SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 5 LEU A 217
LEU A 213
SER A 148
GLY A 154
 None
 0.96A 1a4lC-5fb3A:
undetectable		 1a4lC-5fb3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 154
ALA A 194
ILE A 155
GLY A 219
SER A 190
 None
 1.18A 1c9sN-5fb3A:
undetectable
1c9sO-5fb3A:
undetectable		 1c9sN-5fb3A:
14.29
1c9sO-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 9 GLY A 154
ALA A 194
ILE A 155
GLY A 219
SER A 190
 None
 1.20A 1c9sQ-5fb3A:
undetectable
1c9sR-5fb3A:
undetectable		 1c9sQ-5fb3A:
14.29
1c9sR-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 219
SER A 190
GLY A 154
ALA A 194
ILE A 155
 None
 1.18A 1c9sL-5fb3A:
undetectable
1c9sV-5fb3A:
undetectable		 1c9sL-5fb3A:
14.29
1c9sV-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 4 ARG A 325
ALA A 328
ALA A 304
GLU A 303
 None
 1.23A 1e7bB-5fb3A:
undetectable		 1e7bB-5fb3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 9 GLY A 219
SER A 190
GLY A 154
ALA A 194
ILE A 155
 None
 1.21A 1gtfD-5fb3A:
undetectable
1gtfE-5fb3A:
undetectable		 1gtfD-5fb3A:
14.29
1gtfE-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 GLU A  66
ILE A  60
ILE A  36
TYR A  90
GLU A  58
 SO4  A2004 (-3.8A)
SO4  A2004 (-3.9A)
None
None
SO4  A2004 ( 4.2A)
 1.07A 1ki7A-5fb3A:
undetectable		 1ki7A-5fb3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 GLU A  66
ILE A  60
ILE A  36
TYR A  90
GLU A  58
 SO4  A2004 (-3.8A)
SO4  A2004 (-3.9A)
None
None
SO4  A2004 ( 4.2A)
 1.15A 1ki7B-5fb3A:
undetectable		 1ki7B-5fb3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  19
ALA A 138
LEU A 158
GLY A  16
LEU A 213
 None
 1.04A 1qabF-5fb3A:
undetectable		 1qabF-5fb3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 154
ALA A 194
ILE A 155
GLY A 219
SER A 190
 None
 1.19A 1utdU-5fb3A:
undetectable
1utdV-5fb3A:
undetectable		 1utdU-5fb3A:
14.29
1utdV-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 4 VAL A 248
LEU A 332
ILE A 266
LEU A 262
 None
 1.05A 2byoA-5fb3A:
undetectable		 2byoA-5fb3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 GLU A  66
ILE A  60
ILE A  36
TYR A  90
GLU A  58
 SO4  A2004 (-3.8A)
SO4  A2004 (-3.9A)
None
None
SO4  A2004 ( 4.2A)
 1.08A 2ki5A-5fb3A:
undetectable		 2ki5A-5fb3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 6 TYR A 191
ILE A 273
ILE A 278
ARG A 277
 None
 0.99A 2q8hA-5fb3A:
undetectable		 2q8hA-5fb3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 8 VAL A 260
ASP A 108
LEU A 217
GLY A 154
 None
ZN  A2001 ( 3.8A)
None
None
 0.92A 3af0A-5fb3A:
undetectable		 3af0A-5fb3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 221
SER A 187
LEU A 158
ILE A 218
HIS A 238
 None
None
None
None
ZN  A2001 (-3.6A)
 1.25A 3g9eA-5fb3A:
undetectable		 3g9eA-5fb3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 5 LEU A 217
HIS A 107
HIS A 238
HIS A 256
 None
None
ZN  A2001 (-3.6A)
ZN  A2001 (-3.6A)
 1.24A 4a7bB-5fb3A:
undetectable		 4a7bB-5fb3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 308
LEU A 239
ILE A 163
ALA A 164
ALA A 171
 None
 1.06A 4j14A-5fb3A:
undetectable		 4j14A-5fb3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 VAL A 335
TYR A 269
ILE A 338
LEU A 323
LEU A 305
 None
 1.50A 4jtqA-5fb3A:
undetectable		 4jtqA-5fb3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 5 HIS A 256
VAL A 255
GLU A 245
VAL A 260
 ZN  A2001 (-3.6A)
None
None
None
 1.40A 4p6vB-5fb3A:
undetectable
4p6vE-5fb3A:
undetectable		 4p6vB-5fb3A:
23.20
4p6vE-5fb3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		4 / 6 ASP A 167
TYR A 316
LEU A 170
HIS A 271
 None
 1.11A 4paeA-5fb3A:
undetectable		 4paeA-5fb3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 9 SER A 190
ALA A 164
GLY A 219
GLY A 221
ALA A 223
 None
 1.09A 5d0xK-5fb3A:
undetectable
5d0xL-5fb3A:
undetectable		 5d0xK-5fb3A:
19.30
5d0xL-5fb3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 9 SER A 190
ALA A 164
GLY A 219
GLY A 221
ALA A 223
 None
 1.06A 5d0xY-5fb3A:
undetectable
5d0xZ-5fb3A:
undetectable		 5d0xY-5fb3A:
19.30
5d0xZ-5fb3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 219
SER A 190
GLY A 154
ALA A 194
ILE A 155
 None
 1.17A 5eewA-5fb3A:
undetectable
5eewB-5fb3A:
undetectable		 5eewA-5fb3A:
14.29
5eewB-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 219
SER A 190
GLY A 154
ALA A 194
ILE A 155
 None
 1.17A 5eezA-5fb3A:
undetectable
5eezB-5fb3A:
undetectable		 5eezA-5fb3A:
14.29
5eezB-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 219
SER A 190
GLY A 154
ALA A 194
ILE A 155
 None
 1.17A 5ef0A-5fb3A:
undetectable
5ef0B-5fb3A:
undetectable		 5ef0A-5fb3A:
14.29
5ef0B-5fb3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 11 THR A 103
LEU A 144
PRO A 102
ILE A 110
GLU A 208
 None
 1.49A 5ewjA-5fb3A:
2.5
5ewjB-5fb3A:
4.3		 5ewjA-5fb3A:
21.82
5ewjB-5fb3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 221
GLY A 109
ILE A 193
VAL A 214
GLY A 219
 None
 0.86A 5wyqA-5fb3A:
undetectable		 5wyqA-5fb3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		5 / 12 LEU A 319
LEU A 270
ALA A 331
LEU A 323
LEU A 302
 None
 1.00A 6b0cD-5fb3A:
2.5		 6b0cD-5fb3A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		3 / 3 HIS A 238
HIS A 242
ARG A 312
 ZN  A2001 (-3.6A)
SO4  A2002 (-4.2A)
SO4  A2002 (-2.7A)
 1.05A 6b58A-5fb3A:
2.2		 6b58A-5fb3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		3 / 3 ARG A  32
LYS A  69
TYR A  90
 None
SO4  A2004 (-3.8A)
None
 1.03A 6gnaA-5fb3A:
2.7		 6gnaA-5fb3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Pyrobaculum
calidifontis) 		3 / 3 ARG A  32
LYS A  69
TYR A  90
 None
SO4  A2004 (-3.8A)
None
 1.03A 6gnbA-5fb3A:
2.7		 6gnbA-5fb3A:
24.05