SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5fds PROFILIN-2
(Hevea
brasiliensis) 		5 / 12 VAL A  94
ILE A 103
ILE A  67
PHE A  42
LEU A  60
 None
 0.96A 1qhsA-5fdsA:
undetectable		 1qhsA-5fdsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5fds PROFILIN-2
(Hevea
brasiliensis) 		5 / 12 VAL A  94
ILE A 103
ILE A  67
PHE A  42
LEU A  60
 None
 0.91A 1qhyA-5fdsA:
undetectable		 1qhyA-5fdsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5fds PROFILIN-2
(Hevea
brasiliensis) 		4 / 4 VAL A  92
THR A  93
VAL A  82
GLY A  77
 None
 1.15A 2p2fB-5fdsA:
undetectable		 2p2fB-5fdsA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fds PROFILIN-2
(Hevea
brasiliensis) 		5 / 12 ILE A  50
GLU A  46
PHE A  42
SER A  21
ILE A 103
 None
 1.20A 2xkwB-5fdsA:
undetectable		 2xkwB-5fdsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5fds PROFILIN-2
(Hevea
brasiliensis) 		5 / 9 ILE A 102
GLY A 104
ILE A 105
VAL A  32
ILE A  26
 None
 1.16A 3ekyB-5fdsA:
undetectable		 3ekyB-5fdsA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 5fds PROFILIN-2
(Hevea
brasiliensis) 		5 / 10 LEU A 101
GLU A  46
LEU A  65
PRO A  40
PHE A  39
 None
 1.49A 3ua5B-5fdsA:
undetectable		 3ua5B-5fdsA:
13.01