SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ff9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		3 / 3 ALA A 242
VAL A  42
TRP A  69
 None
 0.89A 1micA-5ff9A:
undetectable
1micB-5ff9A:
undetectable		 1micA-5ff9A:
6.67
1micB-5ff9A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 6 SER A 152
PHE A 100
ASN A 105
ILE A 106
 None
 1.01A 1yc2A-5ff9A:
4.0		 1yc2A-5ff9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 8 ASP A 126
LYS A 117
GLY A 171
TYR A 175
 None
None
None
NAP  A 301 (-4.5A)
 1.03A 2aouA-5ff9A:
7.2		 2aouA-5ff9A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 12 GLY A  32
ARG A  57
ASP A  82
SER A  84
ALA A 111
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.9A)
NAP  A 301 (-3.6A)
NAP  A 301 ( 4.2A)
NAP  A 301 ( 3.8A)
 0.78A 2br4C-5ff9A:
2.0		 2br4C-5ff9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 8 GLY A 112
GLY A 113
ILE A 174
THR A 178
 NAP  A 301 (-3.7A)
None
None
None
 0.62A 3d41A-5ff9A:
4.2		 3d41A-5ff9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 12 GLY A  32
ALA A  40
ASP A  82
VAL A  83
VAL A 133
 NAP  A 301 (-3.3A)
None
NAP  A 301 (-3.6A)
NAP  A 301 (-3.6A)
None
 1.08A 3dmfA-5ff9A:
7.1		 3dmfA-5ff9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 7 ASN A 134
TYR A 175
ASN A 183
ALA A 204
 None
NAP  A 301 (-4.5A)
SO4  A 302 (-4.3A)
None
 1.36A 3frqB-5ff9A:
undetectable		 3frqB-5ff9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 7 ILE A 235
ARG A 234
GLY A 233
VAL A 230
 None
 0.98A 4a3uB-5ff9A:
2.1		 4a3uB-5ff9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 11 ILE A  41
ILE A  37
GLY A  36
VAL A 263
GLY A 236
 None
NAP  A 301 (-4.2A)
NAP  A 301 (-3.6A)
None
None
 0.92A 4ac9B-5ff9A:
6.2
4ac9C-5ff9A:
5.8		 4ac9B-5ff9A:
19.92
4ac9C-5ff9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 12 ILE A 261
ILE A 203
VAL A 158
HIS A 159
ILE A 160
 None
None
None
None
NAP  A 301 (-4.3A)
 0.96A 4ax8A-5ff9A:
7.5		 4ax8A-5ff9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 12 ILE A  37
VAL A  42
ALA A  28
LEU A 104
GLY A 155
 NAP  A 301 (-4.2A)
None
None
None
None
 0.90A 5igtA-5ff9A:
undetectable		 5igtA-5ff9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		4 / 5 ILE A 261
ILE A 160
HIS A 159
VAL A 158
 None
NAP  A 301 (-4.3A)
None
None
 1.02A 5jmnA-5ff9A:
undetectable		 5jmnA-5ff9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE
(Narcissus
pseudonarcissus) 		5 / 12 LEU A  45
ILE A  41
LEU A 244
ILE A 203
ALA A 204
 None
 1.40A 6qxsD-5ff9A:
undetectable		 6qxsD-5ff9A:
20.77