SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		4 / 8 ASP A   8
ASP A  52
GLY A  60
ASP A 157
 None
 0.68A 1m4iA-5f64A:
undetectable		 1m4iA-5f64A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		4 / 7 LEU A 156
LEU A 194
PHE A  86
SER A 143
 None
 1.06A 1wrlE-5f64A:
undetectable
1wrlF-5f64A:
undetectable		 1wrlE-5f64A:
20.10
1wrlF-5f64A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 10 ILE A  75
ALA A   3
LEU A  20
ILE A  77
ILE A 110
 None
 1.20A 2w9sC-5f64A:
undetectable		 2w9sC-5f64A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 9 ILE A  13
ILE A   6
ILE A  50
MET A 106
ILE A   4
 None
 1.14A 3zosA-5f64A:
undetectable		 3zosA-5f64A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.46A 4r88A-5f64A:
2.6		 4r88A-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.44A 4r88B-5f64A:
2.6		 4r88B-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.46A 4r88C-5f64A:
2.6		 4r88C-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.46A 4r88D-5f64A:
undetectable		 4r88D-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.47A 4r88E-5f64A:
undetectable		 4r88E-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		5 / 12 LEU A 186
PHE A  86
ILE A 203
GLU A 148
SER A 145
 None
 1.45A 4r88F-5f64A:
2.6		 4r88F-5f64A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA
(Shigella
flexneri) 		4 / 7 ILE A 155
LEU A 156
ARG A 181
LEU A 186
 None
 0.97A 5xdqA-5f64A:
undetectable
5xdqJ-5f64A:
undetectable		 5xdqA-5f64A:
17.71
5xdqJ-5f64A:
13.59