SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
CH235.9 HEAVY CHAIN
(Human
immunodeficiency
virus
1;
Homo
sapiens) 		4 / 5 THR G 430
LEU G 122
GLY G 124
LYS H  74
 None
 1.23A 1gtiF-5f9oG:
undetectable		 1gtiF-5f9oG:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		4 / 7 PHE G 210
VAL G 108
TRP G 112
TRP G 427
 None
 1.48A 1jqdA-5f9oG:
undetectable		 1jqdA-5f9oG:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		4 / 7 LEU G 259
LEU G 453
ILE G 272
SER G 274
 None
 1.21A 2hc4A-5f9oG:
undetectable		 2hc4A-5f9oG:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
CH235.9 HEAVY CHAIN
(Human
immunodeficiency
virus
1;
Homo
sapiens) 		4 / 4 ASP H  52
ASP G 368
ASP H  31
GLY G 473
 None
 1.47A 2igtC-5f9oH:
undetectable		 2igtC-5f9oH:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ASP H  52
ILE H  51
LEU H  79
TYR H  27
 None
 1.07A 2ya7B-5f9oH:
undetectable		 2ya7B-5f9oH:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		4 / 6 ASP G 440
ILE G 326
GLN G 422
GLU G 381
 None
None
EPE  G 514 ( 4.6A)
None
 1.40A 2ya7C-5f9oG:
undetectable		 2ya7C-5f9oG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ASP H  52
ILE H  51
LEU H  79
TYR H  27
 None
 1.07A 2ya7D-5f9oH:
undetectable		 2ya7D-5f9oH:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 119
GLU H 157
HIS H 209
 None
 0.83A 3g1uB-5f9oH:
undetectable		 3g1uB-5f9oH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.53A 3huoA-5f9oH:
undetectable		 3huoA-5f9oH:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		4 / 8 ASN G 392
TRP G 338
ASN G 334
THR G 413
 NAG  G 511 (-1.9A)
None
NAG  G 508 (-1.8A)
None
 1.25A 4d1yA-5f9oG:
undetectable
4d1yB-5f9oG:
undetectable		 4d1yA-5f9oG:
19.43
4d1yB-5f9oG:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG H  98
HIS H 111
TYR H  32
 None
 1.24A 4fu9A-5f9oH:
undetectable		 4fu9A-5f9oH:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		3 / 3 ARG G 327
LYS G 328
LYS G 325
 EPE  G 514 ( 4.0A)
None
None
 1.30A 4k50A-5f9oG:
undetectable		 4k50A-5f9oG:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		3 / 3 ARG G 327
LYS G 328
LYS G 325
 EPE  G 514 ( 4.0A)
None
None
 1.36A 4k50E-5f9oG:
undetectable		 4k50E-5f9oG:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		3 / 3 ARG G 327
LYS G 328
LYS G 325
 EPE  G 514 ( 4.0A)
None
None
 1.36A 4k50I-5f9oG:
undetectable		 4k50I-5f9oG:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 ALA H 146
THR H 192
GLY H 143
GLY H 142
SER H 141
 None
 1.06A 4qvwK-5f9oH:
undetectable
4qvwL-5f9oH:
undetectable		 4qvwK-5f9oH:
23.39
4qvwL-5f9oH:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 ALA H 146
THR H 192
GLY H 143
GLY H 142
SER H 141
 None
 1.06A 4qvwY-5f9oH:
undetectable
4qvwZ-5f9oH:
undetectable		 4qvwY-5f9oH:
23.39
4qvwZ-5f9oH:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU H 107
LEU H 106
TRP H  50
 None
 0.89A 5nwuA-5f9oH:
undetectable		 5nwuA-5f9oH:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
(Human
immunodeficiency
virus
1) 		4 / 6 HIS G 374
ASN G 377
VAL G 255
LEU G 260
 None
 1.28A 5xdhA-5f9oG:
undetectable
5xdhC-5f9oG:
undetectable		 5xdhA-5f9oG:
10.34
5xdhC-5f9oG:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		5 / 9 VAL H  68
GLY H   8
TYR H  94
MET H  81
GLY H  10
 None
 1.20A 5zniA-5f9oH:
undetectable		 5zniA-5f9oH:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO H 194
SER H 196
SER H 197
 None
 0.66A 6bpyA-5f9oH:
undetectable		 6bpyA-5f9oH:
19.69