SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.13A 1dz4A-5f7sA:
undetectable		 1dz4A-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.14A 1dz4B-5f7sA:
undetectable		 1dz4B-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PHE A 655
TYR A 656
VAL A 276
VAL A 175
 None
 1.32A 1dz6B-5f7sA:
undetectable		 1dz6B-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 SER A 300
SER A 333
PHE A 338
ALA A 331
 None
 1.24A 1fxvA-5f7sA:
undetectable
1fxvB-5f7sA:
undetectable		 1fxvA-5f7sA:
15.06
1fxvB-5f7sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PRO A 273
PHE A 655
GLU A 221
GLN A 217
 None
 1.40A 1l2iB-5f7sA:
undetectable		 1l2iB-5f7sA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 10 PHE A 655
TYR A 656
VAL A 276
VAL A 175
VAL A 218
 None
 1.44A 1o76A-5f7sA:
undetectable		 1o76A-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 PHE A 228
ARG A 247
ILE A 147
PHE A 146
ILE A 139
 None
 1.44A 1ot7A-5f7sA:
undetectable		 1ot7A-5f7sA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 LEU A 527
TYR A 557
GLY A 463
TYR A 510
LEU A 644
 None
 1.23A 1p91A-5f7sA:
undetectable		 1p91A-5f7sA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 9 PHE A 655
TYR A 656
VAL A 276
VAL A 175
VAL A 218
 None
 1.40A 1t86B-5f7sA:
undetectable		 1t86B-5f7sA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.09A 1t88B-5f7sA:
undetectable		 1t88B-5f7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 GLY A 468
GLY A 469
TYR A 496
GLU A 198
PHE A 431
 None
 1.16A 1w76A-5f7sA:
undetectable		 1w76A-5f7sA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 8 TYR A 656
VAL A 176
GLY A 177
ILE A 548
 None
 0.66A 2a1mB-5f7sA:
undetectable		 2a1mB-5f7sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 TYR A 479
GLY A 518
PHE A 519
SER A 522
 None
 0.96A 2a3cA-5f7sA:
2.9		 2a3cA-5f7sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 TYR A 479
GLY A 518
PHE A 519
SER A 522
 None
 0.94A 2a3cB-5f7sA:
3.0		 2a3cB-5f7sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 ARG A 484
ASP A 253
ASP A 193
 None
 0.72A 2ejtA-5f7sA:
undetectable		 2ejtA-5f7sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 8 ARG A  45
THR A 120
THR A  37
ILE A   2
 None
 0.88A 2f9wA-5f7sA:
undetectable
2f9wB-5f7sA:
undetectable		 2f9wA-5f7sA:
17.69
2f9wB-5f7sA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.07A 2feuA-5f7sA:
undetectable		 2feuA-5f7sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 8 ASP A 661
TRP A 665
TRP A 699
TYR A 693
 None
 1.33A 2ha2A-5f7sA:
undetectable		 2ha2A-5f7sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 8 ASP A 661
TRP A 665
TRP A 699
TYR A 693
 None
 1.35A 2ha2B-5f7sA:
undetectable		 2ha2B-5f7sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 TYR A 200
GLU A 330
HIS A 591
GLY A 301
 None
 1.15A 2ha4B-5f7sA:
undetectable		 2ha4B-5f7sA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 TRP A 607
PRO A 606
LEU A 562
GLY A 301
 None
 1.08A 2hs2B-5f7sA:
undetectable		 2hs2B-5f7sA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 HIS A 317
TRP A 304
ASN A 608
VAL A 609
ILE A 322
 None
 1.48A 2iyfA-5f7sA:
undetectable		 2iyfA-5f7sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.57A 2qmjA-5f7sA:
34.5		 2qmjA-5f7sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 VAL A 230
PHE A 146
ILE A 141
ASP A 140
PHE A 165
 None
 1.28A 2v95A-5f7sA:
undetectable		 2v95A-5f7sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 GLN A 199
ASP A 467
ASP A 532
PHE A 565
HIS A 591
 None
CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
 1.02A 2x2iA-5f7sA:
27.3		 2x2iA-5f7sA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 GLN A 199
ASP A 467
ASP A 532
PHE A 565
HIS A 591
 None
CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
 1.01A 2x2iC-5f7sA:
27.0		 2x2iC-5f7sA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 GLN A 199
ASP A 467
ASP A 532
PHE A 565
HIS A 591
 None
CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
 0.92A 2x2iD-5f7sA:
25.5		 2x2iD-5f7sA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 GLU A 221
ASP A 661
TYR A 693
 None
 0.78A 2yvlB-5f7sA:
undetectable		 2yvlB-5f7sA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.17A 2zawA-5f7sA:
undetectable		 2zawA-5f7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 TRP A 387
ARG A 516
TRP A 529
HIS A 591
 None
CA  A 805 ( 4.6A)
None
None
 1.45A 3deuA-5f7sA:
