SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5fd4 COMR
(Streptococcus
suis) 		5 / 12 VAL A  15
LEU A  41
SER A  37
TYR A 151
GLU A 120
 None
 1.36A 1mmkA-5fd4A:
undetectable		 1mmkA-5fd4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5fd4 COMR
(Streptococcus
suis) 		5 / 11 VAL A  15
LEU A  41
SER A  37
TYR A 151
GLU A 120
 None
 1.37A 1mmtA-5fd4A:
undetectable		 1mmtA-5fd4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5fd4 COMR
(Streptococcus
suis) 		4 / 8 TYR A 276
ASP A 302
TRP A 259
LEU A 291
 None
 1.21A 1pk2A-5fd4A:
undetectable		 1pk2A-5fd4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5fd4 COMR
(Streptococcus
suis) 		5 / 12 LEU A 211
VAL A 169
ILE A 221
LEU A 215
ILE A 234
 None
 1.13A 3ijdA-5fd4A:
undetectable		 3ijdA-5fd4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5fd4 COMR
(Streptococcus
suis) 		5 / 12 ILE A 124
SER A 131
THR A 140
SER A 217
LEU A 196
 None
 1.11A 3v8vA-5fd4A:
undetectable		 3v8vA-5fd4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5fd4 COMR
(Streptococcus
suis) 		5 / 12 ALA A  22
ARG A  14
ALA A  60
ILE A  44
LEU A  41
 None
 1.02A 4r3aB-5fd4A:
undetectable		 4r3aB-5fd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5fd4 COMR
(Streptococcus
suis) 		5 / 9 ILE A 234
PRO A 230
VAL A 169
LEU A 173
LEU A 257
 None
 1.38A 5iepA-5fd4A:
undetectable		 5iepA-5fd4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5fd4 COMR
(Streptococcus
suis) 		5 / 11 LEU A 215
THR A 214
ILE A 203
ILE A 200
ILE A 241
 None
 1.08A 6gp2B-5fd4A:
undetectable		 6gp2B-5fd4A:
13.29