SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		5 / 9 GLY A  40
GLU A  59
ILE A  72
ALA A  81
VAL A  77
 None
SAH  A 201 (-2.9A)
None
None
None
 1.40A 2drdA-5fadA:
undetectable		 2drdA-5fadA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		6 / 12 GLY A  36
GLY A  38
GLU A  59
ILE A  60
ASN A  87
PHE A 102
 SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.7A)
SAH  A 201 (-4.9A)
 0.95A 2vdvE-5fadA:
9.5		 2vdvE-5fadA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		6 / 11 GLY A  36
GLY A  38
GLU A  59
ILE A  60
ASN A  87
PHE A 102
 SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.7A)
SAH  A 201 (-4.9A)
 0.95A 2vdvF-5fadA:
9.5		 2vdvF-5fadA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		5 / 12 GLY A  36
GLY A  38
GLU A  59
ILE A  60
ASN A  87
 SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.7A)
 0.38A 3ckkA-5fadA:
10.7		 3ckkA-5fadA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		3 / 3 THR A  12
ASP A  34
GLU A  59
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
 0.25A 3qowA-5fadA:
15.7		 3qowA-5fadA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		4 / 6 LEU A 103
VAL A 107
MET A 110
PHE A  89
 None
 0.73A 3soaA-5fadA:
undetectable		 3soaA-5fadA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		5 / 11 ASP A  34
GLY A  36
GLY A  38
ILE A  42
ASN A  87
 SAH  A 201 (-2.9A)
SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
None
SAH  A 201 (-3.7A)
 0.95A 4dcmA-5fadA:
11.8		 4dcmA-5fadA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		4 / 8 ARG A 124
VAL A  26
ASP A  29
ASP A  30
 None
 0.90A 4xqgA-5fadA:
5.1		 4xqgA-5fadA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		4 / 8 ARG A 124
VAL A  26
ASP A  29
ASP A  30
 None
 0.89A 4xqgB-5fadA:
5.0		 4xqgB-5fadA:
15.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		5 / 12 GLY A  36
ILE A  60
ASN A  87
PHE A  88
LEU A 104
 SAH  A 201 (-3.0A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.7A)
SAH  A 201 (-3.6A)
None
 1.15A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		11 / 12 PRO A  11
GLY A  36
GLY A  38
ARG A  41
ILE A  42
ILE A  60
ASN A  61
ARG A  64
ASN A  87
PHE A  88
PHE A 102
 SAH  A 201 (-4.5A)
SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
None
None
SAH  A 201 (-3.8A)
None
None
SAH  A 201 (-3.7A)
SAH  A 201 (-3.6A)
SAH  A 201 (-4.9A)
 0.48A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		3 / 3 THR A  12
ASP A  34
GLU A  59
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
 0.17A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		4 / 5 THR A  12
ASP A  34
GLU A  59
ASN A  87
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
SAH  A 201 (-3.7A)
 1.01A 5ybbA-5fadA:
10.5		 5ybbA-5fadA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		4 / 7 GLY A  38
GLY A  40
GLU A  59
ASN A  87
 SAH  A 201 (-3.5A)
None
SAH  A 201 (-2.9A)
SAH  A 201 (-3.7A)
 0.53A 5ybbB-5fadA:
10.6		 5ybbB-5fadA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE
(Sulfolobus
islandicus) 		5 / 10 GLY A  40
GLY A  38
ILE A  43
ALA A  68
GLY A  57
 None
SAH  A 201 (-3.5A)
None
None
None
 1.14A 6e5zA-5fadA:
4.2		 6e5zA-5fadA:
23.11