SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5f5f ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 204
GLY A 196
PRO A 197
TYR A 276
PHE A 194
 None
G  H   2 ( 4.3A)
A  H  20 ( 4.6A)
None
None
 1.14A 1fdsA-5f5fA:
undetectable		 1fdsA-5f5fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5f5f ROQUIN-1
(Mus
musculus) 		4 / 6 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 0.98A 1mt1D-5f5fA:
undetectable
1mt1E-5f5fA:
undetectable		 1mt1D-5f5fA:
18.04
1mt1E-5f5fA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5f5f ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
 None
 1.29A 2bxfB-5f5fA:
undetectable		 2bxfB-5f5fA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 5f5f ROQUIN-1
(Mus
musculus) 		5 / 12 SER A 304
ASP A 310
HIS A 313
ASP A 284
TRP A 184
 None
 1.50A 4dfuA-5f5fA:
undetectable		 4dfuA-5f5fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 5f5f ROQUIN-1
(Mus
musculus) 		5 / 12 SER A 304
ASP A 310
HIS A 313
ASP A 284
TRP A 184
 None
 1.43A 4dfuB-5f5fA:
0.8		 4dfuB-5f5fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5f5f ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
 None
 1.17A 5dv4A-5f5fA:
undetectable		 5dv4A-5f5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5f5f ROQUIN-1
(Mus
musculus) 		4 / 6 TRP A 184
GLY A 295
ALA A 186
LEU A 183
 None
 0.93A 6fosA-5f5fA:
undetectable		 6fosA-5f5fA:
17.75