SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5fft	PULMONARY SURFACTANT-ASSOCIATE D PROTEIN A (Rattus norvegicus)	4 / 6	ILE A 131 THR A 130 VAL A 144 ASP A 182	None	1.12A	4iaqA-5fftA: undetectable	4iaqA-5fftA: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNJ_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	5fft	PULMONARY SURFACTANT-ASSOCIATE D PROTEIN A (Rattus norvegicus)	4 / 8	TYR A 188 TRP A 213 THR A 212 LEU A 167	None SME A 169 ( 4.1A) None SME A 169 ( 3.7A)	1.13A	6cnjD-5fftA: undetectable 6cnjE-5fftA: undetectable	6cnjD-5fftA: 16.67 6cnjE-5fftA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GH9_A_MIXA1003_0 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15)	5fft	PULMONARY SURFACTANT-ASSOCIATE D PROTEIN A (Rattus norvegicus)	4 / 5	ASN A 151 TYR A 192 GLY A 194 ASP A 210	None	1.28A	6gh9A-5fftA: undetectable	6gh9A-5fftA: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_B_LLLB301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5fft	PULMONARY SURFACTANT-ASSOCIATE D PROTEIN A (Rattus norvegicus)	4 / 7	TYR A 208 GLU A 195 ASP A 215 GLU A 171	None CA A 300 (-2.8A) CA A 300 (-3.1A) None	1.20A	6mn5B-5fftA: undetectable	6mn5B-5fftA: 17.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4IAQ_A_2GMA2001_2","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","5fft","PULMONARY SURFACTANT-ASSOCIATED PROTEIN A","Rattus norvegicus",4,"ILE A 131;THR A 130;VAL A 144;ASP A 182","None","1.12A","4iaqA-5fftA:undetectable","4iaqA-5fftA:16.50"],["6CNJ_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","5fft","PULMONARY SURFACTANT-ASSOCIATED PROTEIN A","Rattus norvegicus",4,"TYR A 188;TRP A 213;THR A 212;LEU A 167","None;SME A 169 ( 4.1A);None;SME A 169 ( 3.7A)","1.13A","6cnjD-5fftA:undetectable;6cnjE-5fftA:undetectable","6cnjD-5fftA:16.67;6cnjE-5fftA:23.20"],["6GH9_A_MIXA1003_0","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","5fft","PULMONARY SURFACTANT-ASSOCIATED PROTEIN A","Rattus norvegicus",4,"ASN A 151;TYR A 192;GLY A 194;ASP A 210","None","1.28A","6gh9A-5fftA:undetectable","6gh9A-5fftA:19.87"],["6MN5_B_LLLB301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","5fft","PULMONARY SURFACTANT-ASSOCIATED PROTEIN A","Rattus norvegicus",4,"TYR A 208;GLU A 195;ASP A 215;GLU A 171","None; CA A 300 (-2.8A); CA A 300 (-3.1A);None","1.20A","6mn5B-5fftA:undetectable","6mn5B-5fftA:17.24"]]