SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 SER A 177
GLY A 201
SER A 218
ILE A 219
LEU A 224
 CIT  A 302 ( 2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.0A)
 0.62A 1uakA-5faiA:
5.0		 1uakA-5faiA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 10 PHE A 178
VAL A 200
GLY A 201
SER A 220
LEU A 224
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.0A)
 0.35A 2v3kA-5faiA:
29.6		 2v3kA-5faiA:
50.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
 None
UNX  A 304 ( 4.1A)
None
None
None
 1.09A 3a50A-5faiA:
undetectable		 3a50A-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 11 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
 None
UNX  A 304 ( 4.1A)
None
None
None
 1.09A 3a50C-5faiA:
undetectable		 3a50C-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
 None
UNX  A 304 ( 4.1A)
None
None
None
 1.11A 3a50E-5faiA:
undetectable		 3a50E-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
 None
UNX  A 304 ( 4.1A)
None
None
None
 1.02A 3a51D-5faiA:
undetectable		 3a51D-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 SER A 177
GLY A 201
SER A 218
ILE A 219
LEU A 224
 CIT  A 302 ( 2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.0A)
 0.70A 3axzA-5faiA:
7.5		 3axzA-5faiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		4 / 7 SER A  91
LEU A  63
ILE A 126
PHE A 133
 None
 1.08A 3ln1C-5faiA:
undetectable		 3ln1C-5faiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		4 / 7 LYS A 232
LEU A 228
THR A 235
ALA A 231
 None
 0.88A 4ik7A-5faiA:
undetectable		 4ik7A-5faiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 12 SER A 177
GLY A 201
SER A 218
ILE A 219
LEU A 224
 CIT  A 302 ( 2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.0A)
 0.64A 4yvgA-5faiA:
undetectable		 4yvgA-5faiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1
(Homo
sapiens) 		5 / 9 LEU A  52
THR A  88
LEU A  92
ILE A 126
LEU A  93
 None
 1.47A 5g48B-5faiA:
undetectable		 5g48B-5faiA:
20.80