SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 ALA A  92
VAL A 113
TRP A 117
 None
 0.69A 1c4dA-5feiA:
undetectable
1c4dB-5feiA:
undetectable		 1c4dA-5feiA:
1.91
1c4dB-5feiA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 TRP A 117
ALA A  92
VAL A 113
 None
 0.79A 1c4dA-5feiA:
undetectable
1c4dB-5feiA:
undetectable		 1c4dA-5feiA:
1.91
1c4dB-5feiA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 ALA A  92
VAL A 113
TRP A 117
 None
 0.90A 1c4dC-5feiA:
undetectable
1c4dD-5feiA:
undetectable		 1c4dC-5feiA:
1.91
1c4dD-5feiA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 ILE A 297
PHE A 281
ILE A 302
PRO A 303
LEU A 263
 None
 0.90A 1drfA-5feiA:
undetectable		 1drfA-5feiA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 0.95A 1kglA-5feiA:
undetectable		 1kglA-5feiA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 7 ASP A 311
ASN A 354
ILE A 352
ASP A 377
 None
 0.64A 1yc5A-5feiA:
undetectable		 1yc5A-5feiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 LEU A 174
LEU A 239
ILE A 252
ILE A 408
ALA A 407
 None
 0.98A 2bxcA-5feiA:
undetectable		 2bxcA-5feiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 LEU A 174
LEU A 239
ILE A 252
ILE A 408
ALA A 407
 None
 0.94A 2bxqA-5feiA:
undetectable		 2bxqA-5feiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 PHE A 281
LEU A 365
ILE A 302
SER A 199
LEU A 274
 None
 1.08A 2lbdA-5feiA:
undetectable		 2lbdA-5feiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 6 SER A 126
ARG A 574
PHE A 577
ILE A 573
 None
 1.21A 2qeiA-5feiA:
undetectable		 2qeiA-5feiA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 ILE A 297
PHE A 281
ILE A 302
PRO A 303
LEU A 263
 None
 0.96A 2w3bA-5feiA:
undetectable		 2w3bA-5feiA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 TYR A 330
GLU A 336
ASP A 339
 None
 0.85A 3bxoB-5feiA:
undetectable		 3bxoB-5feiA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 7 TYR A 210
ASN A 194
ASP A 251
SER A 247
 None
 1.30A 3lslA-5feiA:
undetectable
3lslD-5feiA:
undetectable		 3lslA-5feiA:
17.28
3lslD-5feiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 7 SER A 247
TYR A 210
ASN A 194
ASP A 251
 None
 1.28A 3lslA-5feiA:
undetectable
3lslD-5feiA:
undetectable		 3lslA-5feiA:
17.28
3lslD-5feiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 8 ILE A  13
ILE A  78
PHE A 109
VAL A  51
 None
 0.78A 4acaC-5feiA:
2.5		 4acaC-5feiA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 8 ILE A  13
ILE A  78
PHE A 109
VAL A  51
 None
 0.77A 4acbC-5feiA:
2.7		 4acbC-5feiA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 7 LEU A 327
ASP A 322
SER A 527
TYR A 535
 None
 1.21A 4arcA-5feiA:
undetectable		 4arcA-5feiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 ILE A 297
PHE A 281
ILE A 302
PRO A 303
LEU A 263
 None
 0.93A 4m6kA-5feiA:
undetectable		 4m6kA-5feiA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		4 / 6 GLU A 110
ALA A  75
LEU A  72
TYR A  62
 None
 1.04A 5igiA-5feiA:
undetectable		 5igiA-5feiA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.15A 5ljbA-5feiA:
undetectable		 5ljbA-5feiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.15A 5ljcA-5feiA:
undetectable		 5ljcA-5feiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		5 / 12 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.13A 5ljeA-5feiA:
undetectable		 5ljeA-5feiA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 SER A 397
SER A 393
ALA A 307
 None
 0.64A 6dwnC-5feiA:
undetectable		 6dwnC-5feiA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5fei DISTAL TUBE PROTEIN
(Bacillus
virus
phi29) 		3 / 3 TYR A  91
ASP A 112
GLN A 115
 None
 0.94A 6g1pA-5feiA:
undetectable		 6g1pA-5feiA:
18.78