SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  76
ILE A 220
LEU A 272
GLY A 206
ALA A  85
 None
 1.31A 1e7aA-5f9sA:
undetectable		 1e7aA-5f9sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		6 / 11 PHE A 310
LEU A 384
ALA A 383
ALA A 379
THR A 323
LEU A 302
 None
 1.26A 1jinA-5f9sA:
undetectable		 1jinA-5f9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 153
PHE A 152
LEU A 181
GLU A 157
TYR A 204
 None
 1.37A 1kw0A-5f9sA:
undetectable		 1kw0A-5f9sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 4 LEU A 219
PRO A  34
ILE A 279
LEU A 276
 None
 1.14A 1ya4C-5f9sA:
undetectable		 1ya4C-5f9sA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 GLY A 189
ILE A 279
SER A 287
GLN A 290
 None
 0.96A 2a8tB-5f9sA:
undetectable		 2a8tB-5f9sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 5 ARG A 301
THR A 377
LEU A 307
ALA A 304
 None
 1.43A 2e1qD-5f9sA:
undetectable		 2e1qD-5f9sA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A  60
GLY A 206
VAL A 185
SER A  31
PRO A 215
 None
None
PLP  A 401 (-4.0A)
None
None
 1.11A 2okcA-5f9sA:
3.4		 2okcA-5f9sA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 5 SER A 159
GLY A 106
ASP A 167
ASP A 183
 None
None
None
PLP  A 401 (-2.7A)
 1.13A 2oxtB-5f9sA:
undetectable		 2oxtB-5f9sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 220
SER A 207
GLY A  82
LEU A 242
ASN A  92
 None
None
PLP  A 401 (-3.6A)
None
None
 1.26A 2zw9A-5f9sA:
undetectable		 2zw9A-5f9sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 7 LYS A  61
ILE A  64
GLN A  65
LEU A 284
 None
 0.88A 3bjwB-5f9sA:
undetectable		 3bjwB-5f9sA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 GLN A  65
SER A 218
LEU A 242
SER A 221
ALA A  88
 None
 1.25A 3d91A-5f9sA:
undetectable		 3d91A-5f9sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 GLU A  87
TYR A 241
SER A 218
ILE A 220
 None
 1.04A 3jz0B-5f9sA:
undetectable		 3jz0B-5f9sA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 GLY A 103
GLY A 106
VAL A 162
GLU A 157
 None
 0.56A 4fgzB-5f9sA:
3.3		 4fgzB-5f9sA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 360
GLY A 161
ASN A 105
GLU A 157
 None
 1.25A 4g0vB-5f9sA:
undetectable		 4g0vB-5f9sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 154
GLY A 109
VAL A 113
TYR A 204
 PLP  A 401 ( 4.4A)
None
None
None
 1.16A 4grkA-5f9sA:
undetectable		 4grkA-5f9sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 381
GLU A 378
PHE A 343
 None
 0.86A 4kszA-5f9sA:
undetectable		 4kszA-5f9sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 ASN A  72
MET A 230
LEU A 179
ILE A 220
 None
 0.96A 4ok1A-5f9sA:
undetectable		 4ok1A-5f9sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 5 SER A 187
ALA A 186
HIS A 155
LEU A 163
 None
PLP  A 401 (-3.0A)
None
None
 1.48A 5dzkb-5f9sA:
undetectable
5dzkp-5f9sA:
undetectable		 5dzkb-5f9sA:
20.87
5dzkp-5f9sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 PRO A 353
GLY A 106
THR A 127
GLU A 157
SER A 158
 None
None
None
None
PLP  A 401 (-1.8A)
 1.13A 5hfjE-5f9sA:
undetectable		 5hfjE-5f9sA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A 356
THR A 355
SER A 354
GLY A 352
 None
 0.76A 5k4pA-5f9sA:
2.3		 5k4pA-5f9sA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 182
ASP A 183
LEU A 284
GLY A 206
LEU A 219
 None
PLP  A 401 (-2.7A)
None
None
None
 1.17A 5ogcB-5f9sA:
3.0		 5ogcB-5f9sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 360
GLY A  27
SER A 158
THR A 320
 None
None
PLP  A 401 (-1.8A)
None
 1.18A 5ysiA-5f9sA:
undetectable		 5ysiA-5f9sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 6 SER A 218
GLU A  87
ARG A 118
ASP A 114
 None
 1.26A 5zw4A-5f9sA:
undetectable		 5zw4A-5f9sA:
18.78