SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ALA A 315
VAL A  40
TRP A 104
 None
 0.93A 1av2A-5fcaA:
undetectable
1av2B-5fcaA:
undetectable		 1av2A-5fcaA:
5.50
1av2B-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ALA A 315
VAL A  40
TRP A 104
 None
 0.78A 1c4dC-5fcaA:
undetectable
1c4dD-5fcaA:
undetectable		 1c4dC-5fcaA:
5.50
1c4dD-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 TRP A 104
ALA A 315
VAL A  40
 None
 0.88A 1c4dC-5fcaA:
undetectable
1c4dD-5fcaA:
undetectable		 1c4dC-5fcaA:
5.50
1c4dD-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.11A 1hrkA-5fcaA:
undetectable		 1hrkA-5fcaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ASP A 107
HIS A 149
HIS A  44
 ZN  A 502 ( 2.7A)
ZN  A 503 (-3.8A)
ZN  A 501 (-3.3A)
 0.66A 1oe1A-5fcaA:
undetectable		 1oe1A-5fcaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ASP A 107
HIS A 149
HIS A  44
 ZN  A 502 ( 2.7A)
ZN  A 503 (-3.8A)
ZN  A 501 (-3.3A)
 0.65A 1oe3A-5fcaA:
undetectable		 1oe3A-5fcaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 7 GLY A 147
HIS A 290
TYR A 211
PRO A 213
 None
ZN  A 502 (-3.3A)
None
None
 1.19A 1th6A-5fcaA:
undetectable		 1th6A-5fcaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ALA A 315
VAL A  40
TRP A 104
 None
 0.93A 1w5uA-5fcaA:
undetectable
1w5uB-5fcaA:
undetectable		 1w5uA-5fcaA:
5.50
1w5uB-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 TRP A 104
ALA A 315
VAL A  40
 None
 1.00A 1w5uA-5fcaA:
undetectable
1w5uB-5fcaA:
undetectable		 1w5uA-5fcaA:
5.50
1w5uB-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 ARG A 277
LEU A 432
PHE A 287
TYR A 288
GLY A 285
 None
 1.09A 2bxmA-5fcaA:
undetectable		 2bxmA-5fcaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 10 ARG A 277
LEU A 432
PHE A 287
TYR A 288
GLY A 285
 None
 1.18A 2bxqA-5fcaA:
undetectable		 2bxqA-5fcaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 5 TYR A 337
TYR A 245
ILE A 202
GLY A 340
 None
 1.37A 2du8G-5fcaA:
undetectable		 2du8G-5fcaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 5 TYR A 337
TYR A 245
ILE A 202
GLY A 340
 None
 1.31A 2du8J-5fcaA:
undetectable		 2du8J-5fcaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.11A 2hrcA-5fcaA:
undetectable		 2hrcA-5fcaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.09A 2hrcB-5fcaA:
undetectable		 2hrcB-5fcaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 TRP A 104
ALA A 315
VAL A  40
 None
 0.87A 2izqC-5fcaA:
undetectable
2izqD-5fcaA:
undetectable		 2izqC-5fcaA:
5.50
2izqD-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.16A 2po7A-5fcaA:
undetectable		 2po7A-5fcaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 6 LEU A 371
THR A 372
ARG A 333
LEU A 345
 None
 1.09A 2wm3A-5fcaA:
undetectable		 2wm3A-5fcaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ASP A 107
HIS A 149
HIS A  44
 ZN  A 502 ( 2.7A)
ZN  A 503 (-3.8A)
ZN  A 501 (-3.3A)
 0.67A 2xxgA-5fcaA:
undetectable		 2xxgA-5fcaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 ASP A 107
HIS A 149
HIS A  44
 ZN  A 502 ( 2.7A)
ZN  A 503 (-3.8A)
ZN  A 501 (-3.3A)
 0.67A 2xxgC-5fcaA:
undetectable		 2xxgC-5fcaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.31A 2zweA-5fcaA:
undetectable
2zweB-5fcaA:
undetectable		 2zweA-5fcaA:
22.05
2zweB-5fcaA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.32A 2zwfA-5fcaA:
undetectable
2zwfB-5fcaA:
undetectable		 2zwfA-5fcaA:
22.05
