SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 6 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.07A 1mt1A-5f9wB:
undetectable
1mt1F-5f9wB:
undetectable		 1mt1A-5f9wB:
10.67
1mt1F-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 6 ILE B  67
ARG B  66
ASP B  86
LEU B  82
 None
 1.05A 1mt1B-5f9wB:
undetectable
1mt1C-5f9wB:
undetectable		 1mt1B-5f9wB:
17.59
1mt1C-5f9wB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		5 / 12 LEU B   4
CYH B  92
VAL B  37
LEU B  47
HIS B  35
 None
 1.13A 2jn3A-5f9wB:
undetectable		 2jn3A-5f9wB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 7 ILE B  67
ARG B  66
ASP B  86
LEU B  82
 None
 1.08A 2qqcB-5f9wB:
undetectable
2qqcC-5f9wB:
undetectable		 2qqcB-5f9wB:
17.59
2qqcC-5f9wB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 7 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.05A 2qqcA-5f9wB:
undetectable
2qqcF-5f9wB:
undetectable		 2qqcA-5f9wB:
10.67
2qqcF-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 7 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.04A 2qqcG-5f9wB:
undetectable
2qqcJ-5f9wB:
undetectable		 2qqcG-5f9wB:
10.67
2qqcJ-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 7 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.04A 2qqcI-5f9wB:
undetectable
2qqcL-5f9wB:
undetectable		 2qqcI-5f9wB:
10.67
2qqcL-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 7 TRP B  50
HIS B  35
ASN B  95
TYR B  33
 None
 1.47A 4a3uB-5f9wB:
undetectable		 4a3uB-5f9wB:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 5 VAL B   2
TYR B  27
ARG B  94
TYR B 102
 None
 0.43A 4m7kH-5f9wB:
23.0		 4m7kH-5f9wB:
76.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		5 / 11 ALA B 137
THR B 183
GLY B 134
GLY B 133
SER B 132
 None
 1.07A 4qvwK-5f9wB:
undetectable
4qvwL-5f9wB:
undetectable		 4qvwK-5f9wB:
23.01
4qvwL-5f9wB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		5 / 11 ALA B 137
THR B 183
GLY B 134
GLY B 133
SER B 132
 None
 1.07A 4qvwY-5f9wB:
undetectable
4qvwZ-5f9wB:
undetectable		 4qvwY-5f9wB:
23.01
4qvwZ-5f9wB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		3 / 3 SER B  21
LEU B  82
MET B  82
 None
 0.83A 5ikrB-5f9wB:
undetectable		 5ikrB-5f9wB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		3 / 3 LEU B 100
LEU B 100
TRP B  50
 None
 0.76A 5nwuA-5f9wB:
undetectable		 5nwuA-5f9wB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens) 		4 / 5 GLU B 148
PHE B 146
HIS B 200
THR B 110
 None
 1.09A 6b58A-5f9wB:
undetectable		 6b58A-5f9wB:
17.77