SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
PHE A 198
ALA A 173
SER A 196
GLY A 194
 None
 1.08A 1igxA-5f8eA:
undetectable		 1igxA-5f8eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  51
VAL A  62
ALA A  25
MET A  69
GLY A  35
 None
 1.09A 1kiaA-5f8eA:
16.8		 1kiaA-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  74
VAL A  28
ALA A  52
MET A  40
GLY A  68
 None
 1.12A 1kiaA-5f8eA:
16.8		 1kiaA-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  51
VAL A  62
ALA A  25
MET A  69
GLY A  35
 None
 1.08A 1kiaB-5f8eA:
16.7		 1kiaB-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  74
VAL A  28
ALA A  52
MET A  40
GLY A  68
 None
 1.11A 1kiaB-5f8eA:
16.7		 1kiaB-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  51
VAL A  62
ALA A  25
MET A  69
GLY A  35
 None
 1.06A 1kiaC-5f8eA:
17.4		 1kiaC-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  74
VAL A  28
ALA A  52
MET A  40
GLY A  68
 None
 1.11A 1kiaC-5f8eA:
17.4		 1kiaC-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A  95
LEU A  37
VAL A  28
LEU A  27
 None
 0.89A 1mz9D-5f8eA:
undetectable		 1mz9D-5f8eA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  51
VAL A  62
ALA A  25
MET A  69
GLY A  35
 None
 1.07A 1nbhB-5f8eA:
17.6		 1nbhB-5f8eA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 200
SER A 182
SER A 204
ASP A 177
ILE A 201
 None
SAH  A 400 ( 4.7A)
None
SAH  A 400 ( 4.5A)
None
 1.21A 1nt2A-5f8eA:
13.8		 1nt2A-5f8eA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 217
ASP A 151
ASP A 156
GLU A 214
 None
 1.05A 1rjdA-5f8eA:
13.2		 1rjdA-5f8eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 217
ASP A 151
ASP A 156
GLU A 214
 None
 1.04A 1rjdB-5f8eA:
13.3		 1rjdB-5f8eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 143
GLY A 179
GLY A 181
SER A 204
LEU A 230
 SAH  A 400 ( 4.4A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
None
SAH  A 400 (-3.2A)
 1.06A 1rjdC-5f8eA:
13.4		 1rjdC-5f8eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 217
ASP A 151
ASP A 156
GLU A 214
 None
 1.03A 1rjdC-5f8eA:
13.4		 1rjdC-5f8eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 233
ALA A 176
ILE A 242
CYH A 180
GLY A 179
 None
None
None
None
SAH  A 400 (-4.0A)
 1.23A 2b17A-5f8eA:
undetectable		 2b17A-5f8eA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 111
LEU A  24
LEU A  94
LEU A  37
 None
 1.02A 2bfpA-5f8eA:
6.7		 2bfpA-5f8eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  84
GLY A  68
THR A  70
TYR A  77
 None
 0.96A 2g70A-5f8eA:
13.2		 2g70A-5f8eA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  84
GLY A  68
THR A  70
TYR A  77
 None
 0.95A 2g70B-5f8eA:
13.4		 2g70B-5f8eA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 311
ALA A 252
LEU A 314
PRO A 254
 None
 0.88A 3bgdA-5f8eA:
15.1		 3bgdA-5f8eA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 179
GLY A 181
PHE A 203
SER A 204
ASP A 229
 SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-3.6A)
None
SAH  A 400 (-4.1A)
 0.53A 3dlcA-5f8eA:
17.3		 3dlcA-5f8eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 179
ASP A 202
PHE A 203
ASP A 229
ASP A 246
 SAH  A 400 (-4.0A)
SAH  A 400 (-1.6A)
SAH  A 400 (-3.6A)
SAH  A 400 (-4.1A)
None
 0.77A 3iv6B-5f8eA:
14.5		 3iv6B-5f8eA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 179
PHE A 203
SER A 204
ASP A 229
ASP A 246
 SAH  A 400 (-4.0A)
SAH  A 400 (-3.6A)
None
SAH  A 400 (-4.1A)
None
 0.88A 3iv6D-5f8eA:
14.7		 3iv6D-5f8eA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 143
GLY A 179
GLY A 181
ASP A 229
LEU A 230
 SAH  A 400 ( 4.4A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-4.1A)
SAH  A 400 (-3.2A)
 0.95A 3o7wA-5f8eA:
11.4		 3o7wA-5f8eA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 143
GLY A 179
GLY A 181
PHE A 203
LEU A 230
 SAH  A 400 ( 4.4A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-3.6A)
SAH  A 400 (-3.2A)
 1.08A 3o7wA-5f8eA:
11.4		 3o7wA-5f8eA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 307
TYR A 132
GLY A 311
LEU A 314
ALA A 247
 None
None
None
None
SAH  A 400 ( 4.2A)
 1.27A 3ou7C-5f8eA:
15.0		 3ou7C-5f8eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 181
ASP A 202
ASP A 229
 SAH  A 400 (-3.4A)
SAH  A 400 (-1.6A)
SAH  A 400 (-4.1A)
 0.27A 3ou7C-5f8eA:
15.2		 3ou7C-5f8eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A 304
GLY A 129
PRO A 131
TYR A 135
 None
 1.25A 3u8qA-5f8eA:
undetectable		 3u8qA-5f8eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 12 SER A 146
ASP A 177
GLY A 179
ASP A 202
ASP A 229
ASP A 250
 SAH  A 400 (-3.0A)
SAH  A 400 ( 4.5A)
SAH  A 400 (-4.0A)
SAH  A 400 (-1.6A)
SAH  A 400 (-4.1A)
None
 0.73A 4pghB-5f8eA:
18.9		 4pghB-5f8eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 179
GLY A 181
SER A 182
ASP A 229
 SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 ( 4.7A)
SAH  A 400 (-4.1A)
 0.46A 5ergB-5f8eA:
11.7		 5ergB-5f8eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5f8e METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 11 SER A 146
GLY A 179
GLY A 181
ASP A 202
ASP A 229
ASP A 250
 SAH  A 400 (-3.0A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-1.6A)
SAH  A 400 (-4.1A)
None
 0.83A 6i5zD-5f8eA:
23.5		 6i5zD-5f8eA:
23.98