SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLY H 118
THR H  11
THR H 107
THR H 146
 None
 0.90A 1c9sT-5fcsH:
undetectable
1c9sU-5fcsH:
undetectable		 1c9sT-5fcsH:
14.23
1c9sU-5fcsH:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.25A 1zzrA-5fcsH:
undetectable
1zzrB-5fcsH:
undetectable		 1zzrA-5fcsH:
18.87
1zzrB-5fcsH:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.96A 1zzrA-5fcsL:
undetectable
1zzrB-5fcsL:
undetectable		 1zzrA-5fcsL:
20.05
1zzrB-5fcsL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.26A 1zzrA-5fcsH:
undetectable
1zzrB-5fcsH:
undetectable		 1zzrA-5fcsH:
18.87
1zzrB-5fcsH:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.98A 1zzrA-5fcsL:
undetectable
1zzrB-5fcsL:
undetectable		 1zzrA-5fcsL:
20.05
1zzrB-5fcsL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.24A 1zzuA-5fcsH:
undetectable
1zzuB-5fcsH:
undetectable		 1zzuA-5fcsH:
18.87
1zzuB-5fcsH:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.97A 1zzuA-5fcsL:
undetectable
1zzuB-5fcsL:
undetectable		 1zzuA-5fcsL:
20.05
1zzuB-5fcsL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.25A 1zzuA-5fcsH:
undetectable
1zzuB-5fcsH:
undetectable		 1zzuA-5fcsH:
18.87
1zzuB-5fcsH:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.97A 1zzuA-5fcsL:
undetectable
1zzuB-5fcsL:
undetectable		 1zzuA-5fcsL:
20.05
1zzuB-5fcsL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 SER H 153
SER H 221
TRP H 226
ASP L  51
 None
 1.32A 3bc9A-5fcsH:
6.8		 3bc9A-5fcsH:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.98A 3dqrA-5fcsL:
undetectable
3dqrB-5fcsL:
undetectable		 3dqrA-5fcsL:
19.95
3dqrB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 1.02A 3dqrA-5fcsL:
undetectable
3dqrB-5fcsL:
undetectable		 3dqrA-5fcsL:
19.95
3dqrB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.19A 3jx2A-5fcsH:
undetectable
3jx2B-5fcsH:
undetectable		 3jx2A-5fcsH:
18.63
3jx2B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.95A 3jx2A-5fcsL:
undetectable
3jx2B-5fcsL:
undetectable		 3jx2A-5fcsL:
19.95
3jx2B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.25A 3jx2A-5fcsH:
undetectable
3jx2B-5fcsH:
undetectable		 3jx2A-5fcsH:
18.63
3jx2B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.96A 3jx2A-5fcsL:
undetectable
3jx2B-5fcsL:
undetectable		 3jx2A-5fcsL:
19.95
3jx2B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.25A 3jx3A-5fcsH:
undetectable
3jx3B-5fcsH:
undetectable		 3jx3A-5fcsH:
18.63
3jx3B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 1.00A 3jx3A-5fcsL:
undetectable
3jx3B-5fcsL:
undetectable		 3jx3A-5fcsL:
19.95
3jx3B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.23A 3jx3A-5fcsH:
undetectable
3jx3B-5fcsH:
undetectable		 3jx3A-5fcsH:
18.63
3jx3B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.95A 3jx3A-5fcsL:
undetectable
3jx3B-5fcsL:
undetectable		 3jx3A-5fcsL:
19.95
3jx3B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.30A 3jx4A-5fcsH:
undetectable
3jx4B-5fcsH:
undetectable		 3jx4A-5fcsH:
18.63
3jx4B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.98A 3jx4A-5fcsL:
undetectable
3jx4B-5fcsL:
undetectable		 3jx4A-5fcsL:
19.95
3jx4B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.22A 3jx5A-5fcsH:
undetectable
3jx5B-5fcsH:
undetectable		 3jx5A-5fcsH:
18.63
