SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3863
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.23A 1jtxA-5f6lA:
undetectable		 1jtxA-5f6lA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3887
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.23A 1jtxA-5f6lA:
undetectable		 1jtxA-5f6lA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.46A 1n6cA-5f6lA:
12.6		 1n6cA-5f6lA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		7 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.55A 2r3aA-5f6lA:
14.0		 2r3aA-5f6lA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		8 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.65A 3ooiA-5f6lA:
16.0		 3ooiA-5f6lA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.61A 3opeA-5f6lA:
16.1		 3opeA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.46A 3rq4A-5f6lA:
10.7		 3rq4A-5f6lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.51A 3s8pA-5f6lA:
9.3		 3s8pA-5f6lA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		4 / 8 VAL A3927
TYR A3942
CYH A3913
ILE A3856
 None
 1.16A 4bqtC-5f6lA:
undetectable
4bqtD-5f6lA:
undetectable		 4bqtC-5f6lA:
23.15
4bqtD-5f6lA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.53A 4bupA-5f6lA:
9.3		 4bupA-5f6lA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.40A 4e47A-5f6lA:
13.1		 4e47A-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.38A 4e47B-5f6lA:
11.3		 4e47B-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.45A 4e47C-5f6lA:
12.8		 4e47C-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.38A 4jdsA-5f6lA:
12.9		 4jdsA-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.39A 4jdsB-5f6lA:
12.9		 4jdsB-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.43A 4jdsC-5f6lA:
11.6		 4jdsC-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.43A 4jlgA-5f6lA:
12.7		 4jlgA-5f6lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 9 VAL A3831
ALA A3902
ARG A3841
ILE A3905
ILE A3928
 None
 1.35A 4oknB-5f6lA:
undetectable		 4oknB-5f6lA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.27A 4ynmA-5f6lA:
16.3		 4ynmA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.61A 4ynmB-5f6lA:
16.5		 4ynmB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.50A 4ynmB-5f6lA:
16.5		 4ynmB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.45A 4ynpA-5f6lA:
16.3		 4ynpA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 10 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.33A 4ynpB-5f6lA:
16.4		 4ynpB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 10 TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.62A 4ynpB-5f6lA:
16.4		 4ynpB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.58A 4ypaA-5f6lA:
16.3		 4ypaA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.23A 4ypaB-5f6lA:
16.4		 4ypaB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.26A 4ypaC-5f6lA:
15.8		 4ypaC-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.56A 4ypaD-5f6lA:
15.9		 4ypaD-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.63A 4ypeA-5f6lA:
16.3		 4ypeA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.56A 4ypeB-5f6lA:
16.9		 4ypeB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.43A 4ypeB-5f6lA:
16.9		 4ypeB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.61A 4ypuA-5f6lA:
16.0		 4ypuA-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.65A 4ypuB-5f6lA:
16.3		 4ypuB-5f6lA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.43A 5ayfA-5f6lA:
12.8		 5ayfA-5f6lA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 PHE A3904
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 1.44A 5cprB-5f6lA:
8.6		 5cprB-5f6lA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.82A 5jhnA-5f6lA:
13.2		 5jhnA-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.52A 5jhnA-5f6lA:
13.2		 5jhnA-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.78A 5jhnB-5f6lA:
13.2		 5jhnB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.53A 5jhnB-5f6lA:
13.2		 5jhnB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.49A 5jinA-5f6lA:
13.2		 5jinA-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.75A 5jinB-5f6lA:
13.3		 5jinB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.51A 5jinB-5f6lA:
13.3		 5jinB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.79A 5jiyA-5f6lA:
13.1		 5jiyA-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.51A 5jiyA-5f6lA:
13.1		 5jiyA-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.77A 5jiyB-5f6lA:
13.2		 5jiyB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.53A 5jiyB-5f6lA:
13.2		 5jiyB-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.49A 5jj0A-5f6lA:
13.1		 5jj0A-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.75A 5jj0B-5f6lA:
