SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		7 / 12 TYR L  40
GLN L  93
PHE L 102
ASN H 159
VAL H 161
ALA H 220
TRP H 232
 None
 0.59A 1h8sA-5fhxL:
21.5		 1h8sA-5fhxL:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
INTERLEUKIN-4
(Homo
sapiens) 		5 / 12 GLY H  56
MET H  50
SER H  54
ASP H  55
HIS A  74
 None
None
PO4  H 401 ( 4.2A)
None
None
 1.07A 1jdvE-5fhxH:
undetectable
1jdvF-5fhxH:
undetectable		 1jdvE-5fhxH:
22.19
1jdvF-5fhxH:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5fhx INTERLEUKIN-4
(Homo
sapiens) 		4 / 6 THR A  50
LEU A  86
ASP A  87
TRP A  91
 None
 1.26A 1mxdA-5fhxA:
undetectable		 1mxdA-5fhxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens) 		4 / 5 SER H 237
LEU H 135
GLY H 134
ARG H 243
 None
 1.22A 2j2pA-5fhxH:
undetectable
2j2pB-5fhxH:
undetectable		 2j2pA-5fhxH:
22.69
2j2pB-5fhxH:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
INTERLEUKIN-4
(Homo
sapiens) 		4 / 7 LYS A  77
ASP H  52
TRP H  33
PHE A  73
 PO4  H 401 ( 4.9A)
PO4  H 401 (-3.2A)
PO4  H 401 (-4.7A)
None
 1.47A 2pk4A-5fhxA:
undetectable		 2pk4A-5fhxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU H  70
PRO L 162
GLY H  49
LEU H  60
PHE H  64
 None
 1.12A 3e23A-5fhxH:
undetectable		 3e23A-5fhxH:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN H 159
MET L  37
PHE L 102
 None
 1.12A 3g4lD-5fhxH:
undetectable		 3g4lD-5fhxH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS L 306
ARG L 334
LYS H 345
 None
 0.84A 3okxA-5fhxL:
undetectable		 3okxA-5fhxL:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.95A 3p50A-5fhxL:
undetectable		 3p50A-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.94A 3p50B-5fhxL:
undetectable		 3p50B-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.95A 3p50C-5fhxL:
undetectable		 3p50C-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.95A 3p50D-5fhxL:
3.1		 3p50D-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.93A 3p50E-5fhxL:
undetectable		 3p50E-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5fhx INTERLEUKIN-4
(Homo
sapiens) 		5 / 12 LEU A  52
LEU A 116
MET A 120
ALA A  94
ILE A  10
 None
 1.10A 3ut5D-5fhxA:
undetectable		 3ut5D-5fhxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLN H  65
ASP L  86
GLN L  83
 None
 0.93A 4aztA-5fhxH:
undetectable		 4aztA-5fhxH:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens) 		4 / 8 SER H 192
ILE H 193
TRP H 160
GLU H 205
 None
 0.96A 4cx7C-5fhxH:
undetectable
4cx7D-5fhxH:
undetectable		 4cx7C-5fhxH:
20.73
4cx7D-5fhxH:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens) 		4 / 5 TYR H 217
LEU H 204
LEU H 209
ARG H 190
 None
 1.28A 4em2A-5fhxH:
undetectable		 4em2A-5fhxH:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens) 		4 / 8 SER H 259
LEU H 255
ALA H 268
SER H 258
 None
 1.00A 4iklA-5fhxH:
4.0
4iklB-5fhxH:
undetectable		 4iklA-5fhxH:
15.77
4iklB-5fhxH:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fhx INTERLEUKIN-4
(Homo
sapiens) 		4 / 6 THR A  39
GLU A  43
THR A  44
THR A  30
 None
 1.14A 4pgfA-5fhxA:
undetectable		 4pgfA-5fhxA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TRP H  33
HIS H  35
PHE H 110
GLN L 207
GLN L 208
 PO4  H 401 (-4.7A)
None
None
None
None
 0.78A 4uilH-5fhxH:
21.5
4uilL-5fhxH:
11.6		 4uilH-5fhxH:
44.93
4uilL-5fhxH:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5fhx ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 GLY L 219
PRO L 126
ALA L 127
ILE L 137
LEU L 222
 None
 1.17A 5bw4B-5fhxL:
undetectable		 5bw4B-5fhxL:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5fhx INTERLEUKIN-4
(Homo
sapiens) 		5 / 12 LEU A  14
PHE A 112
THR A  44
ALA A  48
LEU A  52
 None
 1.07A 5iepA-5fhxA:
undetectable		 5iepA-5fhxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens) 		5 / 10 ALA H 215
LEU H 142
LEU H 209
LEU H 172
LEU H 204
 None
 0.91A 6f5uA-5fhxH:
undetectable
6f5uB-5fhxH:
undetectable		 6f5uA-5fhxH:
11.92
6f5uB-5fhxH:
13.33