SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fgu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		3 / 3 LEU A1263
HIS A1239
ILE A1111
 None
 0.54A 1s9pB-5fguA:
undetectable		 1s9pB-5fguA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		4 / 6 LEU A1189
GLY A1188
ASN A1211
ILE A1204
 None
SO4  A1403 (-3.7A)
SO4  A1403 (-3.2A)
None
 0.77A 1xf1B-5fguA:
undetectable		 1xf1B-5fguA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.80A 2q6fB-5fguA:
undetectable		 2q6fB-5fguA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		3 / 3 LEU A1173
ASN A1215
ARG A1179
 None
SO4  A1401 (-3.9A)
SO4  A1401 (-4.0A)
 0.84A 2qhfA-5fguA:
undetectable		 2qhfA-5fguA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 5 ASP A 180
ARG A 168
ILE A 167
VAL A 150
 None
 1.25A 3eigA-5fguA:
undetectable		 3eigA-5fguA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		4 / 7 VAL A 224
ILE A 152
VAL A 163
GLN A  94
 None
None
None
CR2  A  66 ( 3.3A)
 0.86A 3fi0E-5fguA:
undetectable		 3fi0E-5fguA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 12 TYR A1096
GLY A1188
ALA A1191
ILE A1112
ILE A1111
 None
SO4  A1403 (-3.7A)
SO4  A1403 (-3.9A)
None
None
 0.99A 3ld6A-5fguA:
undetectable		 3ld6A-5fguA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.15A 3t3rB-5fguA:
undetectable		 3t3rB-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rC-5fguA:
undetectable		 3t3rC-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.14A 3t3rD-5fguA:
undetectable		 3t3rD-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 6 LYS A  68
LEU A  42
ALA A  72
THR A 225
 CR2  A  66 ( 3.5A)
None
None
None
 1.02A 4ikiB-5fguA:
undetectable		 4ikiB-5fguA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		5 / 12 GLY A1103
GLY A1101
ILE A1204
GLY A1106
LEU A1189
 None
 1.16A 4n48B-5fguA:
undetectable		 4n48B-5fguA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 (-4.8A)
 0.95A 4o1zA-5fguA:
undetectable		 4o1zA-5fguA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 7 GLU A1150
ARG A1200
TYR A1139
TYR A1137
 None
 1.19A 4zz8A-5fguA:
undetectable		 4zz8A-5fguA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		3 / 3 LEU A 201
ILE A 152
TYR A  92
 None
 0.67A 5uunB-5fguA:
undetectable		 5uunB-5fguA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 6 TYR A 143
LEU A 221
GLU A1373
LEU A1337
 None
 1.46A 5xooA-5fguA:
undetectable		 5xooA-5fguA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 5 GLY A1135
ARG A1104
GLN A1210
MET A1221
 None
 1.12A 5zrfB-5fguA:
undetectable		 5zrfB-5fguA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 7 PHE A 165
SER A 202
VAL A 224
ARG A  96
 CR2  A  66 (-4.8A)
None
None
CR2  A  66 ( 3.1A)
 1.42A 6av6C-5fguA:
undetectable
6av6D-5fguA:
undetectable		 6av6C-5fguA:
9.40
6av6D-5fguA:
9.40