SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 5fie CELL SURFACE PROTEIN
SPAA
(Lactobacillus
rhamnosus) 		5 / 9 PRO A 170
GLY A  49
PHE A  78
THR A  46
GLY A 113
 None
 1.32A 1h4oC-5fieA:
undetectable
1h4oD-5fieA:
undetectable		 1h4oC-5fieA:
22.22
1h4oD-5fieA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 5fie CELL SURFACE PROTEIN
SPAA
(Lactobacillus
rhamnosus) 		5 / 9 PRO A 170
GLY A  49
PHE A  78
THR A  46
GLY A 113
 None
 1.33A 1h4oE-5fieA:
undetectable
1h4oF-5fieA:
undetectable		 1h4oE-5fieA:
22.22
1h4oF-5fieA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5fie CELL SURFACE PROTEIN
SPAA
(Lactobacillus
rhamnosus) 		4 / 6 GLY A  67
PRO A  72
LYS A  47
THR A  46
 None
 1.15A 2m2oB-5fieA:
undetectable		 2m2oB-5fieA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5fie CELL SURFACE PROTEIN
SPAA
(Lactobacillus
rhamnosus) 		5 / 11 GLY A  69
ALA A  70
ASP A  51
ILE A  57
THR A  46
 None
 0.96A 4l1aA-5fieA:
undetectable		 4l1aA-5fieA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5fie CELL SURFACE PROTEIN
SPAA
(Lactobacillus
rhamnosus) 		4 / 6 THR A 108
LEU A 115
THR A 140
LEU A  73
 None
 1.21A 6mvxA-5fieA:
undetectable
6mvxB-5fieA:
undetectable
6mvxC-5fieA:
undetectable		 6mvxA-5fieA:
18.47
6mvxB-5fieA:
18.47
6mvxC-5fieA:
18.47