SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5fcy RED CAROTENOID
PROTEIN (RCP)
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE A 101
LEU A  74
TYR A  90
LEU A  27
MET A 109
 None
None
None
BCR  A 201 (-3.8A)
BCR  A 201 (-2.8A)
 1.42A 1p33B-5fcyA:
undetectable		 1p33B-5fcyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5fcy RED CAROTENOID
PROTEIN (RCP)
(Nostoc
sp.
PCC
7120) 		5 / 9 LEU A 131
ILE A 134
GLY A 133
LEU A 123
SER A 124
 None
 1.01A 3ai9X-5fcyA:
undetectable		 3ai9X-5fcyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 5fcy RED CAROTENOID
PROTEIN (RCP)
(Nostoc
sp.
PCC
7120) 		5 / 10 TRP A 102
MET A 153
GLN A  73
LEU A  74
LEU A  27
 None
None
None
None
BCR  A 201 (-3.8A)
 1.21A 3h52B-5fcyA:
undetectable		 3h52B-5fcyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5fcy RED CAROTENOID
PROTEIN (RCP)
(Nostoc
sp.
PCC
7120) 		3 / 3 PRO A 152
MET A 153
TYR A 149
 None
 0.85A 4qa2B-5fcyA:
undetectable		 4qa2B-5fcyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5fcy RED CAROTENOID
PROTEIN (RCP)
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 105
TYR A  90
MET A 153
VAL A 150
ILE A  79
 BCR  A 201 ( 3.9A)
None
None
None
None
 1.41A 5w8aA-5fcyA:
undetectable		 5w8aA-5fcyA:
20.27