SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 7 VAL A  58
GLY A  82
THR A 227
ILE A  63
None
0.82A 1gtnC-5fg3A:
undetectable
1gtnD-5fg3A:
undetectable
1gtnC-5fg3A:
8.60
1gtnD-5fg3A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ILE A 550
GLY A 496
VAL A 486
ALA A 538
GLY A 557
None
1.07A 1kiaA-5fg3A:
undetectable
1kiaA-5fg3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ILE A 550
GLY A 496
VAL A 486
ALA A 538
GLY A 557
None
1.06A 1kiaB-5fg3A:
undetectable
1kiaB-5fg3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ILE A 550
GLY A 496
VAL A 486
ALA A 538
GLY A 557
None
1.06A 1kiaC-5fg3A:
undetectable
1kiaC-5fg3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
3 / 3 ARG A 475
ARG A 466
ARG A 535
None
1.01A 1l7fA-5fg3A:
undetectable
1l7fA-5fg3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
3 / 3 ARG A 475
ARG A 466
ARG A 535
None
0.99A 1l7hA-5fg3A:
undetectable
1l7hA-5fg3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 11 GLU A 377
ARG A 132
ARG A  98
LEU A 357
GLU A 353
None
1.16A 1mjlA-5fg3A:
undetectable
1mjlB-5fg3A:
undetectable
1mjlA-5fg3A:
9.97
1mjlB-5fg3A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ILE A 550
GLY A 496
VAL A 486
ALA A 538
GLY A 557
None
1.07A 1nbhB-5fg3A:
2.1
1nbhB-5fg3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ILE A 550
GLY A 496
VAL A 486
ALA A 538
GLY A 557
None
1.15A 1nbiB-5fg3A:
undetectable
1nbiB-5fg3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ALA A 534
GLY A 502
ILE A 504
LEU A 585
ILE A 572
None
1.09A 1x1aA-5fg3A:
2.0
1x1aA-5fg3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 LEU A 536
GLY A 501
VAL A 497
THR A 562
ILE A 591
None
1.40A 1z95A-5fg3A:
undetectable
1z95A-5fg3A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 VAL A 366
LEU A 416
LEU A 420
GLY A 387
LEU A 383
None
1.09A 2aylA-5fg3A:
undetectable
2aylA-5fg3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
None
0.93A 3el5B-5fg3A:
undetectable
3el5B-5fg3A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
None
0.92A 3gguA-5fg3A:
undetectable
3gguA-5fg3A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 8 ARG A 279
SER A 401
GLY A 396
PRO A 397
None
0.91A 3hcrA-5fg3A:
2.1
3hcrA-5fg3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
None
0.91A 3hj3C-5fg3A:
undetectable
3hj3C-5fg3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 8 VAL A 318
MET A 292
TYR A 313
ILE A 263
None
0.95A 3remA-5fg3A:
undetectable
3remA-5fg3A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 8 VAL A 318
MET A 292
TYR A 313
ILE A 263
None
0.94A 3remB-5fg3A:
undetectable
3remB-5fg3A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 6 LEU A 128
GLU A 124
SER A  95
THR A 375
None
1.48A 3ropA-5fg3A:
4.3
3ropA-5fg3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 9 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
None
0.85A 3u7sA-5fg3A:
undetectable
3u7sA-5fg3A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 9 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
None
0.87A 3u7sB-5fg3A:
undetectable
3u7sB-5fg3A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 TYR A 335
ILE A 320
GLU A 353
TYR A 264
VAL A 318
None
1.08A 4a97A-5fg3A:
undetectable
4a97B-5fg3A:
undetectable
4a97A-5fg3A:
18.94
4a97B-5fg3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 VAL A 366
ALA A 406
LEU A 450
VAL A 368
THR A 409
None
1.47A 4kyaB-5fg3A:
undetectable
4kyaB-5fg3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 VAL A 366
ALA A 406
LEU A 450
VAL A 368
THR A 409
None
1.47A 4kyaH-5fg3A:
undetectable
4kyaH-5fg3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 VAL A  58
ILE A 216
LEU A  70
VAL A  76
LEU A 223
None
1.26A 4m11D-5fg3A:
undetectable
4m11D-5fg3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 LEU A 536
GLY A 501
VAL A 497
THR A 562
ILE A 591
None
1.40A 4okbA-5fg3A:
undetectable
4okbA-5fg3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 9 ILE A  74
LEU A 231
VAL A  79
LEU A  78
ILE A  80
None
1.27A 4r38C-5fg3A:
undetectable
4r38C-5fg3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 LEU A 129
ALA A 108
VAL A  20
GLY A  23
GLY A  90
None
1.00A 4rn6B-5fg3A:
undetectable
4rn6B-5fg3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 9 ALA A 139
ASP A 113
GLY A  28
LEU A  32
LEU A 219
None
None
GDP  A 701 (-3.3A)
None
None
1.20A 5dqfA-5fg3A:
undetectable
5dqfA-5fg3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 4 VAL A 259
ALA A 322
ILE A 283
THR A 285
None
1.07A 5e4dB-5fg3A:
undetectable
5e4dB-5fg3A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 10 GLY A 225
THR A 227
LEU A  78
LEU A 220
LEU A  83
None
1.29A 5fhzC-5fg3A:
undetectable
5fhzC-5fg3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
3 / 3 VAL A 104
GLU A 381
GLU A 377
None
0.69A 5jsdB-5fg3A:
undetectable
5jsdC-5fg3A:
undetectable
5jsdB-5fg3A:
20.79
5jsdC-5fg3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 7 HIS A  52
ILE A 263
VAL A 262
GLN A  16
None
1.13A 5kkzC-5fg3A:
undetectable
5kkzE-5fg3A:
undetectable
5kkzC-5fg3A:
16.61
5kkzE-5fg3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 7 HIS A  52
ILE A 263
VAL A 262
GLN A  16
None
1.08A 5kkzK-5fg3A:
undetectable
5kkzQ-5fg3A:
undetectable
5kkzK-5fg3A:
21.30
5kkzQ-5fg3A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 7 GLY A 317
ALA A 316
GLY A 244
ILE A 334
None
0.66A 5kqyB-5fg3A:
undetectable
5kqyB-5fg3A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 GLY A 278
VAL A 276
GLY A 331
VAL A 350
ALA A 330
None
1.17A 5x7fA-5fg3A:
undetectable
5x7fA-5fg3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
5 / 12 LEU A 110
PHE A 118
ILE A 171
LEU A 172
ILE A 179
None
1.17A 5y2tB-5fg3A:
undetectable
5y2tB-5fg3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix)
4 / 7 VAL A 262
LEU A  97
LEU A  93
LEU A  84
None
0.64A 6g9bA-5fg3A:
undetectable
6g9bB-5fg3A:
undetectable
6g9bA-5fg3A:
8.75
6g9bB-5fg3A:
10.07