SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		5 / 10 GLY A  18
LEU A  59
GLN A  79
THR A  14
GLY A  15
 None
NAD  A 301 (-3.7A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 1.13A 1kvlA-5f5nA:
undetectable		 1kvlA-5f5nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 7 HIS A 275
LEU A 278
MET A 152
ILE A 182
 GOL  A 307 ( 4.6A)
None
None
None
 1.00A 1tuvA-5f5nA:
undetectable		 1tuvA-5f5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 6 SER A  77
ALA A 101
THR A 104
ALA A  68
 None
 0.81A 1w0gA-5f5nA:
undetectable		 1w0gA-5f5nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		5 / 10 ILE A 187
GLY A 188
GLY A  18
THR A  16
PRO A 148
 None
None
None
NAD  A 301 (-4.0A)
NAD  A 301 (-4.3A)
 1.12A 2y7wB-5f5nA:
undetectable		 2y7wB-5f5nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 5 GLN A 180
ALA A 209
ILE A 268
ARG A 272
 None
 1.39A 2z0aA-5f5nA:
undetectable		 2z0aA-5f5nA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		5 / 12 GLY A  12
GLY A  15
ASP A  58
LEU A  59
ASN A  60
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.3A)
NAD  A 301 (-3.2A)
NAD  A 301 (-3.7A)
NAD  A 301 ( 4.1A)
 1.23A 2zw9B-5f5nA:
3.1		 2zw9B-5f5nA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		5 / 12 GLY A  12
GLY A  15
GLY A  19
THR A  21
ASP A  58
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.3A)
None
None
NAD  A 301 (-3.2A)
 1.02A 3ihtA-5f5nA:
6.1		 3ihtA-5f5nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 7 LEU A 139
ASP A  99
ARG A  95
ALA A  98
 None
 1.25A 3mbgA-5f5nA:
undetectable
3mbgB-5f5nA:
undetectable		 3mbgA-5f5nA:
17.92
3mbgB-5f5nA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 8 PHE A 281
PHE A 155
PHE A 222
ALA A 219
 None
5VD  A 302 (-3.8A)
None
None
 1.04A 3t3sE-5f5nA:
undetectable		 3t3sE-5f5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		3 / 3 GLU A 133
TYR A 111
SER A 112
 None
 0.83A 4at0A-5f5nA:
3.5		 4at0A-5f5nA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		3 / 3 THR A  41
ASP A  42
ALA A  43
 None
 0.10A 5g5gB-5f5nA:
undetectable		 5g5gB-5f5nA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 5 SER A 113
VAL A 114
GLY A 116
ALA A 117
 None
NAD  A 301 ( 4.6A)
None
None
 0.96A 5k50A-5f5nA:
15.5		 5k50A-5f5nA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 5 LEU A  35
THR A  11
THR A  14
GLY A  12
 None
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.4A)
 1.21A 6gtqA-5f5nA:
undetectable		 6gtqA-5f5nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5f5n MONOOXYGENASE
(Micromonospora
sp.
TP-A0468) 		4 / 6 SER A  77
ALA A 101
THR A 104
ALA A  68
 None
 0.96A 6ma6A-5f5nA:
undetectable		 6ma6A-5f5nA:
14.00