SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		6 / 12 TYR B  35
GLN B  88
PHE B  98
VAL E  37
ALA E  97
TRP E 117
 None
 0.80A 1h8sA-5fgcB:
17.7		 1h8sA-5fgcB:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU B 135
THR B 172
SER B 162
THR B 164
 None
 0.75A 1ictD-5fgcB:
undetectable		 1ictD-5fgcB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU B 179
GLY B 128
PRO B 120
VAL B 132
 None
 0.88A 2aojA-5fgcB:
undetectable		 2aojA-5fgcB:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  35
PRO B  43
TYR B  86
TYR E  95
 None
 0.64A 2oldA-5fgcB:
16.1
2oldB-5fgcB:
21.3		 2oldA-5fgcB:
48.43
2oldB-5fgcB:
48.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR E  95
TYR B  35
PRO B  43
TYR B  86
 None
 0.69A 2oldA-5fgcE:
18.6
2oldB-5fgcE:
15.1		 2oldA-5fgcE:
29.08
2oldB-5fgcE:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TRP B  90
PHE E 114
TYR E 113
VAL E 101
 None
 1.40A 2zbuB-5fgcB:
undetectable		 2zbuB-5fgcB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 ILE B  57
ARG B  75
THR B  73
LEU B  72
 None
 0.94A 3ag1N-5fgcB:
undetectable
3ag1W-5fgcB:
undetectable		 3ag1N-5fgcB:
16.80
3ag1W-5fgcB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 PHE E 136
GLY E 132
THR E 219
VAL E 212
VAL E 221
 None
 1.22A 4jx1B-5fgcE:
undetectable		 4jx1B-5fgcE:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		3 / 3 ASP B  91
TYR B   2
TRP B  90
 None
 1.33A 4p7nA-5fgcB:
undetectable		 4p7nA-5fgcB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		3 / 3 ASP B  50
LEU B  27
GLY B  28
 None
 0.58A 4xmfA-5fgcB:
undetectable		 4xmfA-5fgcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA E  92
THR E  91
VAL E 123
GLU E  89
 None
 0.75A 5ecmD-5fgcE:
undetectable		 5ecmD-5fgcE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA E  92
THR E  91
VAL E 123
GLU E  89
 None
 0.81A 5ecoD-5fgcE:
undetectable		 5ecoD-5fgcE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ILE B  57
ARG B  75
THR B  73
LEU B  72
 None
 0.93A 5iy5N-5fgcB:
undetectable
5iy5W-5fgcB:
undetectable		 5iy5N-5fgcB:
16.80
5iy5W-5fgcB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		3 / 3 VAL B  47
SER B  33
TRP B  34
 None
 0.89A 5jwaA-5fgcB:
undetectable		 5jwaA-5fgcB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens) 		3 / 3 LYS B 169
ASP B 167
ARG B  38
 None
 0.92A 5jwaA-5fgcB:
undetectable
5jwaH-5fgcB:
undetectable		 5jwaA-5fgcB:
17.02
5jwaH-5fgcB:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER E 126
ALA E 128
PHE E 160
LEU E 184
 None
 0.39A 5mthA-5fgcE:
26.7		 5mthA-5fgcE:
53.68