3jx5B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.96A 3jx5A-5fcsL:
undetectable
3jx5B-5fcsL:
undetectable		 3jx5A-5fcsL:
19.95
3jx5B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.97A 3jx5A-5fcsL:
undetectable
3jx5B-5fcsL:
undetectable		 3jx5A-5fcsL:
19.95
3jx5B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.18A 3jx6A-5fcsH:
undetectable
3jx6B-5fcsH:
undetectable		 3jx6A-5fcsH:
18.63
3jx6B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.91A 3jx6A-5fcsL:
undetectable
3jx6B-5fcsL:
undetectable		 3jx6A-5fcsL:
19.95
3jx6B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.24A 3jx6A-5fcsH:
undetectable
3jx6B-5fcsH:
undetectable		 3jx6A-5fcsH:
18.63
3jx6B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.94A 3jx6A-5fcsL:
undetectable
3jx6B-5fcsL:
undetectable		 3jx6A-5fcsL:
19.95
3jx6B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.19A 3nljA-5fcsH:
undetectable
3nljB-5fcsH:
undetectable		 3nljA-5fcsH:
18.63
3nljB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.91A 3nljA-5fcsL:
undetectable
3nljB-5fcsL:
undetectable		 3nljA-5fcsL:
19.95
3nljB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.22A 3nljA-5fcsH:
undetectable
3nljB-5fcsH:
undetectable		 3nljA-5fcsH:
18.63
3nljB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.92A 3nljA-5fcsL:
undetectable
3nljB-5fcsL:
undetectable		 3nljA-5fcsL:
19.95
3nljB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.21A 3nlpA-5fcsH:
undetectable
3nlpB-5fcsH:
undetectable		 3nlpA-5fcsH:
18.63
3nlpB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.93A 3nlpA-5fcsL:
undetectable
3nlpB-5fcsL:
undetectable		 3nlpA-5fcsL:
19.95
3nlpB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.97A 3nlpA-5fcsL:
undetectable
3nlpB-5fcsL:
undetectable		 3nlpA-5fcsL:
19.95
3nlpB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.19A 3nlqA-5fcsH:
undetectable
3nlqB-5fcsH:
undetectable		 3nlqA-5fcsH:
18.63
3nlqB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.90A 3nlqA-5fcsL:
undetectable
3nlqB-5fcsL:
undetectable		 3nlqA-5fcsL:
19.95
3nlqB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.92A 3nlqA-5fcsL:
undetectable
3nlqB-5fcsL:
undetectable		 3nlqA-5fcsL:
19.95
3nlqB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.22A 3nlrA-5fcsH:
undetectable
3nlrB-5fcsH:
undetectable		 3nlrA-5fcsH:
18.63
3nlrB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.94A 3nlrA-5fcsL:
undetectable
3nlrB-5fcsL:
undetectable		 3nlrA-5fcsL:
19.95
3nlrB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.95A 3nlrA-5fcsL:
undetectable
3nlrB-5fcsL:
undetectable		 3nlrA-5fcsL:
19.95
3nlrB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 GLN H   6
PHE H 100
GLY H 101
GLY H  51
 None
 0.86A 3v3nB-5fcsH:
undetectable		 3v3nB-5fcsH:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 GLN H   6
PHE H 100
GLY H 101
GLY H  51
 None
 0.86A 3v3nC-5fcsH:
undetectable		 3v3nC-5fcsH:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5fcs DIABODY
(Homo
sapiens) 		5 / 11 GLN L 157
PHE H 100
GLY L 162
PRO H  46
GLY H  48
 None
 1.50A 3v3oC-5fcsL:
undetectable		 3v3oC-5fcsL:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.25A 4cx3A-5fcsH:
undetectable
4cx3B-5fcsH:
undetectable		 4cx3A-5fcsH:
18.63
4cx3B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.98A 4cx3A-5fcsL:
