SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.70A 1tnlA-5fcrA:
13.0		 1tnlA-5fcrA:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		3 / 3 LYS A  16
ASP A  60
ASP A 194
 None
 0.91A 2br4D-5fcrA:
undetectable		 2br4D-5fcrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		5 / 12 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.67A 2w26A-5fcrA:
11.2		 2w26A-5fcrA:
29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.71A 3rxhA-5fcrA:
12.9		 3rxhA-5fcrA:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 7 ASP A 194
GLY A  44
THR A  45
THR A 190
 None
 0.74A 4ac9C-5fcrA:
2.3		 4ac9C-5fcrA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 7 ASP A 194
GLY A  44
THR A  45
THR A 190
 None
 0.77A 4acaC-5fcrA:
2.5		 4acaC-5fcrA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 7 ASP A 102
THR A 214
SER A  98
HIS A  57
 None
 1.36A 4o4dA-5fcrA:
undetectable		 4o4dA-5fcrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		5 / 12 GLY A  43
GLY A 140
GLY A 142
SER A 197
ALA A  31
 None
 0.94A 4uciA-5fcrA:
undetectable		 4uciA-5fcrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		5 / 12 GLY A  43
GLY A 140
GLY A 142
SER A 197
ALA A  31
 None
 0.95A 4uciB-5fcrA:
undetectable		 4uciB-5fcrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		5 / 12 GLY A  43
GLY A 140
GLY A 142
SER A 197
ALA A  31
 None
 0.92A 4uckA-5fcrA:
undetectable		 4uckA-5fcrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5fcr COMPLEMENT FACTOR D
(Mus
musculus) 		4 / 6 GLY A 211
SER A 197
THR A  45
VAL A 209
 None
 0.88A 5ysiA-5fcrA:
undetectable		 5ysiA-5fcrA:
21.37