SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		5 / 10 LEU A 391
ALA A 585
VAL A 394
LEU A 407
ASP A 384
 None
 1.34A 1rlbE-5fhhA:
undetectable		 1rlbE-5fhhA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 7 GLY A 342
GLN A 346
ASP A 306
ILE A 305
 ALF  A 702 ( 4.7A)
ALF  A 702 (-2.2A)
ALF  A 702 ( 4.0A)
None
 0.73A 3fi0P-5fhhA:
undetectable		 3fi0P-5fhhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 8 GLY A 342
GLN A 346
ASP A 306
ILE A 305
 ALF  A 702 ( 4.7A)
ALF  A 702 (-2.2A)
ALF  A 702 ( 4.0A)
None
 0.72A 3fi0Q-5fhhA:
undetectable		 3fi0Q-5fhhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 6 VAL A 251
ILE A 336
TRP A 297
LEU A 319
 None
 1.00A 4l1wB-5fhhA:
undetectable		 4l1wB-5fhhA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 6 ILE A 339
ILE A 263
SER A 235
PHE A 226
 None
None
ADP  A 701 ( 2.6A)
None
 0.90A 4m51A-5fhhA:
undetectable		 4m51A-5fhhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		3 / 3 ARG A 327
TRP A 297
ILE A 336
 None
 1.11A 4mwxA-5fhhA:
undetectable		 4mwxA-5fhhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 7 ILE A 224
PHE A 226
VAL A 218
ILE A 241
 None
 0.93A 4zzbC-5fhhA:
undetectable
4zzbD-5fhhA:
undetectable		 4zzbC-5fhhA:
19.46
4zzbD-5fhhA:
19.46