SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 VAL A2138
LEU A2107
ALA A2133
ILE A2095
ILE A2090
 None
 0.95A 1epbA-5fbyA:
undetectable		 1epbA-5fbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 VAL A2138
LEU A2107
ALA A2133
ILE A2095
ILE A2090
 None
 1.03A 1epbB-5fbyA:
undetectable		 1epbB-5fbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		6 / 11 ARG A1996
GLY A2134
ALA A2135
VAL A2105
GLY A2210
ILE A2211
 None
 1.31A 1hxwB-5fbyA:
undetectable		 1hxwB-5fbyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1717
ILE A1956
VAL A1979
ALA A1978
PHE A1827
 None
 0.93A 1uduB-5fbyA:
undetectable		 1uduB-5fbyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 LEU A1719
ILE A1717
VAL A1979
ALA A1978
PHE A1827
 None
 1.05A 1xp0A-5fbyA:
undetectable		 1xp0A-5fbyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5fby CLEAVED PEPTIDE
SEPARASE
(Chaetomium
thermophilum;
synthetic
construct) 		5 / 12 LEU B  13
LEU A1699
ILE A1702
ILE A1707
SER A1718
 None
 0.66A 2bdmA-5fbyB:
undetectable		 2bdmA-5fbyB:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1717
PHE A1827
ILE A1815
LEU A1971
PRO A1972
 None
 0.94A 2d0kA-5fbyA:
undetectable		 2d0kA-5fbyA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5fby CLEAVED PEPTIDE
SEPARASE
(Chaetomium
thermophilum;
synthetic
construct) 		5 / 11 LEU A1988
LEU A1985
VAL B  15
GLN B  18
ILE A1956
 None
 1.24A 2q6hA-5fbyA:
undetectable		 2q6hA-5fbyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1717
LEU A1744
PHE A1827
ILE A1815
LEU A1971
 None
 1.11A 2w3mA-5fbyA:
undetectable		 2w3mA-5fbyA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 PRO A2076
ALA A2137
PRO A2136
LEU A2021
VAL A2163
 None
 1.03A 2zifB-5fbyA:
undetectable		 2zifB-5fbyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 6 VAL A2208
VAL A2207
ARG A1981
ARG A2199
 None
 0.99A 3bjwF-5fbyA:
1.7		 3bjwF-5fbyA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 PRO A2020
ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 1.06A 3ijxB-5fbyA:
undetectable
3ijxD-5fbyA:
undetectable		 3ijxB-5fbyA:
17.94
3ijxD-5fbyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 PRO A2020
ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 1.06A 3iluB-5fbyA:
undetectable
3iluE-5fbyA:
undetectable		 3iluB-5fbyA:
17.94
3iluE-5fbyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 11 ILE A2077
PRO A2076
SER A2054
GLY A2024
PRO A2020
 None
 1.10A 3iluB-5fbyA:
undetectable
3iluE-5fbyA:
undetectable		 3iluB-5fbyA:
17.94
3iluE-5fbyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5fby SEPARASE
CLEAVED PEPTIDE
(Chaetomium
thermophilum;
synthetic
construct) 		3 / 3 PHE A1695
SER B  11
GLN B  12
 None
 0.85A 3smtA-5fbyA:
undetectable		 3smtA-5fbyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 5 ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 0.94A 3tkdB-5fbyA:
undetectable		 3tkdB-5fbyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 5 ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 0.95A 3tkdA-5fbyA:
undetectable		 3tkdA-5fbyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 7 ALA A2137
PRO A2136
ARG A2102
ALA A2019
 None
 1.02A 3twpB-5fbyA:
undetectable		 3twpB-5fbyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 7 ALA A2137
PRO A2136
ARG A2102
ALA A2019
 None
 0.95A 3twpC-5fbyA:
undetectable		 3twpC-5fbyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1982
VAL A1710
ILE A1702
LEU A1699
VAL A1741
 None
 1.11A 3w68B-5fbyA:
undetectable		 3w68B-5fbyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 LEU A1811