2zwfB-5fcaA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.33A 2zwgA-5fcaA:
undetectable
2zwgB-5fcaA:
undetectable		 2zwgA-5fcaA:
22.05
2zwgB-5fcaA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A 136
GLN A 134
TYR A  82
PHE A  89
LEU A  43
 None
None
NAG  A 508 (-2.7A)
None
None
 1.27A 3gwuA-5fcaA:
undetectable		 3gwuA-5fcaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 LEU A 296
LEU A 385
GLN A 390
TYR A 403
THR A 394
 None
None
GOL  A 519 (-3.3A)
None
None
 1.00A 3gwuA-5fcaA:
undetectable		 3gwuA-5fcaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 TRP A 104
ALA A 315
VAL A  40
 None
 0.95A 3l8lC-5fcaA:
undetectable
3l8lD-5fcaA:
undetectable		 3l8lC-5fcaA:
5.50
3l8lD-5fcaA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 7 ASN A 208
ASP A  42
HIS A 292
HIS A  44
 None
ZN  A 501 (-3.1A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.3A)
 1.00A 3t01A-5fcaA:
undetectable		 3t01A-5fcaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 7 THR A 317
ASN A 328
ASP A  79
HIS A 111
HIS A  44
 None
None
GOL  A 518 ( 4.9A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 1.33A 3t01A-5fcaA:
undetectable		 3t01A-5fcaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 5 LEU A  86
ALA A  88
MET A 129
THR A 132
 None
None
None
NAG  A 508 ( 4.3A)
 1.16A 3vasB-5fcaA:
undetectable		 3vasB-5fcaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 9 TYR A 165
LEU A 157
LEU A 146
GLY A 147
VAL A 122
 None
 1.40A 4c9kA-5fcaA:
undetectable		 4c9kA-5fcaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 TYR A 279
THR A 233
VAL A 244
ILE A 275
 None
 1.07A 4jx1F-5fcaA:
undetectable		 4jx1F-5fcaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		6 / 12 LEU A 432
VAL A 252
VAL A 298
PHE A 276
LEU A 344
VAL A 312
 None
 1.44A 4nc3A-5fcaA:
undetectable		 4nc3A-5fcaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 LYS A 402
ARG A 333
VAL A 348
 None
None
GOL  A 520 ( 4.5A)
 0.89A 4x3uA-5fcaA:
undetectable
4x3uB-5fcaA:
undetectable		 4x3uA-5fcaA:
10.73
4x3uB-5fcaA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 8 LEU A 205
THR A 233
LEU A 234
LEU A 230
 None
 0.59A 4z90F-5fcaA:
undetectable
4z90G-5fcaA:
undetectable
4z90H-5fcaA:
undetectable
4z90I-5fcaA:
undetectable
4z90J-5fcaA:
undetectable		 4z90F-5fcaA:
21.20
4z90G-5fcaA:
21.20
4z90H-5fcaA:
21.20
4z90I-5fcaA:
21.20
4z90J-5fcaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 7 ILE A 283
PHE A 276
VAL A 244
ILE A 203
 None
 0.71A 4zzbC-5fcaA:
undetectable
4zzbD-5fcaA:
undetectable		 4zzbC-5fcaA:
22.55
4zzbD-5fcaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 6 LYS A 383
GLY A 304
SER A 300
LEU A 307
 None
 1.28A 5bphD-5fcaA:
undetectable		 5bphD-5fcaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 PRO A 213
HIS A  44
HIS A 111
ASP A 107
TYR A 211
 None
ZN  A 501 (-3.3A)
GOL  A 518 (-2.7A)
ZN  A 502 ( 2.7A)
None
 1.49A 5eenB-5fcaA:
undetectable		 5eenB-5fcaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 5 GLY A 289
PRO A 330
THR A  41
THR A 291
 None
 1.18A 5h5fA-5fcaA:
undetectable		 5h5fA-5fcaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 12 GLY A 289
ALA A 263
LEU A 255
GLY A 147
ASP A 107
 None
None
None
None
ZN  A 502 ( 2.7A)
 0.85A 5kb5A-5fcaA:
2.0		 5kb5A-5fcaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5mhwA-5fcaA:
undetectable		 5mhwA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5mhxA-5fcaA:
