SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5fhc ANTIBODY 100 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO A 213
GLY A 190
TYR A 194
 None
 0.65A 2vouA-5fhcA:
undetectable		 2vouA-5fhcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5fhc ANTIBODY 100 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO A 213
GLY A 190
TYR A 194
 None
 0.60A 2vouB-5fhcA:
undetectable		 2vouB-5fhcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5fhc ANTIBODY 100 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO A 213
GLY A 190
TYR A 194
 None
 0.60A 2vouC-5fhcA:
undetectable		 2vouC-5fhcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5fhc ANTIBODY 114 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 GLU H  46
ASP H  42
ASP H  86
 None
 0.76A 3jb2A-5fhcH:
undetectable		 3jb2A-5fhcH:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5fhc ANTIBODY 114 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H   2
ALA H  24
MET H  34
ARG H  71
ASN H  73
 None
 0.81A 3qxvC-5fhcH:
20.4		 3qxvC-5fhcH:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5fhc ANTIBODY 100 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA A  95
SER A  35
ILE A  78
LEU A   4
 None
 1.06A 4uymA-5fhcA:
undetectable		 4uymA-5fhcA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5fhc ENVELOPE
GLYCOPROTEIN
(Zaire
ebolavirus) 		4 / 7 LEU J 515
TYR J 517
MET J 548
LEU J 558
 None
 0.81A 5jq7B-5fhcJ:
9.4		 5jq7B-5fhcJ:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5fhc ENVELOPE
GLYCOPROTEIN
(Zaire
ebolavirus) 		5 / 7 LEU J 515
TYR J 517
THR J 519
THR J 520
LEU J 558
 None
 0.50A 5jq7B-5fhcJ:
9.4		 5jq7B-5fhcJ:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5fhc ENVELOPE
GLYCOPROTEIN
(Zaire
ebolavirus) 		5 / 10 LEU J 515
TYR J 517
THR J 519
MET J 548
LEU J 558
 None
 0.70A 6f5uA-5fhcJ:
undetectable
6f5uB-5fhcJ:
9.5		 6f5uA-5fhcJ:
18.63
6f5uB-5fhcJ:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5fhc ENVELOPE
GLYCOPROTEIN
(Zaire
ebolavirus) 		5 / 12 LEU J 515
TYR J 517
THR J 519
MET J 548
LEU J 558
 None
 0.37A 6f6iA-5fhcJ:
undetectable
6f6iB-5fhcJ:
9.5		 6f6iA-5fhcJ:
18.63
6f6iB-5fhcJ:
100.00