13.3		 5jj0B-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.26A 5jj0B-5f6lA:
13.3		 5jj0B-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
PHE A3946
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
None
 1.17A 5kklB-5f6lA:
6.9		 5kklB-5f6lA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
HIS A3907
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.46A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.65A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 HIS A3907
ASN A3969
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 1.48A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		3 / 3 ASN A3906
TYR A3944
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.26A 5lsuB-5f6lA:
16.0		 5lsuB-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.81A 5t0kA-5f6lA:
13.3		 5t0kA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.52A 5t0kA-5f6lA:
13.3		 5t0kA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.81A 5t0kB-5f6lA:
13.4		 5t0kB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.21A 5t0kB-5f6lA:
13.4		 5t0kB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.80A 5t0mA-5f6lA:
13.4		 5t0mA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.55A 5t0mA-5f6lA:
13.4		 5t0mA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.80A 5t0mB-5f6lA:
13.1		 5t0mB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.57A 5t0mB-5f6lA:
13.1		 5t0mB-5f6lA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 10 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.54A 5tegB-5f6lA:
17.0
5tegE-5f6lA:
undetectable		 5tegB-5f6lA:
35.33
5tegE-5f6lA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 10 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.65A 5tqrB-5f6lA:
11.9		 5tqrB-5f6lA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.85A 5ttfA-5f6lA:
13.1		 5ttfA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.52A 5ttfA-5f6lA:
13.1		 5ttfA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.42A 5ttfA-5f6lA:
13.1		 5ttfA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.84A 5ttfB-5f6lA:
13.0		 5ttfB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.50A 5ttfB-5f6lA:
13.0		 5ttfB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.38A 5ttfB-5f6lA:
13.0		 5ttfB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.89A 5ttfC-5f6lA:
12.9		 5ttfC-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.88A 5ttfD-5f6lA:
13.2		 5ttfD-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.59A 5ttfD-5f6lA:
13.2		 5ttfD-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.33A 5ttfD-5f6lA:
13.2		 5ttfD-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.52A 5ttgA-5f6lA:
13.4		 5ttgA-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.35A 5ttgA-5f6lA:
13.4		 5ttgA-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.91A 5ttgB-5f6lA:
13.2		 5ttgB-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.56A 5ttgB-5f6lA:
13.2		 5ttgB-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.35A 5ttgB-5f6lA:
13.2		 5ttgB-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.90A 5tuyA-5f6lA:
13.0		 5tuyA-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.46A 5tuyA-5f6lA:
13.0		 5tuyA-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.41A 5tuyA-5f6lA:
13.0		 5tuyA-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.83A 5tuyB-5f6lA:
13.4		 5tuyB-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.51A 5tuyB-5f6lA:
13.4		 5tuyB-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
CYH A3959
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.86A 5tuzA-5f6lA:
13.5		 5tuzA-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.28A 5tuzA-5f6lA:
13.5		 5tuzA-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 1.09A 5tuzA-5f6lA:
13.5		 5tuzA-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.89A 5tuzB-5f6lA:
13.4		 5tuzB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.51A 5tuzB-5f6lA:
13.4		 5tuzB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.36A 5tuzB-5f6lA:
13.4		 5tuzB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		8 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.61A 5updA-5f6lA:
15.9		 5updA-5f6lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		7 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
None
 0.62A 5v21A-5f6lA:
16.0		 5v21A-5f6lA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.93A 5v9iA-5f6lA:
12.9		 5v9iA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.50A 5v9iA-5f6lA:
12.9		 5v9iA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.47A 5v9iA-5f6lA:
12.9		 5v9iA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.86A 5v9iB-5f6lA:
