SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		3 / 3 TRP A 243
ARG A 260
THR A 242
 None
 0.88A 1df7A-5fclA:
undetectable		 1df7A-5fclA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 PHE A 123
LEU A 270
VAL A 140
ALA A 132
ALA A 136
 None
 1.03A 1q23A-5fclA:
undetectable
1q23B-5fclA:
undetectable		 1q23A-5fclA:
20.54
1q23B-5fclA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 LEU A  61
VAL A  67
PHE A  75
VAL A  59
VAL A  31
 None
 1.25A 1q23H-5fclA:
undetectable
1q23I-5fclA:
undetectable		 1q23H-5fclA:
20.54
1q23I-5fclA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 7 ALA A 234
ALA A 238
THR A 242
LEU A 314
 None
 0.79A 2wx2A-5fclA:
undetectable		 2wx2A-5fclA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 8 ALA A 234
ALA A 238
THR A 242
LEU A 314
 None
 0.89A 2wx2B-5fclA:
undetectable		 2wx2B-5fclA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 7 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.89A 3bjwB-5fclA:
undetectable		 3bjwB-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 6 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.87A 3bjwE-5fclA:
undetectable		 3bjwE-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 7 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.83A 3bjwF-5fclA:
undetectable		 3bjwF-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 7 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.89A 3bjwH-5fclA:
undetectable		 3bjwH-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		3 / 3 GLU A 191
ASP A 273
ASP A 266
 None
 0.70A 3jb2A-5fclA:
undetectable		 3jb2A-5fclA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 8 ALA A 234
ALA A 238
THR A 242
LEU A 314
 None
 0.77A 3khmA-5fclA:
undetectable		 3khmA-5fclA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 8 ALA A 234
ALA A 238
THR A 242
LEU A 314
 None
 0.82A 3l4dD-5fclA:
undetectable		 3l4dD-5fclA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 LEU A 227
ASN A 231
LEU A 233
ALA A 234
ALA A 300
 None
 0.91A 4fn9A-5fclA:
undetectable		 4fn9A-5fclA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 ALA A 300
LEU A 298
GLY A 230
ALA A 234
TYR A 235
 None
 1.16A 4pclA-5fclA:
undetectable		 4pclA-5fclA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 7 ALA A 202
ILE A 282
LEU A 154
PHE A 160
 None
 0.98A 4uymA-5fclA:
0.4		 4uymA-5fclA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 11 LEU A 201
LEU A 198
GLU A 165
LEU A 167
LEU A 171
 None
 1.14A 4wg0F-5fclA:
undetectable
4wg0G-5fclA:
undetectable
4wg0H-5fclA:
undetectable		 4wg0F-5fclA:
4.20
4wg0G-5fclA:
4.20
4wg0H-5fclA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 11 LEU A 171
GLU A 165
LEU A 167
LEU A 201
LEU A 198
 None
 1.11A 4wg0G-5fclA:
undetectable
4wg0H-5fclA:
undetectable
4wg0I-5fclA:
undetectable		 4wg0G-5fclA:
4.20
4wg0H-5fclA:
4.20
4wg0I-5fclA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 11 LEU A 171
GLU A 165
LEU A 167
LEU A 201
LEU A 198
 None
 1.13A 4wg0K-5fclA:
undetectable
4wg0L-5fclA:
undetectable
4wg0M-5fclA:
undetectable		 4wg0K-5fclA:
4.20
4wg0L-5fclA:
4.20
4wg0M-5fclA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 244
LEU A 245
ASP A 308
ILE A 311
GLY A 312
 None
 1.04A 4y8wA-5fclA:
undetectable		 4y8wA-5fclA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 TYR A  23
LEU A 298
LEU A 233
PHE A  93
THR A  63
 None
 1.38A 5ieoA-5fclA:
undetectable		 5ieoA-5fclA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		4 / 6 ARG A 296
PRO A 278
ARG A 153
ILE A 282
 None
 1.33A 5ih0A-5fclA:
undetectable		 5ih0A-5fclA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 267
ASP A 266
SER A 241
PRO A 248
GLY A 250
 None
 1.48A 5m50B-5fclA:
undetectable		 5m50B-5fclA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pectobacterium
atrosepticum) 		5 / 12 LEU A 247
ASP A 119
ALA A 133
LEU A 263
LEU A 270
 None
 1.08A 6ew0F-5fclA:
undetectable		 6ew0F-5fclA:
12.31