-5f59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5t0mB-5f59A:
13.2		 5t0mB-5f59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 10 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.78A 5tegB-5f59A:
15.9
5tegE-5f59A:
undetectable		 5tegB-5f59A:
29.52
5tegE-5f59A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 10 GLY A4782
TYR A4825
TYR A4846
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.9A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.63A 5tqrB-5f59A:
12.5		 5tqrB-5f59A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.69A 5ttfA-5f59A:
13.2		 5ttfA-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.27A 5ttfB-5f59A:
13.2		 5ttfB-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
ZN  A5001 ( 2.0A)
 0.74A 5ttfB-5f59A:
13.2		 5ttfB-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.36A 5ttfC-5f59A:
13.2		 5ttfC-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.77A 5ttfD-5f59A:
13.7		 5ttfD-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.39A 5ttfD-5f59A:
13.7		 5ttfD-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.73A 5ttgA-5f59A:
13.9		 5ttgA-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.42A 5ttgA-5f59A:
13.9		 5ttgA-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.76A 5ttgB-5f59A:
13.5		 5ttgB-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.42A 5ttgB-5f59A:
13.5		 5ttgB-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.66A 5tuyA-5f59A:
13.2		 5tuyA-5f59A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.69A 5tuyB-5f59A:
13.8		 5tuyB-5f59A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.34A 5tuzA-5f59A:
14.1		 5tuzA-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 None
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 1.04A 5tuzA-5f59A:
14.1		 5tuzA-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5tuzB-5f59A:
13.9		 5tuzB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.43A 5tuzB-5f59A:
13.9		 5tuzB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		7 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.66A 5updA-5f59A:
16.9		 5updA-5f59A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.61A 5v21A-5f59A:
15.7		 5v21A-5f59A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.72A 5v9iA-5f59A:
13.2		 5v9iA-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.25A 5v9iB-5f59A:
13.1		 5v9iB-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
ZN  A5001 ( 2.0A)
 0.77A 5v9iB-5f59A:
13.1		 5v9iB-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.76A 5v9iC-5f59A:
13.2		 5v9iC-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.42A 5v9iC-5f59A:
13.2		 5v9iC-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.86A 5v9iD-5f59A:
13.1		 5v9iD-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.37A 5v9iD-5f59A:
13.1		 5v9iD-5f59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.69A 5v9jA-5f59A:
14.1		 5v9jA-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.43A 5v9jA-5f59A:
14.1		 5v9jA-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.74A 5v9jB-5f59A:
13.5		 5v9jB-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.40A 5v9jB-5f59A:
13.5		 5v9jB-5f59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.69A 5vscA-5f59A:
13.2		 5vscA-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.24A 5vscB-5f59A:
13.5		 5vscB-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5vscB-5f59A:
13.5		 5vscB-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.33A 5vsdA-5f59A:
14.1		 5vsdA-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.74A 5vsdB-5f59A:
13.9		 5vsdB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.45A 5vsdB-5f59A:
13.9		 5vsdB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5vseA-5f59A:
13.3		 5vseA-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.26A 5vseB-5f59A:
13.1		 5vseB-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.72A 5vseB-5f59A:
13.1		 5vseB-5f59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.32A 5vsfA-5f59A:
14.0		 5vsfA-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5vsfB-5f59A:
14.0		 5vsfB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.46A 5vsfB-5f59A:
14.0		 5vsfB-5f59A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		3 / 3 TYR A4762
ARG A4763
THR A4767
 None
 0.70A 5z84J-5f59A:
undetectable		 5z84J-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.00A 5z86N-5f59A:
undetectable
5z86W-5f59A:
undetectable		 5z86N-5f59A:
13.20
5z86W-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.01A 5zcoN-5f59A:
undetectable
5zcoW-5f59A:
undetectable		 5zcoN-5f59A:
13.20
5zcoW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.32A 6a5kA-5f59A:
13.8		 6a5kA-5f59A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		7 / 12 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.45A 6a5mA-5f59A:
13.0		 6a5mA-5f59A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.09A 6a5mA-5f59A:
13.0		 6a5mA-5f59A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.45A 6a5mA-5f59A:
13.0		 6a5mA-5f59A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.46A 6agoA-5f59A:
15.8		 6agoA-5f59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		7 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.88A 6agoA-5f59A:
15.8		 6agoA-5f59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 11 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.43A 6agoA-5f59A:
15.8		 6agoA-5f59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.59A 6bp4B-5f59A:
13.3		 6bp4B-5f59A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		5 / 12 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.47A 6bp4B-5f59A:
13.3		 6bp4B-5f59A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		7 / 11 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.67A 6cenA-5f59A:
16.5		 6cenA-5f59A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		6 / 12 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.34A 6ineA-5f59A:
15.5		 6ineA-5f59A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 GLY A4782
LEU A4783
TYR A4825
ASN A4848
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.3A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
 0.69A 6nm4A-5f59A:
9.6		 6nm4A-5f59A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 6 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.88A 6nmfN-5f59A:
undetectable
6nmfW-5f59A:
undetectable		 6nmfN-5f59A:
13.20
6nmfW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C
(Homo
sapiens) 		4 / 7 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.96A 6nmpA-5f59A:
undetectable
6nmpJ-5f59A:
undetectable		 6nmpA-5f59A:
13.20
6nmpJ-5f59A:
14.38