SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 216
LEU A 217
ALA A 260
LEU A 249
 None
 0.87A 1pthA-5fg0A:
undetectable		 1pthA-5fg0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 216
LEU A 217
ALA A 260
LEU A 249
 None
 0.87A 1pthB-5fg0A:
undetectable		 1pthB-5fg0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 361
LEU A 314
LEU A 295
LYS A 338
LEU A 317
 None
 1.12A 2ceoA-5fg0A:
undetectable		 2ceoA-5fg0A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 251
LEU A 249
HIS A 209
 None
 0.86A 2q6fB-5fg0A:
undetectable		 2q6fB-5fg0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 361
LEU A 314
LEU A 295
LYS A 338
LEU A 317
 None
 1.19A 2riwA-5fg0A:
undetectable
2riwB-5fg0A:
undetectable		 2riwA-5fg0A:
24.25
2riwB-5fg0A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 11 THR A 348
ILE A 298
LEU A 304
LEU A 310
THR A 258
 None
 1.34A 3a50B-5fg0A:
undetectable		 3a50B-5fg0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 113
LEU A  47
SER A  92
LEU A 121
ILE A  73
 None
 1.09A 3cd2A-5fg0A:
undetectable		 3cd2A-5fg0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 139
THR A 140
LEU A 137
GLU A 142
 EDO  A 502 ( 3.9A)
None
None
EDO  A 502 (-3.9A)
 0.99A 3ps9A-5fg0A:
undetectable		 3ps9A-5fg0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 132
PHE A  51
ILE A  94
LEU A 117
PHE A  87
 None
 1.13A 3t3rA-5fg0A:
undetectable		 3t3rA-5fg0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  15
ASP A  31
ASP A 243
ASN A  28
 None
None
K  A 501 ( 4.7A)
None
 1.05A 4feuD-5fg0A:
1.5		 4feuD-5fg0A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  72
PHE A  87
ILE A  73
 None
 0.65A 5dzk1-5fg0A:
undetectable
5dzkF-5fg0A:
undetectable
5dzkM-5fg0A:
undetectable		 5dzk1-5fg0A:
33.33
5dzkF-5fg0A:
17.15
5dzkM-5fg0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  46
LEU A 121
SER A  44
PHE A  87
LEU A  69
 None
 1.37A 5nd2B-5fg0A:
undetectable		 5nd2B-5fg0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 106
GLN A 109
GLU A 154
SER A 151
 None
 0.83A 6c06C-5fg0A:
undetectable		 6c06C-5fg0A:
undetectable