SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ffq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		3 / 3 ALA A  85
HIS A  86
VAL A  89
 None
 0.42A 1lqtB-5ffqA:
5.1		 1lqtB-5ffqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		3 / 3 ALA A  85
HIS A  86
VAL A  89
 None
 0.40A 1lquB-5ffqA:
5.2		 1lquB-5ffqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 172
LEU A 153
GLY A 152
GLY A 151
PRO A 150
 None
PO4  A 301 (-4.8A)
None
None
None
 0.91A 1uakA-5ffqA:
undetectable		 1uakA-5ffqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  71
ILE A  98
VAL A  30
ALA A  31
PHE A  50
 None
 1.08A 1uduB-5ffqA:
undetectable		 1uduB-5ffqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  93
MET A 101
SER A  75
LEU A 103
THR A 140
 None
 1.36A 1ya3B-5ffqA:
undetectable		 1ya3B-5ffqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 148
VAL A  14
SER A 106
PRO A 150
GLY A 151
 None
PO4  A 301 (-3.9A)
None
None
None
 1.06A 2vmyA-5ffqA:
3.8		 2vmyA-5ffqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 PHE A   7
HIS A  86
ARG A 149
GLY A   8
SER A  75
 None
 1.25A 3sueD-5ffqA:
undetectable		 3sueD-5ffqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		3 / 3 SER A 112
ASP A 111
GLN A 139
 None
 0.81A 4oltA-5ffqA:
undetectable
4oltB-5ffqA:
undetectable		 4oltA-5ffqA:
24.34
4oltB-5ffqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 139
SER A 112
ASP A 111
 None
 0.78A 4qwpA-5ffqA:
undetectable
4qwpB-5ffqA:
undetectable		 4qwpA-5ffqA:
24.34
4qwpB-5ffqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		4 / 7 GLY A  11
GLY A  10
ALA A  16
ILE A  33
 None
 0.73A 4yjiA-5ffqA:
undetectable		 4yjiA-5ffqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 172
LEU A 153
GLY A 152
GLY A 151
PRO A 150
 None
PO4  A 301 (-4.8A)
None
None
None
 0.88A 5wyqB-5ffqA:
undetectable		 5wyqB-5ffqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5ffq SHUY-LIKE PROTEIN
(Escherichia
coli) 		5 / 12 PHE A   7
HIS A  86
ARG A 149
GLY A   8
SER A  75
 None
 1.12A 6c2mA-5ffqA:
undetectable		 6c2mA-5ffqA:
18.99