undetectable
4cx3B-5fcsL:
undetectable		 4cx3A-5fcsL:
19.95
4cx3B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.24A 4cx3A-5fcsH:
undetectable
4cx3B-5fcsH:
undetectable		 4cx3A-5fcsH:
18.63
4cx3B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.96A 4cx3A-5fcsL:
undetectable
4cx3B-5fcsL:
undetectable		 4cx3A-5fcsL:
19.95
4cx3B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.26A 4cx4A-5fcsH:
undetectable
4cx4B-5fcsH:
undetectable		 4cx4A-5fcsH:
18.63
4cx4B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.98A 4cx4A-5fcsL:
undetectable
4cx4B-5fcsL:
undetectable		 4cx4A-5fcsL:
19.95
4cx4B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.96A 4cx4A-5fcsL:
undetectable
4cx4B-5fcsL:
undetectable		 4cx4A-5fcsL:
19.95
4cx4B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5fcs DIABODY
DIABODY
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU L 164
ARG L 156
GLN H   1
 None
 0.96A 4rtbA-5fcsL:
undetectable		 4rtbA-5fcsL:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5fcs DIABODY
(Homo
sapiens) 		5 / 12 THR L  81
VAL L 109
GLN L 121
GLU L 119
ILE L  76
 None
 1.49A 4s0vA-5fcsL:
undetectable		 4s0vA-5fcsL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5fcs DIABODY
(Homo
sapiens) 		5 / 12 THR L  81
VAL L 109
GLN L 121
GLU L 119
TYR L  87
 None
 1.48A 4s0vA-5fcsL:
undetectable		 4s0vA-5fcsL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5fcs DIABODY
(Homo
sapiens) 		3 / 3 ALA H  91
TRP H  98
VAL H  99
 None
 0.30A 4w9nC-5fcsH:
undetectable		 4w9nC-5fcsH:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5fcs DIABODY
(Homo
sapiens) 		5 / 7 TYR L  33
SER L  35
TYR L  37
TYR L  50
PRO L  56
 None
 0.61A 5aclA-5fcsL:
21.5		 5aclA-5fcsL:
64.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU H  85
VAL H 108
ARG H  63
VAL H  18
 None
 1.22A 5addA-5fcsH:
undetectable
5addB-5fcsH:
undetectable		 5addA-5fcsH:
18.63
5addB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.90A 5addA-5fcsL:
undetectable
5addB-5fcsL:
undetectable		 5addA-5fcsL:
19.95
5addB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.89A 5adeA-5fcsL:
undetectable
5adeB-5fcsL:
undetectable		 5adeA-5fcsL:
19.95
5adeB-5fcsL:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 GLY L  90
TRP L  92
SER L  97
PHE L 101
 None
 0.82A 5alcL-5fcsL:
22.8		 5alcL-5fcsL:
52.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.25A 5g0pA-5fcsH:
undetectable
5g0pB-5fcsH:
undetectable		 5g0pA-5fcsH:
18.63
5g0pB-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.96A 5g0pA-5fcsL:
undetectable
5g0pB-5fcsL:
undetectable		 5g0pA-5fcsL:
19.95
5g0pB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fcs DIABODY
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
None
SO4  L 304 ( 4.9A)
None
 0.98A 5g0pA-5fcsL:
undetectable
5g0pB-5fcsL:
undetectable		 5g0pA-5fcsL:
19.95
5g0pB-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5fcs DIABODY
DIABODY
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA H 222
GLY L  90
ASP H 218
GLY H 151
LEU H 122
 None
 1.14A 5wwsA-5fcsH:
undetectable		 5wwsA-5fcsH:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5fcs DIABODY
(Homo
sapiens) 		4 / 8 GLY H 151
ILE H 152
ASP H 218
ASP H 224
 None
 1.02A 6ag0C-5fcsH:
undetectable		 6ag0C-5fcsH:
17.73