undetectable		 3deuA-5f7sA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 6 TYR A 500
GLY A 469
GLU A 470
GLU A 198
GLU A 180
 None
 1.35A 3fpjA-5f7sA:
undetectable		 3fpjA-5f7sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.09A 3fwgA-5f7sA:
undetectable		 3fwgA-5f7sA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 PRO A 135
PRO A 151
TYR A 238
ILE A 250
ILE A 141
 None
 1.37A 3ganA-5f7sA:
undetectable		 3ganA-5f7sA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 ARG A 247
THR A 236
THR A 268
 None
 0.42A 3k2hB-5f7sA:
undetectable		 3k2hB-5f7sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
None
CA  A 805 ( 4.6A)
None
None
 0.53A 3l4wA-5f7sA:
30.9		 3l4wA-5f7sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.56A 3phaA-5f7sA:
21.6		 3phaA-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.51A 3phaB-5f7sA:
24.0		 3phaB-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.52A 3phaC-5f7sA:
34.6		 3phaC-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.55A 3phaD-5f7sA:
34.6		 3phaD-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.54A 3pocA-5f7sA:
34.7		 3pocA-5f7sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.54A 3pocB-5f7sA:
36.1		 3pocB-5f7sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.67A 3topA-5f7sA:
31.1		 3topA-5f7sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.67A 3topB-5f7sA:
31.1		 3topB-5f7sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 THR A 274
PHE A 280
ASN A 278
ALA A 550
GLY A 551
 None
 1.02A 3v3oA-5f7sA:
undetectable		 3v3oA-5f7sA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.52A 3w37A-5f7sA:
35.5		 3w37A-5f7sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 ASP A 481
GLU A 487
GLY A 488
ASP A 438
 None
 0.92A 3w9tD-5f7sA:
undetectable		 3w9tD-5f7sA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.54A 3welA-5f7sA:
36.3		 3welA-5f7sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.56A 3wemA-5f7sA:
35.3		 3wemA-5f7sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.55A 3wenA-5f7sA:
35.2		 3wenA-5f7sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.52A 3weoA-5f7sA:
36.4		 3weoA-5f7sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.13A 3wrhE-5f7sA:
undetectable		 3wrhE-5f7sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.13A 3wrjE-5f7sA:
undetectable		 3wrjE-5f7sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 GLY A 279
ALA A 550
GLY A 551
GLU A 180
MET A 213
 None
 1.16A 4a6nA-5f7sA:
undetectable		 4a6nA-5f7sA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
GLU A 198
ARG A 516
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
None
CA  A 805 ( 4.6A)
None
None
 0.93A 4b9zA-5f7sA:
34.3		 4b9zA-5f7sA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 TYR A 200
ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 None
CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.67A 4b9zA-5f7sA:
34.3		 4b9zA-5f7sA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.12A 4ek1A-5f7sA:
undetectable		 4ek1A-5f7sA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 9 PHE A 655
TYR A 656
VAL A 276
VAL A 175
VAL A 218
 None
 1.37A 4ek1B-5f7sA:
undetectable		 4ek1B-5f7sA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 GLY A 468
GLY A 469
TYR A 496
GLU A 198
 None
 0.97A 4fgkB-5f7sA:
undetectable		 4fgkB-5f7sA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.10A 4g3rA-5f7sA:
undetectable		 4g3rA-5f7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.14A 4g3rB-5f7sA:
undetectable		 4g3rB-5f7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.08A 4l49A-5f7sA:
undetectable		 4l49A-5f7sA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.09A 4l4cA-5f7sA:
undetectable		 4l4cA-5f7sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 LEU A 678
VAL A 725
PRO A 724
TYR A 693
 None
 1.11A 4lb2A-5f7sA:
undetectable		 4lb2A-5f7sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 HIS A 317
TRP A 304
ASN A 608
VAL A 609
ILE A 322
 None
 1.48A 4m83A-5f7sA:
undetectable		 4m83A-5f7sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 GLN A 639
THR A 640
LEU A 556
THR A 549
 None
 0.84A 4mbsA-5f7sA:
undetectable		 4mbsA-5f7sA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 ASN A 305
GLU A 303
GLU A 330
GLU A 335
 None
 1.29A 4mi4A-5f7sA:
undetectable		 4mi4A-5f7sA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 ASN A 305
GLU A 303
