SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ARG A 666
ASP A 391
ASN A 752
 5WP  A 901 (-2.8A)
None
None
 0.90A 1nbhA-5fbuA:
undetectable		 1nbhA-5fbuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ARG A 666
ASP A 391
ASN A 752
 5WP  A 901 (-2.8A)
None
None
 0.88A 1nbhD-5fbuA:
undetectable		 1nbhD-5fbuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 PHE A 678
ASN A 675
GLY A 672
THR A 523
 None
 0.98A 1ykiA-5fbuA:
undetectable
1ykiB-5fbuA:
undetectable		 1ykiA-5fbuA:
14.17
1ykiB-5fbuA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 THR A 523
PHE A 678
ASN A 675
GLY A 672
 None
 0.96A 1ykiA-5fbuA:
undetectable
1ykiB-5fbuA:
undetectable		 1ykiA-5fbuA:
14.17
1ykiB-5fbuA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 PHE A 678
ASN A 675
GLY A 672
THR A 523
 None
 0.97A 1ykiC-5fbuA:
undetectable
1ykiD-5fbuA:
undetectable		 1ykiC-5fbuA:
14.17
1ykiD-5fbuA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 THR A 523
PHE A 678
ASN A 675
GLY A 672
 None
 0.95A 1ykiC-5fbuA:
undetectable
1ykiD-5fbuA:
undetectable		 1ykiC-5fbuA:
14.17
1ykiD-5fbuA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 LEU A 604
ILE A 605
ASN A 608
TYR A 833
LEU A 528
 None
 1.08A 2bxfB-5fbuA:
3.1		 2bxfB-5fbuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 LEU A 463
PHE A 708
VAL A 715
ALA A 687
 None
 0.75A 2cizA-5fbuA:
undetectable		 2cizA-5fbuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ASN A 608
TYR A 833
SER A 617
 None
 0.85A 2gvcB-5fbuA:
undetectable		 2gvcB-5fbuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ASN A 608
TYR A 833
SER A 617
 None
 0.87A 2gvcE-5fbuA:
undetectable		 2gvcE-5fbuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.10A 2qd5A-5fbuA:
undetectable		 2qd5A-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.05A 2qd5B-5fbuA:
undetectable		 2qd5B-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 LEU A 387
PRO A 392
GLY A 821
GLY A 820
THR A 824
 5WP  A 901 (-4.3A)
None
None
None
None
 1.13A 2uvnA-5fbuA:
undetectable		 2uvnA-5fbuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 SER A 811
ILE A 812
ASP A 794
ARG A 778
 None
 1.12A 2v57A-5fbuA:
2.7		 2v57A-5fbuA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 SER A 811
ILE A 812
ASP A 794
ARG A 778
 None
 1.12A 2v57C-5fbuA:
2.6		 2v57C-5fbuA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 LEU A 366
MET A 359
MET A 750
 None
 0.92A 2vavF-5fbuA:
undetectable		 2vavF-5fbuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ILE A 501
ARG A 660
SER A 515
ALA A 518
ILE A 663
 None
 1.07A 3adsB-5fbuA:
undetectable		 3adsB-5fbuA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.05A 3hcnA-5fbuA:
undetectable		 3hcnA-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 9 ILE A 863
VAL A 838
GLY A 840
ILE A 847
ILE A 765
 None
 0.95A 3s43A-5fbuA:
undetectable		 3s43A-5fbuA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 ALA A 542
PRO A 541
TYR A 540
ARG A 538
 None
 0.98A 3twpA-5fbuA:
2.3		 3twpA-5fbuA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 ALA A 687
LEU A 691
VAL A 692
GLU A 699
 None
 1.07A 4g24A-5fbuA:
undetectable		 4g24A-5fbuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 LEU A 572
LYS A 569
THR A 568
 None
 0.60A 4lj0A-5fbuA:
undetectable		 4lj0A-5fbuA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 GLN A 549
THR A 550
THR A 568
LEU A 606
 None
 0.98A 4lvcB-5fbuA:
undetectable		 4lvcB-5fbuA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		11 / 12 VAL A 333
TYR A 351
PRO A 356
ALA A 357
VAL A 368
LEU A 387
SER A 390
LEU A 478
ILE A 487
MET A 488
MET A 491
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 ( 4.0A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 ( 3.7A)
5WP  A 901 (-4.7A)
None
5WP  A 901 (-4.2A)
5WP  A 901 (-3.6A)
 0.51A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		6 / 12 VAL A 333
TYR A 351
VAL A 368
LEU A 387
ILE A 484
MET A 488
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
None
5WP  A 901 (-4.2A)
 1.06A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		6 / 12 VAL A 333
TYR A 351
VAL A 368
LEU A 387
LEU A 478
ILE A 484
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 (-4.7A)
None
 1.32A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 ILE A 679
PHE A 466
SER A 454
ALA A 683
 None
 1.19A 5msdA-5fbuA:
undetectable		 5msdA-5fbuA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 GLN A 549
THR A 550
THR A 568
LEU A 606
 None
 0.99A 6aphA-5fbuA:
undetectable		 6aphA-5fbuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 GLN A 549
THR A 550
THR A 568
LEU A 606
 None
 1.01A 6f3mA-5fbuA:
undetectable		 6f3mA-5fbuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 GLN A 549
THR A 550
THR A 568
LEU A 606
 None
 1.03A 6f3mC-5fbuA:
undetectable		 6f3mC-5fbuA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 GLN A 549
THR A 550
THR A 568
LEU A 606
 None
 0.98A 6gbnB-5fbuA:
undetectable		 6gbnB-5fbuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 11 ASP A 341
TYR A 800
VAL A 819
GLY A 821
SER A 390
 None
None
None
None
5WP  A 901 ( 3.7A)
 1.40A 6hu9A-5fbuA:
undetectable
6hu9E-5fbuA:
1.8
6hu9I-5fbuA:
undetectable		 6hu9A-5fbuA:
19.72
6hu9E-5fbuA:
12.83
6hu9I-5fbuA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5fbu PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 10 ASP A 341
TYR A 800
VAL A 819
GLY A 821
SER A 390
 None
None
None
None
5WP  A 901 ( 3.7A)
 1.38A 6hu9L-5fbuA:
undetectable
6hu9P-5fbuA:
undetectable
6hu9T-5fbuA:
undetectable		 6hu9L-5fbuA:
19.72
6hu9P-5fbuA:
12.83
6hu9T-5fbuA:
6.35