SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 9 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.51A 1bcuH-5f8zA:
35.6
1bcuH-5f8zA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
None
0.45A 1dwcH-5f8zA:
34.7
1dwcH-5f8zA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.47A 1etrH-5f8zA:
34.7
1etrH-5f8zA:
39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 ILE A  16
ILE A 176
LEU A 199
VAL A 138
ILE A 160
None
1.07A 1oipA-5f8zA:
undetectable
1oipA-5f8zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 5 VAL A 138
THR A 139
GLN A  30
ILE A 121
None
1.37A 1ss4A-5f8zA:
undetectable
1ss4A-5f8zA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.41A 1tnlA-5f8zA:
34.3
1tnlA-5f8zA:
41.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 11 GLY A 197
LEU A  33
HIS A  40
ILE A  16
ALA A 190
None
1.38A 2a58A-5f8zA:
undetectable
2a58E-5f8zA:
undetectable
2a58A-5f8zA:
24.05
2a58E-5f8zA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 11 ILE A  16
ALA A 190
GLY A 197
LEU A  33
HIS A  40
None
1.38A 2a58C-5f8zA:
undetectable
2a58D-5f8zA:
undetectable
2a58C-5f8zA:
24.05
2a58D-5f8zA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
1.00A 2f80A-5f8zA:
undetectable
2f80A-5f8zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
0.89A 2hs2A-5f8zA:
undetectable
2hs2A-5f8zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
1.02A 2hs2B-5f8zA:
undetectable
2hs2B-5f8zA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.53A 2otvA-5f8zA:
34.5
2otvA-5f8zA:
41.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
None
1.39A 2oxtD-5f8zA:
undetectable
2oxtD-5f8zA:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 12 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 226
TYR A 228
None
0.56A 2p16A-5f8zA:
35.6
2p16A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 12 ASP A 189
ALA A 190
TRP A 215
GLY A 216
GLY A 226
TYR A 228
None
0.27A 2p16A-5f8zA:
35.6
2p16A-5f8zA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
3 / 3 ARG A 208
SER A 125
TYR A 133
None
0.97A 2q2hA-5f8zA:
undetectable
2q2hB-5f8zA:
undetectable
2q2hA-5f8zA:
17.95
2q2hB-5f8zA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
7 / 12 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 219
GLY A 226
TYR A 228
None
0.50A 2w26A-5f8zA:
35.3
2w26A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
7 / 12 ASP A 189
ALA A 190
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
None
0.34A 2w26A-5f8zA:
35.3
2w26A-5f8zA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
1.00A 3d1zA-5f8zA:
undetectable
3d1zA-5f8zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
1.07A 3d20A-5f8zA:
undetectable
3d20A-5f8zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 7 TRP A 141
LEU A  71
SER A  22
THR A 139
None
SO4  A 302 (-3.0A)
None
None
1.32A 3dzgB-5f8zA:
undetectable
3dzgB-5f8zA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.42A 3gy3A-5f8zA:
17.2
3gy3A-5f8zA:
41.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.90A 3keeA-5f8zA:
10.9
3keeA-5f8zA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.88A 3keeC-5f8zA:
10.6
3keeC-5f8zA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.71A 3keeD-5f8zA:
11.0
3keeD-5f8zA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 10 GLY A 226
ALA A 183
GLY A 211
VAL A 158
ILE A 160
None
1.10A 3nu6B-5f8zA:
undetectable
3nu6B-5f8zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
None
1.03A 3nvkI-5f8zA:
undetectable
3nvkI-5f8zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 6 TRP A 141
LEU A  71
SER A  22
THR A 139
None
SO4  A 302 (-3.0A)
None
None
1.31A 3ropA-5f8zA:
undetectable
3ropA-5f8zA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.45A 3rxfA-5f8zA:
17.3
3rxfA-5f8zA:
41.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.76A 3sueA-5f8zA:
10.1
3sueA-5f8zA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.74A 3sufA-5f8zA:
10.3
3sufA-5f8zA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
3 / 3 TRP A 137
TRP A  27
THR A 139
SO4  A 304 (-4.0A)
SO4  A 304 ( 4.7A)
None
1.41A 4bboB-5f8zA:
undetectable
4bboB-5f8zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
None
1.02A 4fakA-5f8zA:
undetectable
4fakA-5f8zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
None
0.93A 4fakA-5f8zA:
undetectable
4fakA-5f8zA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 HIS A  57
ASP A 189
ALA A 190
TRP A 215
GLY A 226
None
0.22A 4hfpD-5f8zA:
34.6
4hfpD-5f8zA:
39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
3 / 3 ASP A 102
TRP A  65
SER A 195
None
0.94A 4lrhB-5f8zA:
undetectable
4lrhB-5f8zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
3 / 3 ASP A 102
TRP A  65
SER A 195
None
1.01A 4lrhF-5f8zA:
undetectable
4lrhF-5f8zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 ILE A  47
GLN A  30
THR A 139
LEU A 209
TRP A 208
None
1.43A 4qynB-5f8zA:
undetectable
4qynB-5f8zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
4 / 6 LEU A 155
ILE A 154
LYS A 157
GLU A  26
SO4  A 302 (-4.7A)
None
SO4  A 304 (-3.7A)
SO4  A 304 (-3.6A)
0.64A 4w5nA-5f8zA:
undetectable
4w5nA-5f8zA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 5eiwC-5f8zA:
undetectable
5eiwC-5f8zA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 211
SER A  45
THR A 229
VAL A 181
VAL A 200
None
1.06A 5kocB-5f8zA:
undetectable
5kocB-5f8zA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY A 211
THR A 229
VAL A 181
VAL A 200
LEU A 199
None
1.08A 5kocB-5f8zA:
undetectable
5kocB-5f8zA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 10 LEU A 155
GLY A  44
GLY A 197
ILE A  70
LEU A  33
SO4  A 302 (-4.7A)
None
None
None
None
1.00A 5l0zB-5f8zA:
undetectable
5l0zB-5f8zA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo
sapiens)
5 / 9 VAL A 210
GLY A 184
TYR A 228
VAL A 163
PRO A 225
None
1.35A 5zniA-5f8zA:
undetectable
5zniA-5f8zA:
16.95