GLU A 330
GLU A 335
 None
 1.26A 4mj8C-5f7sA:
undetectable		 4mj8C-5f7sA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.84A 4w5oA-5f7sA:
undetectable		 4w5oA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.83A 4z4cA-5f7sA:
undetectable		 4z4cA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.84A 4z4dA-5f7sA:
undetectable		 4z4dA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.85A 4z4eA-5f7sA:
undetectable		 4z4eA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 VAL A 682
ALA A 580
PHE A 540
 None
 0.87A 4z4iA-5f7sA:
undetectable		 4z4iA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 THR A 274
LEU A 277
THR A 646
LEU A 556
 None
 0.96A 4z91F-5f7sA:
1.5
4z91G-5f7sA:
1.4
4z91H-5f7sA:
1.4
4z91I-5f7sA:
1.5
4z91J-5f7sA:
1.5		 4z91F-5f7sA:
18.04
4z91G-5f7sA:
18.04
4z91H-5f7sA:
18.04
4z91I-5f7sA:
18.04
4z91J-5f7sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 8 SER A 522
TYR A 528
GLY A 518
GLY A 469
 None
 0.89A 5albL-5f7sA:
7.9		 5albL-5f7sA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 9 PHE A 655
TYR A 656
VAL A 276
VAL A 175
VAL A 218
 None
 1.41A 5cp4A-5f7sA:
undetectable		 5cp4A-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 VAL A 176
ASP A 186
ALA A 216
PHE A 228
ARG A 191
 None
 1.36A 5hnzB-5f7sA:
undetectable		 5hnzB-5f7sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 VAL A 682
ALA A 580
PHE A 540
 None
 0.85A 5js1A-5f7sA:
undetectable		 5js1A-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 5 GLU A 418
GLY A 474
ARG A   5
GLY A   8
 None
 1.06A 5kprA-5f7sA:
undetectable		 5kprA-5f7sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
None
CA  A 805 ( 4.6A)
None
None
 0.61A 5nn6A-5f7sA:
37.2		 5nn6A-5f7sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
CA  A 805 ( 4.6A)
None
None
 0.59A 5nn8A-5f7sA:
36.6		 5nn8A-5f7sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.81A 5t7bA-5f7sA:
undetectable		 5t7bA-5f7sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 7 GLY A 406
GLN A 388
TYR A 500
ASP A 395
 None
 1.17A 5vlmE-5f7sA:
undetectable		 5vlmE-5f7sA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 10 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.62A 5x7pA-5f7sA:
21.4		 5x7pA-5f7sA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 GLY A 521
ALA A 284
ALA A 524
ARG A 498
VAL A 494
 None
 1.16A 5yk2A-5f7sA:
undetectable		 5yk2A-5f7sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ARG A 452
GLY A 337
TYR A 346
TYR A 454
LEU A 455
 None
 1.48A 6a5mA-5f7sA:
undetectable		 6a5mA-5f7sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 GLN A 388
VAL A 328
VAL A 384
SER A 515
GLU A 470
 None
 1.35A 6bzoC-5f7sA:
undetectable		 6bzoC-5f7sA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
TRP A 529
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
None
 0.47A 6c9xA-5f7sA:
35.8		 6c9xA-5f7sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
TRP A 529
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
None
 0.46A 6c9xB-5f7sA:
36.0		 6c9xB-5f7sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.49A 6c9zA-5f7sA:
34.5		 6c9zA-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 12 ASP A 467
ARG A 516
TRP A 529
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
None
 0.49A 6c9zB-5f7sA:
35.9		 6c9zB-5f7sA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.49A 6ca1A-5f7sA:
34.7		 6ca1A-5f7sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.51A 6ca1B-5f7sA:
34.6		 6ca1B-5f7sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.53A 6ca3A-5f7sA:
35.9		 6ca3A-5f7sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		6 / 12 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.51A 6ca3B-5f7sA:
34.6		 6ca3B-5f7sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		5 / 11 ARG A 452
GLY A 337
TYR A 346
TYR A 454
LEU A 455
 None
 1.45A 6cenA-5f7sA:
undetectable		 6cenA-5f7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		3 / 3 ALA A  14
PHE A 197
GLN A 199
 None
 0.75A 6eceA-5f7sA:
undetectable		 6eceA-5f7sA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 ASP A 186
GLU A 221
ASP A 172
GLU A 170
 None
 1.47A 6mn5C-5f7sA:
undetectable		 6mn5C-5f7sA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5f7s GLYCOSIDE HYDROLASE
FAMILY 31
(Trueperella
pyogenes) 		4 / 6 ASP A 186
GLU A 221
ASP A 172
GLU A 170
 None
 1.42A 6mn5D-5f7sA:
undetectable		 6mn5D-5f7sA:
7.93