SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 9 ILE A 324
ILE A 349
ASP A 348
GLY A  52
THR A 352
 None
 1.36A 2dtjA-5fi5A:
undetectable
2dtjB-5fi5A:
undetectable		 2dtjA-5fi5A:
17.39
2dtjB-5fi5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		4 / 7 TYR A  72
TYR A  56
CYH A 162
GLU A  77
 None
None
ZN  A 402 (-2.2A)
ZN  A 402 (-3.0A)
 1.40A 2xytD-5fi5A:
undetectable		 2xytD-5fi5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 11 VAL A 206
SER A 227
LEU A 244
ILE A 247
ALA A 167
 None
 1.18A 2zbzA-5fi5A:
undetectable		 2zbzA-5fi5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		6 / 12 LEU A 160
GLU A  77
GLY A  52
ILE A 349
ASP A 348
ALA A 133
 None
ZN  A 402 (-3.0A)
None
None
None
None
 1.46A 3gryA-5fi5A:
5.0		 3gryA-5fi5A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 9 GLY A 192
ILE A 251
GLY A 184
ILE A 183
LEU A 273
 None
 0.94A 3ogpA-5fi5A:
undetectable		 3ogpA-5fi5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 9 GLY A 192
ILE A 251
GLY A 184
ILE A 183
LEU A 273
 None
 0.95A 3ogpB-5fi5A:
undetectable		 3ogpB-5fi5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 GLY A 192
ILE A 251
GLY A 184
ILE A 183
LEU A 273
 None
 0.92A 3ogqB-5fi5A:
undetectable		 3ogqB-5fi5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		4 / 5 LEU A 154
GLY A  80
ILE A 146
VAL A 145
 None
 0.89A 3wriA-5fi5A:
undetectable		 3wriA-5fi5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		4 / 5 LEU A 154
GLY A  80
ILE A 146
VAL A 145
 None
 0.88A 3wriB-5fi5A:
undetectable		 3wriB-5fi5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 10 ILE A 349
LEU A 353
GLY A  52
ASP A  57
GLY A  75
 None
 1.18A 4bwlC-5fi5A:
undetectable		 4bwlC-5fi5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 10 ALA A 195
ILE A 185
ILE A 209
LEU A 260
ILE A 247
 None
 1.27A 4dtaA-5fi5A:
undetectable		 4dtaA-5fi5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 ALA A 167
GLY A 190
GLY A 192
LEU A 188
GLU A 322
 None
 1.07A 4lg1A-5fi5A:
undetectable		 4lg1A-5fi5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 ALA A 167
GLY A 190
GLY A 192
LEU A 188
GLU A 322
 None
 1.07A 4lg1B-5fi5A:
5.1		 4lg1B-5fi5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		4 / 6 ALA A 138
ILE A 347
GLY A  75
VAL A 158
 None
 0.78A 4r21A-5fi5A:
undetectable		 4r21A-5fi5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 11 GLY A 350
LEU A 353
LEU A  46
ALA A 138
SER A 135
 None
 1.13A 4wnuA-5fi5A:
undetectable		 4wnuA-5fi5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		3 / 3 GLY A 108
CYH A 113
CYH A 110
 ZN  A 401 ( 4.8A)
ZN  A 401 (-2.3A)
ZN  A 401 (-2.3A)
 0.94A 5inzB-5fi5A:
undetectable		 5inzB-5fi5A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 11 ILE A 326
ILE A 349
VAL A 329
GLU A  77
ALA A 133
 None
None
None
ZN  A 402 (-3.0A)
None
 1.01A 5lg3A-5fi5A:
undetectable		 5lg3A-5fi5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 ILE A 326
ILE A 349
VAL A 329
GLU A  77
ALA A 133
 None
None
None
ZN  A 402 (-3.0A)
None
 1.00A 5lg3E-5fi5A:
undetectable		 5lg3E-5fi5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 ARG A 182
PHE A 202
ILE A 248
ALA A 195
ALA A 225
 None
 1.13A 5veuA-5fi5A:
undetectable		 5veuA-5fi5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 THR A 250
ASP A 249
SER A 210
SER A 211
SER A 231
 None
None
PO4  A 403 (-2.7A)
PO4  A 403 ( 4.2A)
None
 1.39A 6h7jA-5fi5A:
undetectable		 6h7jA-5fi5A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		5 / 12 THR A 250
ASP A 249
SER A 210
SER A 211
SER A 231
 None
None
PO4  A 403 (-2.7A)
PO4  A 403 ( 4.2A)
None
 1.39A 6h7jB-5fi5A:
undetectable		 6h7jB-5fi5A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5fi5 TETRAHYDROALSTONINE
SYNTHASE
(Catharanthus
roseus) 		3 / 3 ASP A 249
SER A 211
SER A 231
 None
PO4  A 403 ( 4.2A)
None
 0.80A 6mxtA-5fi5A:
undetectable		 6mxtA-5fi5A:
21.50