SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
5 / 11 THR L 162
VAL L 196
VAL L 145
GLU L 204
LYS L 205
None
1.48A 1t6zA-5f89L:
undetectable
1t6zA-5f89L:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
5f89 CAP248-2B HEAVY
CHAIN
CAP248-2B LIGHT
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 TYR L  36
PRO L  44
TYR L  87
TYR H  91
None
0.74A 2oldA-5f89L:
6.1
2oldB-5f89L:
24.8
2oldA-5f89L:
84.89
2oldB-5f89L:
84.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
3 / 3 THR L 115
SER L 138
PHE L 119
None
0.80A 3d4sA-5f89L:
undetectable
3d4sA-5f89L:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)
5f89 CAP248-2B HEAVY
CHAIN
CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
5 / 12 PHE H 166
VAL L 196
VAL L 145
PRO L 114
PHE L 140
None
1.44A 3nbrA-5f89H:
undetectable
3nbrA-5f89H:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
5 / 11 SER L 100
VAL L  97
LEU L   4
THR L   5
THR L  92
None
1.24A 4e0fA-5f89L:
undetectable
4e0fA-5f89L:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)
5f89 CAP248-2B HEAVY
CHAIN
CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
4 / 7 VAL H 169
SER L 180
GLN H 171
LEU H 141
None
1.08A 4hxyB-5f89H:
undetectable
4hxyB-5f89H:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvnH-5f89H:
undetectable
4qvnI-5f89H:
undetectable
4qvnH-5f89H:
18.60
4qvnI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 10 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvnV-5f89H:
undetectable
4qvnW-5f89H:
undetectable
4qvnV-5f89H:
18.60
4qvnW-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.82A 4qvpH-5f89H:
undetectable
4qvpI-5f89H:
undetectable
4qvpH-5f89H:
18.60
4qvpI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.82A 4qvpV-5f89H:
undetectable
4qvpW-5f89H:
undetectable
4qvpV-5f89H:
18.60
4qvpW-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvqH-5f89H:
undetectable
4qvqI-5f89H:
undetectable
4qvqH-5f89H:
18.60
4qvqI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.83A 4qvqV-5f89H:
undetectable
4qvqW-5f89H:
undetectable
4qvqV-5f89H:
18.60
4qvqW-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.85A 4qvvH-5f89H:
undetectable
4qvvH-5f89H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvvV-5f89H:
undetectable
4qvvV-5f89H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvyH-5f89H:
undetectable
4qvyH-5f89H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qvyV-5f89H:
undetectable
4qvyW-5f89H:
undetectable
4qvyV-5f89H:
18.60
4qvyW-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qw0H-5f89H:
undetectable
4qw0I-5f89H:
undetectable
4qw0H-5f89H:
18.60
4qw0I-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 4qw0V-5f89H:
undetectable
4qw0W-5f89H:
undetectable
4qw0V-5f89H:
18.60
4qw0W-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qw1H-5f89H:
undetectable
4qw1I-5f89H:
undetectable
4qw1H-5f89H:
18.60
4qw1I-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qw1V-5f89H:
undetectable
4qw1W-5f89H:
undetectable
4qw1V-5f89H:
18.60
4qw1W-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qwuH-5f89H:
undetectable
4qwuI-5f89H:
undetectable
4qwuH-5f89H:
18.60
4qwuI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qwuV-5f89H:
undetectable
4qwuW-5f89H:
undetectable
4qwuV-5f89H:
18.60
4qwuW-5f89H:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
5 / 7 TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
None
0.73A 5aclA-5f89L:
21.4
5aclA-5f89L:
71.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 5bxnH-5f89H:
undetectable
5bxnI-5f89H:
undetectable
5bxnH-5f89H:
20.37
5bxnI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 5cz7V-5f89H:
undetectable
5cz7W-5f89H:
undetectable
5cz7V-5f89H:
18.60
5cz7W-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.83A 5d0xV-5f89H:
undetectable
5d0xV-5f89H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
4 / 5 ALA L 174
TYR L 173
PRO L  40
GLY L  99
None
0.99A 5eslA-5f89L:
undetectable
5eslA-5f89L:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.81A 5l5fH-5f89H:
undetectable
5l5fI-5f89H:
undetectable
5l5fH-5f89H:
18.60
5l5fI-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.81A 5l5fV-5f89H:
undetectable
5l5fW-5f89H:
undetectable
5l5fV-5f89H:
18.60
5l5fW-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.85A 5l66H-5f89H:
undetectable
5l66I-5f89H:
undetectable
5l66H-5f89H:
18.60
5l66I-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.84A 5l66V-5f89H:
undetectable
5l66W-5f89H:
undetectable
5l66V-5f89H:
18.60
5l66W-5f89H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 MET H 108
SER H 177
LEU H 178
VAL H 150
HIS H 200
None
1.27A 5ubbA-5f89H:
undetectable
5ubbA-5f89H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)
5f89 CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
3 / 3 ARG L  54
ILE L  58
SER L  59
None
0.81A 5zw2A-5f89L:
undetectable
5zw2A-5f89L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5f89 CAP248-2B HEAVY
CHAIN
CAP248-2B LIGHT
CHAIN

(Homo
sapiens)
5 / 9 SER L 177
SER H 179
SER H 180
GLY H 139
THR L 115
None
1.39A 6awpA-5f89L:
undetectable
6awpA-5f89L:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
4 / 5 GLU H 148
PHE H 146
HIS H 200
THR H 110
None
1.20A 6b58A-5f89H:
undetectable
6b58A-5f89H:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.97A 6hwdH-5f89H:
undetectable
6hwdI-5f89H:
undetectable
6hwdH-5f89H:
19.31
6hwdI-5f89H:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)
5f89 CAP248-2B HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.97A 6hwdV-5f89H:
undetectable
6hwdV-5f89H:
19.31