SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 11 PHE A 414
LEU A 403
GLY A 426
THR A 382
VAL A 380
None
1.28A 1akdA-5fifA:
undetectable
1akdA-5fifA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
3 / 3 SER A  85
GLU A  86
GLU A  87
None
0.71A 1eqbD-5fifA:
undetectable
1eqbD-5fifA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
3 / 3 SER A  85
GLU A  86
GLU A  87
None
0.70A 1eqbB-5fifA:
undetectable
1eqbB-5fifA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 ARG A  48
THR A 124
VAL A 125
ALA A 120
None
0.99A 1fo4B-5fifA:
undetectable
1fo4B-5fifA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 10 THR A 371
ASP A 255
LEU A 320
THR A 330
ILE A 343
None
1.43A 1i18A-5fifA:
undetectable
1i18B-5fifA:
undetectable
1i18A-5fifA:
11.03
1i18B-5fifA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.83A 1p7lD-5fifA:
undetectable
1p7lD-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.83A 1p7lC-5fifA:
undetectable
1p7lC-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 CYH A 369
PHE A 414
PHE A 365
LEU A 328
None
1.08A 1qcaA-5fifA:
undetectable
1qcaA-5fifA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 160
GLY A 159
GLY A 158
LEU A 206
ASN A 134
None
1.08A 1qzzA-5fifA:
undetectable
1qzzA-5fifA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 LEU A 141
LEU A 154
ALA A 204
ALA A 201
LEU A  98
None
1.36A 1rbpA-5fifA:
undetectable
1rbpA-5fifA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.82A 1rg9B-5fifA:
undetectable
1rg9B-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.84A 1rg9A-5fifA:
undetectable
1rg9A-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.83A 1rg9D-5fifA:
undetectable
1rg9D-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.82A 1rg9C-5fifA:
undetectable
1rg9C-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 160
GLY A 159
GLY A 158
LEU A 206
ASN A 134
None
1.06A 1xdsA-5fifA:
undetectable
1xdsA-5fifA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 160
GLY A 159
GLY A 158
LEU A 206
ASN A 134
None
1.07A 1xdsB-5fifA:
undetectable
1xdsB-5fifA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 LEU A  92
GLY A  97
ASP A  96
ALA A  95
ALA A  74
None
1.24A 2br4B-5fifA:
undetectable
2br4B-5fifA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 9 LEU A 514
ARG A 511
LEU A 377
LEU A 379
ALA A 312
None
1.33A 2bxeA-5fifA:
undetectable
2bxeA-5fifA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 11 LEU A 318
LEU A 332
LEU A 374
ARG A 270
THR A 371
None
1.18A 2qd3A-5fifA:
undetectable
2qd3A-5fifA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 PRO A 445
VAL A 504
SER A 443
GLU A 491
None
1.06A 2v2gA-5fifA:
undetectable
2v2gB-5fifA:
undetectable
2v2gA-5fifA:
16.78
2v2gB-5fifA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 PRO A 445
VAL A 504
SER A 443
GLU A 491
None
1.05A 2v2gC-5fifA:
undetectable
2v2gD-5fifA:
undetectable
2v2gC-5fifA:
16.78
2v2gD-5fifA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 PRO A 445
VAL A 504
SER A 443
GLU A 491
None
1.06A 2v41E-5fifA:
undetectable
2v41F-5fifA:
undetectable
2v41E-5fifA:
16.78
2v41F-5fifA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 PRO A 445
VAL A 504
SER A 443
GLU A 491
None
0.98A 2v41G-5fifA:
undetectable
2v41H-5fifA:
undetectable
2v41G-5fifA:
16.78
2v41H-5fifA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 158
GLY A 197
ALA A 201
GLY A 202
LEU A 207
None
0.98A 3ku1A-5fifA:
2.4
3ku1A-5fifA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 158
ALA A 201
GLY A 202
LEU A 207
ILE A 221
None
1.03A 3ku1G-5fifA:
undetectable
3ku1G-5fifA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ASP A 211
LEU A 332
LEU A 368
CYH A 369
None
1.01A 3lm8A-5fifA:
undetectable
3lm8C-5fifA:
undetectable
3lm8A-5fifA:
16.17
3lm8C-5fifA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 193
ALA A 156
ILE A 214
ALA A 268
VAL A 153
None
1.07A 3nvkI-5fifA:
undetectable
3nvkI-5fifA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 327
GLY A 358
ILE A 354
ASP A 381
VAL A 349
None
1.11A 3o7wA-5fifA:
undetectable
3o7wA-5fifA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 GLY A 424
GLY A 384
GLU A 448
GLN A 489
ALA A 486
EDO  A 601 ( 3.2A)
EDO  A 601 ( 2.8A)
None
None
None
1.23A 3t7vA-5fifA:
undetectable
3t7vA-5fifA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 5 LEU A 377
ALA A 416
PHE A 414
ASN A 345
None
1.45A 3uq6A-5fifA:
3.0
3uq6A-5fifA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 4 LEU A 377
ALA A 416
PHE A 414
ASN A 345
None
1.49A 3vaqA-5fifA:
4.9
3vaqA-5fifA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 4 LEU A 377
ALA A 416
PHE A 414
ASN A 345
None
1.49A 3vasA-5fifA:
3.7
3vasA-5fifA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 6 SER A 378
THR A 330
ILE A 343
THR A 419
None
1.06A 4acbC-5fifA:
2.2
4acbC-5fifA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 7 GLN A 287
ASN A 512
TRP A 513
ILE A 505
None
1.03A 4ii8A-5fifA:
undetectable
4ii8A-5fifA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.87A 4ndnD-5fifA:
undetectable
4ndnD-5fifA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 PHE A 414
ALA A 408
LEU A 410
PHE A 324
None
0.98A 4rkuA-5fifA:
undetectable
4rkuJ-5fifA:
undetectable
4rkuA-5fifA:
22.45
4rkuJ-5fifA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 4 GLY A 426
LEU A 366
PHE A 365
ILE A 343
None
0.81A 4xv2A-5fifA:
undetectable
4xv2A-5fifA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
3 / 5 GLY A 187
GLY A 530
GLU A 529
None
0.39A 4z2eA-5fifA:
undetectable
4z2eD-5fifA:
undetectable
4z2eA-5fifA:
22.08
4z2eD-5fifA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
3 / 3 ALA A 268
TYR A 271
PRO A 151
None
0.52A 4zdyA-5fifA:
undetectable
4zdyA-5fifA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 VAL A 102
LEU A 191
GLY A 146
ALA A 145
LEU A 141
None
1.35A 5iktB-5fifA:
undetectable
5iktB-5fifA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 10 LEU A 185
PHE A 182
PRO A 151
ALA A 117
PRO A 535
None
1.39A 5m0oA-5fifA:
undetectable
5m0oA-5fifA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
4 / 8 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.84A 5t8sA-5fifA:
undetectable
5t8sA-5fifA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 ALA A 422
ARG A 420
PHE A 449
GLY A 447
ILE A 505
None
1.17A 5ul4A-5fifA:
2.5
5ul4A-5fifA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
3 / 3 TYR A 271
ASP A 255
ASP A 211
None
0.68A 5x6yA-5fifA:
2.3
5x6yA-5fifA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
5fif CARBOXYLASE
(Deinococcus
radiodurans)
5 / 12 TRP A 444
VAL A 380
THR A 382
VAL A 304
TYR A 302
None
1.38A 6drxA-5fifA:
undetectable
6drxA-5fifA:
21.39