undetectable		 5mhxA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5mhyA-5fcaA:
undetectable		 5mhyA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5mhzA-5fcaA:
undetectable		 5mhzA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5mi1A-5fcaA:
undetectable		 5mi1A-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5mi2A-5fcaA:
undetectable		 5mi2A-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5miaA-5fcaA:
undetectable		 5miaA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5mibA-5fcaA:
undetectable		 5mibA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5micA-5fcaA:
undetectable		 5micA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.83A 5midA-5fcaA:
undetectable		 5midA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5mieA-5fcaA:
undetectable		 5mieA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 ASP A 107
HIS A 249
HIS A 290
HIS A 149
 ZN  A 502 ( 2.7A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 503 (-3.8A)
 1.49A 5ncdD-5fcaA:
2.0		 5ncdD-5fcaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 6 ASP A 107
HIS A  44
HIS A 292
HIS A 249
 ZN  A 502 ( 2.7A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.4A)
ZN  A 502 (-3.3A)
 1.01A 5nelB-5fcaA:
undetectable
5nelC-5fcaA:
undetectable		 5nelB-5fcaA:
19.15
5nelC-5fcaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 5 VAL A 250
HIS A 111
LEU A 157
ASP A  42
 None
GOL  A 518 (-2.7A)
None
ZN  A 501 (-3.1A)
 1.47A 5vcvA-5fcaA:
undetectable		 5vcvA-5fcaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 SER A  61
THR A 327
ASP A 412
ASP A  75
 None
 1.22A 5vimA-5fcaA:
undetectable		 5vimA-5fcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		4 / 4 SER A  61
THR A 327
ASP A 412
ASP A  75
 None
 1.20A 5vimB-5fcaA:
undetectable		 5vimB-5fcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.30A 5z0fA-5fcaA:
undetectable
5z0fB-5fcaA:
undetectable		 5z0fA-5fcaA:
15.34
5z0fB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.34A 5z0gA-5fcaA:
undetectable
5z0gB-5fcaA:
undetectable		 5z0gA-5fcaA:
15.34
5z0gB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.37A 5z0hA-5fcaA:
undetectable
5z0hB-5fcaA:
undetectable		 5z0hA-5fcaA:
15.34
5z0hB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.34A 5z0iA-5fcaA:
undetectable
5z0iB-5fcaA:
undetectable		 5z0iA-5fcaA:
15.34
5z0iB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.32A 5z0jA-5fcaA:
undetectable
5z0jB-5fcaA:
undetectable		 5z0jA-5fcaA:
15.34
5z0jB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.34A 5z0kA-5fcaA:
undetectable
5z0kB-5fcaA:
undetectable		 5z0kA-5fcaA:
15.34
5z0kB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.37A 5z0lA-5fcaA:
undetectable
5z0lB-5fcaA:
undetectable		 5z0lA-5fcaA:
15.34
5z0lB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
ASP A  46
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.18A 5z0mA-5fcaA:
undetectable
5z0mB-5fcaA:
undetectable		 5z0mA-5fcaA:
15.34
5z0mB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		5 / 11 HIS A 292
HIS A 149
HIS A 111
VAL A 112
PRO A  47
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
None
NAG  A 508 ( 4.9A)
 1.37A 5z0mA-5fcaA:
undetectable
5z0mB-5fcaA:
undetectable		 5z0mA-5fcaA:
15.34
5z0mB-5fcaA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Mus
musculus) 		3 / 3 HIS A 149
HIS A 111
HIS A  44
 ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.71A 6giqa-5fcaA:
undetectable		 6giqa-5fcaA:
20.07