SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5faf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 8 ASN A 206
SER A 205
VAL A 171
PHE A 189
 CA  A 301 ( 4.8A)
None
None
None
 1.11A 2wekA-5fafA:
undetectable		 2wekA-5fafA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 8 ASN A 206
SER A 205
VAL A 171
PHE A 189
 CA  A 301 ( 4.8A)
None
None
None
 1.13A 2wekB-5fafA:
undetectable		 2wekB-5fafA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 4 LEU A 191
ARG A 225
ILE A 197
ILE A 220
 None
None
None
GOL  A 302 (-4.3A)
 0.65A 5dzk2-5fafA:
undetectable
5dzkM-5fafA:
undetectable
5dzkN-5fafA:
undetectable		 5dzk2-5fafA:
4.55
5dzkM-5fafA:
19.80
5dzkN-5fafA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 5 LEU A 191
ARG A 225
ILE A 197
ILE A 220
 None
None
None
GOL  A 302 (-4.3A)
 0.70A 5dzk4-5fafA:
undetectable
5dzkg-5fafA:
undetectable
5dzkm-5fafA:
undetectable
5dzkn-5fafA:
undetectable		 5dzk4-5fafA:
4.55
5dzkg-5fafA:
19.63
5dzkm-5fafA:
19.80
5dzkn-5fafA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 4 ILE A 197
ILE A 220
ARG A 225
LEU A 191
 None
GOL  A 302 (-4.3A)
None
None
 0.78A 5dzkh-5fafA:
undetectable
5dzkn-5fafA:
undetectable
5dzkv-5fafA:
undetectable		 5dzkh-5fafA:
19.80
5dzkn-5fafA:
19.80
5dzkv-5fafA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5faf GELSOLIN
(Homo
sapiens) 		4 / 5 ARG A 225
ILE A 197
ILE A 220
LEU A 191
 None
None
GOL  A 302 (-4.3A)
None
 0.76A 5dzki-5fafA:
undetectable
5dzkj-5fafA:
undetectable
5dzkx-5fafA:
undetectable		 5dzki-5fafA:
19.80
5dzkj-5fafA:
19.80
5dzkx-5fafA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5faf GELSOLIN
(Homo
sapiens) 		5 / 12 ASP A 192
ALA A 173
GLY A 219
ARG A 225
SER A 226
 None
None
GOL  A 302 (-3.3A)
None
None
 1.12A 6clxA-5fafA:
undetectable		 6clxA-5fafA:
16.30