SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 11 LEU A 289
LEU A 310
HIS A  30
ALA A 286
GLY A 284
 None
 1.30A 1cmaA-5f8pA:
undetectable
1cmaB-5f8pA:
undetectable		 1cmaA-5f8pA:
12.17
1cmaB-5f8pA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 8 LEU A 109
PRO A  93
HIS A 231
VAL A 228
 FIJ  A 602 (-4.7A)
FIJ  A 602 (-4.5A)
FIJ  A 602 (-4.0A)
AKG  A 603 ( 4.7A)
 1.12A 1jtvA-5f8pA:
undetectable		 1jtvA-5f8pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 7 PHE A 139
ALA A  68
ILE A  97
ILE A 132
 None
 0.95A 1oniD-5f8pA:
undetectable
1oniF-5f8pA:
undetectable		 1oniD-5f8pA:
13.59
1oniF-5f8pA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 12 GLY A 498
VAL A 421
LEU A 439
LEU A 435
LEU A 418
 None
 1.03A 1ya4B-5f8pA:
undetectable		 1ya4B-5f8pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 12 GLY A 498
VAL A 421
LEU A 439
LEU A 435
LEU A 418
 None
 0.99A 1ya4C-5f8pA:
undetectable		 1ya4C-5f8pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		3 / 3 ALA A  68
THR A 138
PHE A 317
 None
 0.73A 2c6nB-5f8pA:
undetectable		 2c6nB-5f8pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		3 / 3 TRP A 395
LYS A 128
PRO A 117
 None
 1.39A 2dqyB-5f8pA:
undetectable		 2dqyB-5f8pA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 12 LEU A 439
ILE A 434
THR A 414
VAL A 417
VAL A 493
 None
 1.08A 2g78A-5f8pA:
undetectable		 2g78A-5f8pA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		3 / 3 THR A 202
SER A 319
PHE A 296
 None
 0.85A 3d4sA-5f8pA:
undetectable		 3d4sA-5f8pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		3 / 3 LYS A 107
ARG A 112
TRP A 378
 None
SO4  A 601 (-2.8A)
None
 1.16A 4i90A-5f8pA:
undetectable		 4i90A-5f8pA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 9 LEU A 356
GLY A 367
VAL A 413
VAL A 417
LEU A 418
 None
 1.17A 4qd3A-5f8pA:
undetectable		 4qd3A-5f8pA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		6 / 8 LEU A  90
THR A  92
PRO A  93
ARG A  96
LEU A 109
HIS A 231
 FIJ  A 602 (-3.9A)
FIJ  A 602 (-3.7A)
FIJ  A 602 (-4.5A)
AKG  A 603 (-3.4A)
FIJ  A 602 (-4.7A)
FIJ  A 602 (-4.0A)
 0.72A 4qknA-5f8pA:
56.8		 4qknA-5f8pA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		7 / 8 LEU A  90
THR A  92
PRO A  93
LEU A 109
VAL A 228
SER A 229
HIS A 231
 FIJ  A 602 (-3.9A)
FIJ  A 602 (-3.7A)
FIJ  A 602 (-4.5A)
FIJ  A 602 (-4.7A)
AKG  A 603 ( 4.7A)
FIJ  A 602 (-2.9A)
FIJ  A 602 (-4.0A)
 0.71A 4qknA-5f8pA:
56.8		 4qknA-5f8pA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 9 TYR A 106
THR A 111
LEU A 203
THR A  92
VAL A  83
 None
None
None
FIJ  A 602 (-3.7A)
None
 1.40A 5cp4A-5f8pA:
undetectable		 5cp4A-5f8pA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 4 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.39A 5n0rA-5f8pA:
undetectable		 5n0rA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 4 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.38A 5n0sA-5f8pA:
undetectable		 5n0sA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 5 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.40A 5n0tA-5f8pA:
undetectable		 5n0tA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 4 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.35A 5n0wA-5f8pA:
undetectable		 5n0wA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 5 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.34A 5n0wB-5f8pA:
undetectable		 5n0wB-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 4 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.37A 5n0xA-5f8pA:
undetectable		 5n0xA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		4 / 5 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.35A 5n4iA-5f8pA:
undetectable		 5n4iA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		3 / 3 ARG A 380
ARG A 455
ARG A 112
 None
None
SO4  A 601 (-2.8A)
 0.97A 5vcgA-5f8pA:
undetectable		 5vcgA-5f8pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens) 		5 / 12 TYR A 295
LEU A 289
PHE A  69
HIS A 321
VAL A  65
 AKG  A 603 (-4.6A)
None
None
None
None
 1.36A 6djzB-5f8pA:
4.4		 6djzB-5f8pA:
17.63