SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PHG_A_MYTA422_1 (CYTOCHROME P450-CAM)	5fgl	NICR (Pseudomonas putida)	5 / 11	THR A 107 VAL A 177 GLY A 180 ILE A 110 VAL A 111	None	1.06A	1phgA-5fglA: undetectable	1phgA-5fglA: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 10	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.08A	1pxxA-5fglA: undetectable	1pxxA-5fglA: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_B_DIFB1701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 9	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.09A	1pxxB-5fglA: 2.0	1pxxB-5fglA: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_C_DIFC2701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 12	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.08A	1pxxC-5fglA: undetectable	1pxxC-5fglA: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_D_DIFD3701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 10	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.08A	1pxxD-5fglA: 2.0	1pxxD-5fglA: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_2 (PHOSPHOLIPASE A2)	5fgl	NICR (Pseudomonas putida)	4 / 8	TYR A 94 ASN A 93 LYS A 90 LYS A 89	None	1.36A	3bjwD-5fglA: undetectable	3bjwD-5fglA: 16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRX_A_LURA706_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 12	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.01A	4rrxA-5fglA: undetectable	4rrxA-5fglA: 16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRX_B_LURB706_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5fgl	NICR (Pseudomonas putida)	5 / 12	VAL A 111 LEU A 229 VAL A 177 GLY A 180 ALA A 181	None	1.01A	4rrxB-5fglA: undetectable	4rrxB-5fglA: 16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_A_IMNA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5fgl	NICR (Pseudomonas putida)	5 / 12	PHE A 76 LEU A 138 LEU A 149 LEU A 153 TYR A 154	None None None None 6HY A 301 (-3.4A)	1.23A	4xumA-5fglA: 2.3	4xumA-5fglA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YO9_B_ACTB401_0 (3C-LIKE PROTEINASE)	5fgl	NICR (Pseudomonas putida)	3 / 3	ARG A 91 ASP A 88 TYR A 154	6HY A 301 (-3.3A) None 6HY A 301 (-3.4A)	0.86A	4yo9B-5fglA: undetectable	4yo9B-5fglA: 19.87

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PHG_A_MYTA422_1","CYTOCHROME P450-CAM","5fgl","NICR","Pseudomonas putida",5,"THR A 107;VAL A 177;GLY A 180;ILE A 110;VAL A 111","None","1.06A","1phgA-5fglA:undetectable","1phgA-5fglA:20.33"],["1PXX_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.08A","1pxxA-5fglA:undetectable","1pxxA-5fglA:15.92"],["1PXX_B_DIFB1701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.09A","1pxxB-5fglA:2.0","1pxxB-5fglA:15.92"],["1PXX_C_DIFC2701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.08A","1pxxC-5fglA:undetectable","1pxxC-5fglA:15.92"],["1PXX_D_DIFD3701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.08A","1pxxD-5fglA:2.0","1pxxD-5fglA:15.92"],["3BJW_F_SVRF509_2","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","5fgl","NICR","Pseudomonas putida",4,"TYR A  94;ASN A  93;LYS A  90;LYS A  89","None","1.36A","3bjwD-5fglA:undetectable","3bjwD-5fglA:16.75"],["4RRX_A_LURA706_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.01A","4rrxA-5fglA:undetectable","4rrxA-5fglA:16.17"],["4RRX_B_LURB706_1","PROSTAGLANDIN G\/H SYNTHASE 2","5fgl","NICR","Pseudomonas putida",5,"VAL A 111;LEU A 229;VAL A 177;GLY A 180;ALA A 181","None","1.01A","4rrxB-5fglA:undetectable","4rrxB-5fglA:16.17"],["4XUM_A_IMNA501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","5fgl","NICR","Pseudomonas putida",5,"PHE A  76;LEU A 138;LEU A 149;LEU A 153;TYR A 154","None;None;None;None;6HY A 301 (-3.4A)","1.23A","4xumA-5fglA:2.3","4xumA-5fglA:21.60"],["4YO9_B_ACTB401_0","3C-LIKE PROTEINASE","5fgl","NICR","Pseudomonas putida",3,"ARG A  91;ASP A  88;TYR A 154","6HY A 301 (-3.3A);None;6HY A 301 (-3.4A)","0.86A","4yo9B-5fglA:undetectable","4yo9B-5fglA:19.87"]]