SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 9 LEU A 259
LEU A 249
GLU A 266
VAL A 423
GLN A 255
 None
 1.43A 1gx8A-5fgnA:
undetectable		 1gx8A-5fgnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		3 / 3 ASP A  47
HIS A  39
ASP A 176
 None
 0.89A 1nw5A-5fgnA:
undetectable		 1nw5A-5fgnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 5 VAL A 132
GLY A 131
VAL A 128
TRP A 126
 None
 0.86A 1tkqB-5fgnA:
undetectable		 1tkqB-5fgnA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 7 ILE A 169
ILE A  16
ILE A  78
PHE A  58
 None
 0.84A 1uwjA-5fgnA:
undetectable		 1uwjA-5fgnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 1v7zA-5fgnA:
undetectable		 1v7zA-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.45A 1v7zB-5fgnA:
undetectable		 1v7zB-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 1v7zC-5fgnA:
undetectable		 1v7zC-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.45A 1v7zF-5fgnA:
undetectable		 1v7zF-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 4 HIS A 378
ASP A 338
ASN A 343
ASP A 324
 None
 1.11A 1wg8A-5fgnA:
1.4		 1wg8A-5fgnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 4 GLY A 277
SER A 283
ILE A 479
HIS A 511
 None
 1.09A 1yajJ-5fgnA:
undetectable		 1yajJ-5fgnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 6 VAL A 482
MET A 483
ILE A 536
MET A 522
 None
 1.15A 2hyyC-5fgnA:
undetectable		 2hyyC-5fgnA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 3a6jA-5fgnA:
undetectable		 3a6jA-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 7 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.47A 3a6jB-5fgnA:
undetectable		 3a6jB-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.47A 3a6jF-5fgnA:
undetectable		 3a6jF-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		3 / 3 GLU A 240
HIS A 378
THR A 280
 ZN  A 603 (-1.8A)
None
ZN  A 603 ( 2.7A)
 0.82A 3hkuA-5fgnA:
undetectable		 3hkuA-5fgnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 10 ASP A 324
HIS A 378
TYR A 387
ILE A 380
GLY A 381
 None
 1.42A 3myuA-5fgnA:
1.2		 3myuA-5fgnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 8 SER A 325
ASP A 452
GLU A 352
GLU A 389
 LMT  A 602 (-3.3A)
ZN  A 603 (-2.3A)
None
None
 1.06A 3sg9B-5fgnA:
undetectable		 3sg9B-5fgnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 9 GLY A 520
ASP A 372
GLY A 493
ILE A 495
VAL A 234
 None
 0.97A 3u7sB-5fgnA:
undetectable		 3u7sB-5fgnA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 11 HIS A 378
ILE A 376
ASP A 309
PHE A 288
VAL A 334
 None
 1.36A 4fogC-5fgnA:
undetectable		 4fogC-5fgnA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		3 / 3 ASP A 372
ARG A 232
ASP A 370
 None
 0.84A 4fp9C-5fgnA:
undetectable		 4fp9C-5fgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		3 / 3 ASP A 372
ARG A 232
ASP A 370
 None
 0.87A 4fp9F-5fgnA:
undetectable		 4fp9F-5fgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 12 SER A 325
SER A 102
GLU A 298
GLU A 322
GLY A 329
 LMT  A 602 (-3.3A)
None
None
None
None
 1.46A 4zjlA-5fgnA:
undetectable		 4zjlA-5fgnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 4 TYR A 387
GLY A 475
SER A 456
LEU A 457
 None
 1.33A 5bphC-5fgnA:
undetectable		 5bphC-5fgnA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 6 THR A 411
ALA A 413
THR A 414
VAL A 416
 None
 1.02A 5ecoA-5fgnA:
undetectable		 5ecoA-5fgnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 10 HIS A 378
ASN A 323
ILE A 430
ILE A 434
LEU A 437
 None
 1.43A 5vkqA-5fgnA:
5.1
5vkqB-5fgnA:
5.1		 5vkqA-5fgnA:
14.73
5vkqB-5fgnA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 8 GLN A 223
GLY A 315
GLU A 317
GLN A 216
 None
 1.06A 5vlmD-5fgnA:
undetectable		 5vlmD-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 8 ILE A  84
GLN A  91
TYR A 123
VAL A 107
 LMT  A 602 (-3.9A)
LMT  A 602 (-2.8A)
None
LMT  A 602 ( 4.8A)
 1.08A 5vlmF-5fgnA:
undetectable		 5vlmF-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 12 ASN A 356
SER A 382
ASN A 323
HIS A 378
LEU A 377
 None
 1.28A 6chgC-5fgnA:
undetectable		 6chgC-5fgnA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 12 ILE A 376
ASN A 336
LEU A 284
PHE A 288
ASN A 306
 None
 1.29A 6r2eA-5fgnA:
undetectable		 6r2eA-5fgnA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 11 ILE A 376
ASN A 336
LEU A 284
PHE A 288
ASN A 306
 None
 1.32A 6r2eG-5fgnA:
undetectable		 6r2eG-5fgnA:
18.76