SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ffx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5ffx MARR FAMILY
REGULATORY PROTEIN
(Staphylococcus
aureus) 		4 / 5 LEU A  37
LEU A  40
ILE A  77
ARG A  79
 None
None
None
SO4  A 202 ( 3.9A)
 0.86A 2qd4A-5ffxA:
undetectable		 2qd4A-5ffxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ffx MARR FAMILY
REGULATORY PROTEIN
(Staphylococcus
aureus) 		5 / 9 PHE A 104
ILE A  29
GLY A  97
THR A  94
LEU A  68
 None
 1.25A 4ze0A-5ffxA:
undetectable		 4ze0A-5ffxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ffx MARR FAMILY
REGULATORY PROTEIN
(Staphylococcus
aureus) 		4 / 4 ILE A  77
ILE A  91
ARG A  79
LEU A  37
 None
None
SO4  A 202 ( 3.9A)
None
 1.40A 5dzkh-5ffxA:
undetectable
5dzkn-5ffxA:
undetectable
5dzkv-5ffxA:
undetectable		 5dzkh-5ffxA:
19.70
5dzkn-5ffxA:
19.70
5dzkv-5ffxA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5ffx MARR FAMILY
REGULATORY PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A  68
LEU A  71
SER A  96
LEU A 100
LEU A  93
 None
 1.06A 5mwyA-5ffxA:
undetectable		 5mwyA-5ffxA:
22.92