SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.11A 2aylA-5fiiA:
undetectable		 2aylA-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		4 / 4 LEU A  91
THR A  92
ILE A  38
HIS A 107
 None
 1.05A 2jfaB-5fiiA:
undetectable		 2jfaB-5fiiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 ILE A  94
LEU A  41
PHE A  55
ILE A  65
LEU A  62
 None
None
None
PHE  A 901 ( 4.3A)
PHE  A 901 (-3.6A)
 1.11A 2w3bA-5fiiA:
undetectable		 2w3bA-5fiiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 ILE A  94
LEU A  41
PHE A  55
ILE A  65
LEU A  62
 None
None
None
PHE  A 901 ( 4.3A)
PHE  A 901 (-3.6A)
 1.10A 2w3bB-5fiiA:
undetectable		 2w3bB-5fiiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 ILE A  94
LEU A  41
PHE A  55
ILE A  65
LEU A  62
 None
None
None
PHE  A 901 ( 4.3A)
PHE  A 901 (-3.6A)
 1.09A 2w3mA-5fiiA:
undetectable		 2w3mA-5fiiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.10A 3pghD-5fiiA:
undetectable		 3pghD-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.06A 4coxC-5fiiA:
undetectable		 4coxC-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 ILE A  94
LEU A  41
PHE A  55
ILE A  65
LEU A  62
 None
None
None
PHE  A 901 ( 4.3A)
PHE  A 901 (-3.6A)
 1.10A 4kebB-5fiiA:
undetectable		 4kebB-5fiiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.09A 4otyA-5fiiA:
undetectable		 4otyA-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.07A 4otyB-5fiiA:
undetectable		 4otyB-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.05A 4rrwD-5fiiA:
undetectable		 4rrwD-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.05A 4rrzD-5fiiA:
undetectable		 4rrzD-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 9 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.05A 4rs0A-5fiiA:
undetectable		 4rs0A-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.12A 5ikqA-5fiiA:
undetectable		 5ikqA-5fiiA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.12A 5ikqB-5fiiA:
undetectable		 5ikqB-5fiiA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.17A 5ikrA-5fiiA:
undetectable		 5ikrA-5fiiA:
12.69