SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5fcd MCCD
(Escherichia
coli) 		5 / 11 PHE A 119
GLY A 149
LEU A 112
GLU A 140
HIS A 142
 None
 1.38A 1mjqA-5fcdA:
undetectable
1mjqB-5fcdA:
undetectable		 1mjqA-5fcdA:
17.62
1mjqB-5fcdA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fcd MCCD
(Escherichia
coli) 		4 / 8 THR A 118
PHE A 114
GLU A  77
GLY A  78
 None
 0.98A 1ykiA-5fcdA:
undetectable
1ykiB-5fcdA:
undetectable		 1ykiA-5fcdA:
22.91
1ykiB-5fcdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fcd MCCD
(Escherichia
coli) 		4 / 8 GLU A  77
GLY A  78
THR A 118
PHE A 114
 None
 1.00A 1ykiC-5fcdA:
undetectable
1ykiD-5fcdA:
undetectable		 1ykiC-5fcdA:
22.91
1ykiD-5fcdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fcd MCCD
(Escherichia
coli) 		4 / 8 THR A 118
PHE A 114
GLU A  77
GLY A  78
 None
 0.96A 1ykiC-5fcdA:
undetectable
1ykiD-5fcdA:
undetectable		 1ykiC-5fcdA:
22.91
1ykiD-5fcdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5fcd MCCD
(Escherichia
coli) 		4 / 5 TYR A 158
GLN A 253
ILE A 246
LEU A 250
 None
 1.06A 3ls4L-5fcdA:
undetectable		 3ls4L-5fcdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fcd MCCD
(Escherichia
coli) 		5 / 12 ALA A  98
CYH A  68
GLY A  73
ILE A  39
LEU A 123
 None
 1.14A 4n48B-5fcdA:
8.5		 4n48B-5fcdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5fcd MCCD
(Escherichia
coli) 		3 / 3 VAL A 198
THR A 196
ARG A 265
 None
 0.76A 5b2sB-5fcdA:
undetectable		 5b2sB-5fcdA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5fcd MCCD
(Escherichia
coli) 		3 / 3 TYR A 104
ASP A  80
ASP A  56
 None
 0.84A 5x6yA-5fcdA:
4.0		 5x6yA-5fcdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5fcd MCCD
(Escherichia
coli) 		5 / 12 ILE A 131
ASN A 139
LEU A 135
ILE A  79
LEU A 112
 None
None
CL  A 301 (-4.5A)
None
None
 1.14A 6dwnC-5fcdA:
undetectable		 6dwnC-5fcdA:
13.16