SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 7 LEU A 187
ILE A 357
THR A 209
GLN A 312
 None
 1.29A 1kglA-5fhzA:
undetectable		 1kglA-5fhzA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 ASP A 403
SER A 371
LEU A 368
PRO A 418
ILE A 407
 None
 1.24A 1ynnC-5fhzA:
0.9		 1ynnC-5fhzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 GLY A 282
LEU A 439
GLY A 486
ASN A 485
ALA A 254
 NAD  A 601 (-3.7A)
None
None
None
None
 0.99A 2bm9F-5fhzA:
3.1		 2bm9F-5fhzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 6 TYR A 492
PHE A 144
TYR A 143
LEU A 494
 None
 1.23A 2w98A-5fhzA:
undetectable
2w98B-5fhzA:
undetectable		 2w98A-5fhzA:
21.36
2w98B-5fhzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 9 ALA A  78
VAL A 230
GLY A 175
ILE A 232
ALA A  74
 None
 0.96A 2z0yB-5fhzA:
3.4		 2z0yB-5fhzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 7 ASN A 199
TYR A 497
ARG A  96
ALA A 192
 None
 1.41A 3frqB-5fhzA:
undetectable		 3frqB-5fhzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 10 VAL A 107
GLN A 102
LEU A 191
VAL A 188
LEU A 216
 None
 1.06A 3gwxA-5fhzA:
undetectable		 3gwxA-5fhzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 4 ILE A 419
GLN A 417
VAL A 320
PHE A 330
 None
 1.13A 3ieoA-5fhzA:
undetectable		 3ieoA-5fhzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 5 ASN A 273
GLU A 488
THR A 256
SER A 272
 None
 1.36A 3p2kC-5fhzA:
4.6		 3p2kC-5fhzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 GLY A 123
ASP A 358
ILE A 357
GLY A 354
PHE A 392
 None
 1.17A 3ps9A-5fhzA:
undetectable		 3ps9A-5fhzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 8 PHE A 144
HIS A 101
GLY A 146
GLY A 136
 None
None
None
REA  A 602 (-3.4A)
 0.73A 3v3nB-5fhzA:
1.5		 3v3nB-5fhzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 8 PHE A 144
HIS A 101
GLY A 146
GLY A 136
 None
None
None
REA  A 602 (-3.4A)
 0.74A 3v3nC-5fhzA:
1.4		 3v3nC-5fhzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 7 PRO A 415
ILE A 393
GLN A 356
GLY A 354
VAL A 343
 None
 1.38A 4a3uB-5fhzA:
undetectable		 4a3uB-5fhzA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.14A 4b7nA-5fhzA:
undetectable		 4b7nA-5fhzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.25A 4cpzC-5fhzA:
undetectable		 4cpzC-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.14A 4cpzE-5fhzA:
undetectable		 4cpzE-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.20A 4cpzF-5fhzA:
undetectable		 4cpzF-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.15A 4cpzG-5fhzA:
undetectable		 4cpzG-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 ARG A  96
ARG A  89
TRP A  88
 None
 1.25A 4cpzH-5fhzA:
undetectable		 4cpzH-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 11 GLY A 390
PRO A 415
ILE A 365
LEU A 366
ILE A 393
 None
 1.08A 4dt8A-5fhzA:
undetectable		 4dt8A-5fhzA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 10 GLY A 390
PRO A 415
ILE A 365
LEU A 366
ILE A 393
 None
 1.11A 4dt8B-5fhzA:
undetectable		 4dt8B-5fhzA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 PHE A 126
ASP A 348
ARG A  25
 None
 0.79A 4eahF-5fhzA:
undetectable		 4eahF-5fhzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 PHE A 126
ASP A 348
ARG A  25
 None
 0.79A 4eahG-5fhzA:
undetectable		 4eahG-5fhzA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 11 ASN A 181
LEU A 185
MET A 186
TRP A 189
PHE A 477
 REA  A 602 (-3.9A)
None
REA  A 602 (-4.4A)
REA  A 602 ( 4.5A)
None
 1.41A 4fr8A-5fhzA:
62.7		 4fr8A-5fhzA:
63.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		6 / 11 ASN A 181
PHE A 182
LEU A 185
MET A 186
TRP A 189
CYH A 314
 REA  A 602 (-3.9A)
REA  A 602 (-4.0A)
None
REA  A 602 (-4.4A)
REA  A 602 ( 4.5A)
REA  A 602 (-2.8A)
 0.82A 4fr8A-5fhzA:
62.7		 4fr8A-5fhzA:
63.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 ASP A 403
SER A 371
LEU A 368
PRO A 418
ILE A 407
 None
 1.29A 4kmuC-5fhzA:
undetectable		 4kmuC-5fhzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 GLY A 354
PRO A 355
GLN A 312
 None
 0.37A 4oltB-5fhzA:
undetectable		 4oltB-5fhzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		3 / 3 GLY A 354
PRO A 355
GLN A 312
 None
 0.27A 4qwpB-5fhzA:
undetectable		 4qwpB-5fhzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 ASP A 345
SER A  55
ASN A  53
ASP A 348
GLU A  58
 None
 1.13A 5iqeC-5fhzA:
undetectable		 5iqeC-5fhzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 8 ALA A 115
THR A 119
THR A 122
TRP A 180
 None
None
None
NAD  A 601 (-4.4A)
 0.81A 5x2tI-5fhzA:
undetectable
5x2tJ-5fhzA:
undetectable
5x2tK-5fhzA:
undetectable
5x2tL-5fhzA:
undetectable		 5x2tI-5fhzA:
13.72
5x2tJ-5fhzA:
13.91
5x2tK-5fhzA:
13.72
5x2tL-5fhzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 10 ILE A 232
ASN A 199
LEU A 187
ALA A 194
LEU A 195
 None
 1.18A 5y7pG-5fhzA:
undetectable		 5y7pG-5fhzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 10 ILE A 232
ILE A 138
ALA A 104
LEU A 103
ALA A 223
 None
 1.36A 5zjiB-5fhzA:
undetectable		 5zjiB-5fhzA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 12 SER A 399
LYS A 378
VAL A 331
CYH A 381
VAL A 335
 None
 1.39A 6bxlB-5fhzA:
2.9		 6bxlB-5fhzA:
23.74