LEU A1771
LEU A1772
ILE A1815
ARG A1981
 None
 1.29A 4f4dA-5fbyA:
undetectable		 4f4dA-5fbyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 9 ALA A2137
LEU A1988
SER A2184
LEU A2185
VAL A2186
 None
 0.89A 4or0A-5fbyA:
undetectable		 4or0A-5fbyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 9 ALA A2137
LEU A1988
SER A2184
LEU A2185
VAL A2186
 None
 0.93A 4or0B-5fbyA:
undetectable		 4or0B-5fbyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5fby CLEAVED PEPTIDE
SEPARASE
(Chaetomium
thermophilum;
synthetic
construct) 		4 / 8 LEU A1733
VAL A1710
TYR A1706
LEU B  16
 None
 0.93A 4pwdC-5fbyA:
undetectable		 4pwdC-5fbyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 7 ASP A2151
ILE A2150
GLY A2109
THR A2037
 None
 1.07A 4zxiA-5fbyA:
undetectable		 4zxiA-5fbyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 6 PHE A1906
HIS A1914
PRO A1688
LEU A1911
 None
 1.39A 5dzka-5fbyA:
undetectable
5dzko-5fbyA:
undetectable		 5dzka-5fbyA:
16.46
5dzko-5fbyA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5fby CLEAVED PEPTIDE
SEPARASE
(Chaetomium
thermophilum;
synthetic
construct) 		5 / 12 ASP A1723
LEU B  16
SER A1720
LEU A1699
THR A1696
 None
 1.37A 5hnxB-5fbyA:
undetectable		 5hnxB-5fbyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5fby SEPARASE
(Chaetomium
thermophilum) 		4 / 8 ILE A1815
LEU A1957
ILE A1717
LEU A1771
 None
 0.98A 5ieoA-5fbyA:
undetectable		 5ieoA-5fbyA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 VAL A2189
ALA A2205
ALA A2206
VAL A2139
THR A2146
 None
 1.02A 5igjA-5fbyA:
undetectable		 5igjA-5fbyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 VAL A2189
ALA A2205
ALA A2206
VAL A2139
THR A2146
 None
 1.03A 5igtA-5fbyA:
undetectable		 5igtA-5fbyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.12A 5igyA-5fbyA:
undetectable		 5igyA-5fbyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 12 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.15A 5ih0A-5fbyA:
undetectable		 5ih0A-5fbyA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 PRO A2052
LEU A2164
PHE A2045
ALA A2154
PHE A2081
 None
 1.43A 5m0oA-5fbyA:
undetectable		 5m0oA-5fbyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 ALA A2188
LEU A2185
LEU A2106
VAL A2163
ILE A2077
 None
 1.10A 5v02B-5fbyA:
1.9
5v02R-5fbyA:
undetectable		 5v02B-5fbyA:
12.50
5v02R-5fbyA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 10 PRO A2020
ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 1.15A 5weoA-5fbyA:
undetectable
5weoD-5fbyA:
3.8		 5weoA-5fbyA:
20.35
5weoD-5fbyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 9 PRO A2020
ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 1.15A 5weoB-5fbyA:
3.8
5weoC-5fbyA:
undetectable		 5weoB-5fbyA:
20.35
5weoC-5fbyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5fby SEPARASE
(Chaetomium
thermophilum) 		5 / 9 ILE A2077
PRO A2076
SER A2054
GLY A2024
PRO A2020
 None
 1.15A 5weoA-5fbyA:
undetectable
5weoD-5fbyA:
3.7		 5weoA-5fbyA:
20.35
5weoD-5fbyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5fby SEPARASE
CLEAVED PEPTIDE
(Chaetomium
thermophilum;
synthetic
construct) 		4 / 5 VAL A1958
LEU B  16
HIS B  10
THR A1731
 None
 1.46A 6dyoA-5fbyA:
undetectable		 6dyoA-5fbyA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5fby CLEAVED PEPTIDE
SEPARASE
(Chaetomium
thermophilum;
synthetic
construct) 		5 / 10 VAL A1710
LEU A1709
LEU B  16
GLY A1736
VAL A1716
 None
 0.98A 6eu9B-5fbyA:
undetectable		 6eu9B-5fbyA:
11.51