SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 GLY A 195
GLY A 196
ALA A 108
LEU A 189
PHE A 199
 None
 1.02A 1bx4A-5fgwA:
undetectable		 1bx4A-5fgwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		3 / 3 LEU A 263
HIS A 239
ILE A 111
 None
ZN  A 308 (-3.2A)
None
 0.57A 1s9pB-5fgwA:
undetectable		 1s9pB-5fgwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		4 / 6 LEU A 189
GLY A 188
ASN A 211
ILE A 204
 None
ZN  A 302 ( 4.5A)
ZN  A 302 (-2.8A)
None
 0.87A 1xf1B-5fgwA:
undetectable		 1xf1B-5fgwA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 THR A 205
ASP A 100
ARG A 147
GLY A 290
TYR A 139
 None
 1.38A 1xvaA-5fgwA:
undetectable		 1xvaA-5fgwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		4 / 7 SER A  97
LEU A 189
THR A 245
PRO A 246
 None
 0.98A 2ddwB-5fgwA:
undetectable		 2ddwB-5fgwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 SER A  92
PHE A  68
THR A 113
LEU A 194
ILE A 190
 None
 1.45A 2xrlA-5fgwA:
undetectable		 2xrlA-5fgwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 TYR A  96
GLY A 188
ALA A 191
ILE A 112
ILE A 111
 None
ZN  A 302 ( 4.5A)
None
None
None
 1.01A 3ld6A-5fgwA:
undetectable		 3ld6A-5fgwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 GLY A 103
GLY A 101
ILE A 204
GLY A 106
LEU A 189
 None
 1.15A 4n48A-5fgwA:
undetectable		 4n48A-5fgwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		5 / 12 GLY A 103
GLY A 101
ILE A 204
GLY A 106
LEU A 189
 None
 1.16A 4n48B-5fgwA:
undetectable		 4n48B-5fgwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		4 / 4 LEU A  99
TYR A 109
PRO A 246
ILE A 204
 None
 1.33A 5esgA-5fgwA:
undetectable		 5esgA-5fgwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5fgw EXTRACELLULAR
STREPTODORNASE D
(Streptococcus
pyogenes) 		4 / 5 GLY A 135
ARG A 104
GLN A 210
MET A 221
 None
 1.20A 5zrfB-5fgwA:
undetectable		 5zrfB-5fgwA:
15.73