SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		3 / 3 TRP A  96
VAL A 114
TRP A 179
 PLP  A 401 (-3.4A)
None
KCX  A 141 (-3.6A)
 0.82A 1c4dA-5facA:
undetectable
1c4dB-5facA:
undetectable		 1c4dA-5facA:
7.04
1c4dB-5facA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 HIS A  52
GLY A  51
ALA A  49
TYR A  50
 None
None
None
PLP  A 401 (-4.6A)
 0.91A 1dmaA-5facA:
undetectable		 1dmaA-5facA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 9 VAL A 272
VAL A 318
LEU A 338
ALA A 347
LEU A 269
 None
 1.18A 1eqgA-5facA:
undetectable		 1eqgA-5facA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 10 ARG A 328
SER A 311
ALA A 310
GLY A 305
ALA A 369
 None
 1.08A 1gtnB-5facA:
undetectable
1gtnC-5facA:
undetectable		 1gtnB-5facA:
10.98
1gtnC-5facA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 10 ARG A 328
SER A 311
ALA A 310
GLY A 305
ALA A 369
 None
 1.05A 1gtnH-5facA:
undetectable
1gtnI-5facA:
undetectable		 1gtnH-5facA:
10.98
1gtnI-5facA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 10 THR A 289
PRO A 290
GLY A 291
THR A 294
GLY A 339
 None
 1.17A 1h4oA-5facA:
undetectable
1h4oB-5facA:
undetectable		 1h4oA-5facA:
17.19
1h4oB-5facA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 9 THR A 289
PRO A 290
GLY A 291
THR A 294
GLY A 339
 None
 1.33A 1h4oE-5facA:
undetectable
1h4oF-5facA:
undetectable		 1h4oE-5facA:
17.19
1h4oF-5facA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 8 LYS A  46
TYR A  50
ARG A 148
TYR A 374
 PLP  A 401 (-1.3A)
PLP  A 401 (-4.6A)
KCX  A 141 ( 4.2A)
PLP  A 401 (-4.2A)
 0.93A 1xqlA-5facA:
43.2
1xqlB-5facA:
43.1		 1xqlA-5facA:
35.58
1xqlB-5facA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 8 LYS A  46
TYR A  50
ARG A 148
TYR A 374
 PLP  A 401 (-1.3A)
PLP  A 401 (-4.6A)
KCX  A 141 ( 4.2A)
PLP  A 401 (-4.2A)
 0.97A 1xqlA-5facA:
43.2
1xqlB-5facA:
43.1		 1xqlA-5facA:
35.58
1xqlB-5facA:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		3 / 3 THR A 225
PRO A 223
THR A 227
 None
 0.71A 209dC-5facA:
undetectable		 209dC-5facA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 10 THR A 289
PRO A 290
GLY A 291
THR A 294
GLY A 339
 None
 1.33A 2vl2A-5facA:
undetectable
2vl2C-5facA:
undetectable		 2vl2A-5facA:
19.13
2vl2C-5facA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 ASN A  28
ALA A  61
ALA A  60
ALA A  64
 None
 0.84A 3a2qA-5facA:
undetectable		 3a2qA-5facA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 178
GLN A 209
LEU A 212
GLU A 208
 None
 1.12A 3h5gA-5facA:
undetectable
3h5gB-5facA:
undetectable		 3h5gA-5facA:
6.00
3h5gB-5facA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  25
VAL A  29
GLY A 244
TYR A 243
TYR A  50
 None
None
None
None
PLP  A 401 (-4.6A)
 1.36A 3hgiA-5facA:
undetectable		 3hgiA-5facA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 VAL A 384
MET A 263
LEU A 351
ILE A 306
 None
 0.99A 3rfmA-5facA:
undetectable		 3rfmA-5facA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 PRO A 307
ILE A 306
GLY A 314
VAL A 325
 None
 0.87A 4a3uB-5facA:
3.7		 4a3uB-5facA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 6 PHE A 182
ALA A 185
PRO A 229
THR A 227
 None
 1.10A 4dtzB-5facA:
undetectable		 4dtzB-5facA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 ILE A 219
ARG A 237
GLY A 239
ALA A 224
 None
PLP  A 401 (-4.2A)
PLP  A 401 (-3.4A)
None
 0.96A 4g0uB-5facA:
undetectable		 4g0uB-5facA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 7 ALA A  58
PRO A  56
LEU A  87
LEU A  69
 None
 0.93A 4iomA-5facA:
3.6		 4iomA-5facA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 8 ILE A 306
ILE A 380
ALA A  18
VAL A 316
 None
 0.78A 4jltA-5facA:
undetectable		 4jltA-5facA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 8 ARG A  17
LEU A 265
ASP A 304
ILE A 306
 None
 1.05A 4k0bA-5facA:
undetectable		 4k0bA-5facA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 369
GLY A 314
ALA A 303
GLY A 305
GLU A 375
 None
 1.29A 4r29C-5facA:
undetectable		 4r29C-5facA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 328
SER A 311
ALA A 310
GLY A 305
ALA A 369
 None
 1.04A 5eeuI-5facA:
undetectable
5eeuJ-5facA:
undetectable		 5eeuI-5facA:
10.98
5eeuJ-5facA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 328
SER A 311
ALA A 310
GLY A 305
ALA A 369
 None
 1.04A 5eevI-5facA:
undetectable
5eevJ-5facA:
undetectable		 5eevI-5facA:
10.98
5eevJ-5facA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 328
SER A 311
ALA A 310
GLY A 305
ALA A 369
 None
 1.04A 5eewI-5facA:
undetectable
5eewJ-5facA:
undetectable		 5eewI-5facA:
10.98
5eewJ-5facA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		3 / 3 VAL A 108
LEU A 160
MET A 119
 None
 0.89A 5ikrA-5facA:
undetectable		 5ikrA-5facA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		4 / 4 ASP A 113
ILE A  93
ARG A  81
ARG A  92
 None
 1.43A 5m67C-5facA:
1.1		 5m67C-5facA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ILE A 251
TYR A 374
GLY A 239
ALA A 241
LEU A 259
 None
PLP  A 401 (-4.2A)
PLP  A 401 (-3.4A)
None
None
 1.23A 5zwrA-5facA:
undetectable		 5zwrA-5facA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 332
GLY A 305
GLY A 301
ARG A 383
SER A 382
 None
 1.20A 6clxA-5facA:
undetectable		 6clxA-5facA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5fac ALANINE RACEMASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 300
ILE A 306
GLY A 314
ILE A 376
ALA A 366
 None
 1.12A 6qxsD-5facA:
undetectable		 6qxsD-5facA:
22.33