13.0		 5v9iB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.52A 5v9iB-5f6lA:
13.0		 5v9iB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.40A 5v9iB-5f6lA:
13.0		 5v9iB-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.91A 5v9iC-5f6lA:
12.9		 5v9iC-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.53A 5v9iC-5f6lA:
12.9		 5v9iC-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.33A 5v9iC-5f6lA:
12.9		 5v9iC-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.62A 5v9iD-5f6lA:
12.9		 5v9iD-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.26A 5v9iD-5f6lA:
12.9		 5v9iD-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.54A 5v9jA-5f6lA:
13.6		 5v9jA-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.38A 5v9jA-5f6lA:
13.6		 5v9jA-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.57A 5v9jB-5f6lA:
13.3		 5v9jB-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.35A 5v9jB-5f6lA:
13.3		 5v9jB-5f6lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.87A 5vscA-5f6lA:
13.1		 5vscA-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.53A 5vscA-5f6lA:
13.1		 5vscA-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.88A 5vscB-5f6lA:
13.0		 5vscB-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.54A 5vscB-5f6lA:
13.0		 5vscB-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.24A 5vsdA-5f6lA:
13.5		 5vsdA-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.55A 5vsdB-5f6lA:
13.5		 5vsdB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.38A 5vsdB-5f6lA:
13.5		 5vsdB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.88A 5vseA-5f6lA:
13.2		 5vseA-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.54A 5vseA-5f6lA:
13.2		 5vseA-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.89A 5vseB-5f6lA:
12.9		 5vseB-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.56A 5vseB-5f6lA:
12.9		 5vseB-5f6lA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.25A 5vsfA-5f6lA:
13.5		 5vsfA-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.92A 5vsfB-5f6lA:
13.6		 5vsfB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.50A 5vsfB-5f6lA:
13.6		 5vsfB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 1.38A 5vsfB-5f6lA:
13.6		 5vsfB-5f6lA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		7 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.55A 6a5kA-5f6lA:
13.9		 6a5kA-5f6lA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 1.12A 6a5kA-5f6lA:
13.9		 6a5kA-5f6lA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		8 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.64A 6a5mA-5f6lA:
13.5		 6a5mA-5f6lA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 (-2.3A)
 1.25A 6a5mA-5f6lA:
13.5		 6a5mA-5f6lA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.81A 6agoA-5f6lA:
15.6		 6agoA-5f6lA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 GLY A3842
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 1.35A 6agoA-5f6lA:
15.6		 6agoA-5f6lA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 11 TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.73A 6agoA-5f6lA:
15.6		 6agoA-5f6lA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3840
HIS A3907
TYR A3944
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 (-2.3A)
None
 0.71A 6bp4A-5f6lA:
12.4		 6bp4A-5f6lA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		3 / 3 ILE A3838
ASN A3912
CYH A3845
 SAH  A4001 (-4.3A)
None
None
 0.91A 6bp4A-5f6lA:
12.3		 6bp4A-5f6lA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.71A 6bp4B-5f6lA:
12.7		 6bp4B-5f6lA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 (-2.3A)
 1.49A 6bp4B-5f6lA:
12.7		 6bp4B-5f6lA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 None
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.62A 6bp4B-5f6lA:
12.7		 6bp4B-5f6lA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		8 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.72A 6cenA-5f6lA:
16.1		 6cenA-5f6lA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3838
HIS A3839
PHE A3904
ASN A3906
HIS A3907
 SAH  A4001 (-4.3A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
 0.30A 6chgC-5f6lA:
17.1		 6chgC-5f6lA:
49.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3838
TYR A3883
PHE A3904
ASN A3906
HIS A3907
 SAH  A4001 (-4.3A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
 0.60A 6chgC-5f6lA:
17.1		 6chgC-5f6lA:
49.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		5 / 12 ILE A3838
TYR A3883
PHE A3904
ASN A3906
LEU A3955
 SAH  A4001 (-4.3A)
None
SAH  A4001 (-4.9A)
SAH  A4001 (-3.0A)
None
 1.29A 6chgC-5f6lA:
17.1		 6chgC-5f6lA:
49.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.24A 6ineA-5f6lA:
14.8		 6ineA-5f6lA:
22.93