SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		3 / 3 TRP A 278
ALA A 109
VAL A 133
 None
 0.93A 1c4dA-5fbbA:
undetectable
1c4dB-5fbbA:
undetectable		 1c4dA-5fbbA:
3.80
1c4dB-5fbbA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 1c9sD-5fbbA:
undetectable
1c9sE-5fbbA:
undetectable		 1c9sD-5fbbA:
14.80
1c9sE-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.35A 1gtfE-5fbbA:
undetectable
1gtfF-5fbbA:
undetectable		 1gtfE-5fbbA:
14.80
1gtfF-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.30A 1gtnG-5fbbA:
undetectable
1gtnH-5fbbA:
undetectable		 1gtnG-5fbbA:
14.80
1gtnH-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.30A 1gtnS-5fbbA:
undetectable
1gtnT-5fbbA:
undetectable		 1gtnS-5fbbA:
14.80
1gtnT-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		3 / 3 SER A 260
HIS A 145
ASP A  83
 None
ZN  A 403 ( 3.3A)
AMP  A 701 ( 2.6A)
 0.79A 2oxtA-5fbbA:
undetectable		 2oxtA-5fbbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		3 / 3 LEU A 244
TRP A 171
TYR A 246
 NAG  A 502 (-4.0A)
None
None
 1.00A 3aicA-5fbbA:
undetectable		 3aicA-5fbbA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		3 / 3 LEU A 244
TRP A 171
TYR A 246
 NAG  A 502 (-4.0A)
None
None
 0.99A 3aicB-5fbbA:
undetectable		 3aicB-5fbbA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 GLU A 265
LEU A 195
ALA A 179
ALA A 180
 None
 1.01A 3ax9B-5fbbA:
undetectable		 3ax9B-5fbbA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 12 ASP A  83
GLY A 152
HIS A 135
ASP A 139
GLY A 104
 AMP  A 701 ( 2.6A)
AMP  A 701 (-3.4A)
ZN  A 402 ( 3.2A)
ZN  A 402 (-2.5A)
None
 1.11A 4blvA-5fbbA:
undetectable		 4blvA-5fbbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 ASP A 139
ASN A  23
GLU A 177
ASP A  65
 ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
 1.10A 4feuD-5fbbA:
undetectable		 4feuD-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 7 ASP A 139
ASN A  23
GLU A 177
ASP A  65
 ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
 1.09A 4fevB-5fbbA:
undetectable		 4fevB-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 7 ASP A 139
ASN A  23
GLU A 177
ASP A  65
 ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
 1.11A 4fewB-5fbbA:
undetectable		 4fewB-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 ASP A 139
ASN A  23
GLU A 177
ASP A  65
 ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
 1.09A 4gkhD-5fbbA:
undetectable		 4gkhD-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 6 SER A 253
GLU A 178
VAL A 158
THR A 164
 None
 1.31A 4lnxA-5fbbA:
undetectable		 4lnxA-5fbbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 5 ILE A  32
HIS A 145
TYR A 234
VAL A 263
 None
ZN  A 403 ( 3.3A)
None
None
 1.21A 4s0vA-5fbbA:
undetectable		 4s0vA-5fbbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5eeuB-5fbbA:
undetectable
5eeuC-5fbbA:
undetectable		 5eeuB-5fbbA:
14.80
5eeuC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5eevB-5fbbA:
undetectable
5eevC-5fbbA:
undetectable		 5eevB-5fbbA:
14.80
5eevC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5eewB-5fbbA:
undetectable
5eewC-5fbbA:
undetectable		 5eewB-5fbbA:
14.80
5eewC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5eexB-5fbbA:
undetectable
5eexC-5fbbA:
undetectable		 5eexB-5fbbA:
14.80
5eexC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5eeyB-5fbbA:
undetectable
5eeyC-5fbbA:
undetectable		 5eeyB-5fbbA:
14.80
5eeyC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.32A 5eezB-5fbbA:
undetectable
5eezC-5fbbA:
undetectable		 5eezB-5fbbA:
14.80
5eezC-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5ef0B-5fbbA:
undetectable
5ef0C-5fbbA:
undetectable		 5ef0B-5fbbA:
14.80
5ef0C-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5ef1B-5fbbA:
undetectable
5ef1C-5fbbA:
undetectable		 5ef1B-5fbbA:
14.80
5ef1C-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.33A 5ef2B-5fbbA:
undetectable
5ef2C-5fbbA:
undetectable		 5ef2B-5fbbA:
14.80
5ef2C-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 9 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.32A 5ef3B-5fbbA:
undetectable
5ef3C-5fbbA:
undetectable		 5ef3B-5fbbA:
14.80
5ef3C-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 7 GLY A  25
HIS A  26
ASP A  65
ASP A 172
 None
ZN  A 401 ( 3.2A)
PO4  A 601 ( 2.7A)
ZN  A 403 ( 2.1A)
 0.91A 5nnwD-5fbbA:
undetectable		 5nnwD-5fbbA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 7 GLY A  25
HIS A  26
ASP A  65
ASP A 172
 None
ZN  A 401 ( 3.2A)
PO4  A 601 ( 2.7A)
ZN  A 403 ( 2.1A)
 0.98A 5no9D-5fbbA:
undetectable		 5no9D-5fbbA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		5 / 12 TRP A 227
THR A 223
VAL A 221
ASN A 115
VAL A 133
 None
 1.47A 6iblA-5fbbA:
undetectable		 6iblA-5fbbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 0.99A 6mn4A-5fbbA:
undetectable		 6mn4A-5fbbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 0.90A 6mn4B-5fbbA:
undetectable		 6mn4B-5fbbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5fbb NUCLEASE S1
(Aspergillus
oryzae) 		4 / 8 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 1.05A 6mn4D-5fbbA:
undetectable		 6mn4D-5fbbA:
20.14